Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes
https://doi.org/10.58838/2075-1230-2024-102-4-84-92
Abstract
The objective: to evaluate state of extracellular matrix markers and their tissue inhibitors during development and formation of clinical phenotypes of COPD, in patients facing the high risk of developing exacerbations.
Subjects and Methods. 96 COPD patients (73% men and 27% women) were examined. Patients were randomized into the following groups: Group 1 included 40 COPD patients with bronchitis phenotype; Group 2 included 38 patients with emphysema phenotype; and Control Group consisted of 18 practically healthy subjects. All patients underwent a comprehensive clinical and laboratory examination. Levels of matrix metalloproteinases (total MMP-9 and MMP-2) and their tissue inhibitors TIMMP1 and TIMMP2 were determined by ELISA.
Results. The development of COPD, regardless of the clinical phenotype of the disease, is accompanied by pronounced expression of extracellular matrix markers MMP-9 and MMP-2. Regardless of the COPD clinical phenotype, elevated activity of metalloproteinases is accompanied by inhibition of production of TIMMP2 and dysfunction of the MMP-9/TIMMP1 antiprotease system. In COPD patients with MMP-2 level of 214 ng/ml, the formation of bronchitis phenotype can be predicted, while with MMP-2 level of 214 ng/ml or more, the formation of emphysema phenotype can be predicted.
About the Authors
T. V. Tayutina
Rostov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Tatiana V. Tayutina, Candidate of Medical Sciences, Associate Professor, Head of Polyclinic and Emergency Therapy Department
29 Nakhichevansky Lane, Rostov-on-Don, 344022
Phone: +7 (863) 250-41-16
S. V. Shlyk
Rostov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Sergey V. Shlyk, Doctor of Medical Sciences, Provost, Professor, Head of Department of Medical Law, Public Health and Healthcare
29 Nakhichevansky Lane, Rostov-on-Don, 344022
Phone: +7 (863) 250-41-16
D. A. Kudlay
I.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of Health; Lomonosov Moscow State University; Immunology Research Institute by Federal Medical Biological Agency
Russian Federation
Russian Federation
Dmitry A. Kudlay, Correspondent Member of RAS, Doctor of Medical Sciences, Professor of Pharmacology Department of Pharmacy Institute, Leading Researcher of Laboratory of Personalized Medicine and Molecular Immunology no. 71., Professor of Department of Pharmacognosy and Industrial Pharmacy, Faculty of Fundamental Medicine
8 Bd. 2, Trubetskaya St., Moscow, 119991
Phone: +7 (499) 248-05-53
S. V. Smerdin
Moscow Regional Clinical TB Dispensary; M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
Russian Federation
Sergey V. Smerdin, Doctor of Medical Sciences, Professor, Head Physician, Head of Phthisiology Department
11 Bd. 1 Borby Sq., Moscow, 127030
Phone: +7(496) 588-41-29
L. A. Shovkun
Rostov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Lyudmila A. Shovkun, Doctor of Medical Sciences, Professor, Head of Tuberculosis Department
29 Nakhichevansky Lane, Rostov-on-Don, 344022
Phone: +7 (863) 250-41-16
E. A. Kizhevatova
Rostov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Elena A. Kizhevatova, Senior Lecturer at Department of Medical Physics, Mathematics and Information Technologies
29 Nakhichevansky Lane, Rostov-on-Don, 344022
Phone: +7 (863) 250-41-16
N. Yu. Nikolenko
Moscow Research and Clinical Center for Tuberculosis Control, Moscow Government Department of Health
Russian Federation
Russian Federation
Nikolay Yu. Nikolenko, Candidate of Pharmacological Sciences, Researcher of Research Clinical Department
10 Stromynka St., Moscow, 107014
Phone: + 7 (499) 268-00-05
E. D. Kampos
Rostov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Elena D. Kampos, Candidate of Medical Sciences, Associate Professor of Tuberculosis Department
29 Nakhichevansky Lane, Rostov-on-Don, 344022
Phone: +7 (863) 250-41-16
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Review
For citations:
Tayutina T.V., Shlyk S.V., Kudlay D.A., Smerdin S.V., Shovkun L.A., Kizhevatova E.A., Nikolenko N.Yu., Kampos E.D. Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes. Tuberculosis and Lung Diseases. 2024;102(4):84-92. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-4-84-92
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