Prevalence of Latent Tuberculosis Infection among Residents of Social Housing
https://doi.org/10.58838/2075-1230-2024-102-5-6-11
Abstract
The objective: to assess the prevalence of latent tuberculosis infection among people living in social housing.
Subjects and Methods. Prevalence of latent tuberculosis infection (LTBI) was analyzed among residents of two social homes in Moscow; totally 936 people were examined. These individuals were given a skin test with the tuberculous recombinant allergen (TRA). To exclude tuberculosis, those with a positive response underwent examination and tests including chest computed tomography and 3 consecutive sputum smears for acid-fast mycobacteria. If tuberculosis was ruled out according to the results, the condition of these individuals was classified as latent tuberculosis infection (LTBI).
Results. Among those living in social housing, LTBI was more common in men than in women, OR=1.72 (95% CI 1.16–2.57). In persons with mental retardation, LTBI was detected more often than in those with schizophrenia: 20.68% versus 12.44%, p<0.05. The presence of concomitant diseases (diabetes mellitus, COPD, viral hepatitis, gastrointestinal pathology, oncology, and autoimmune diseases) is no risk factor for LTBI in people with mental pathology.
About the Authors
E. T. Khalafova
Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health
Russian Federation
Russian Federation
Elvira T. Khalafova, Acting Deputy Head for Medical Activities of the Branch of Eastern and North-Eastern Administrative Districts
10 Stromynka St., Moscow, 107014 Phone: + 7 (499) 268-00-05
E. M. Bogorodskaya
Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health ; Russian Medical Academy of On-going Professional Education, Russian Ministry of Health
Russian Federation
Russian Federation
Elena M. Bogorodskaya, Doctor of Medical Sciences, Professor, Director, Head of Phthisiology Department
10 Stromynka St., Moscow, 107014 Phone: + 7 (499) 268-00-05
2/1 Build. 1 Barrikadnaya St., Moscow, 125993
References
1. Bogorodskaya E.M., Slogotskaya L.V., Tuktarova L.M., Oganezova G.S., Musatkina N.V., Litvinova N.V. Screening for tuberculosis infection in risk groups in the adult population of Moscow. Tuberculosis and Lung Diseases, 2023, vol. 101, no. 4, pp. 13-21. (In Russ.) https://doi.org/10.58838/2075-1230-2023-101-4-13-21
2. Morozova T.I. Latent for tuberculosis infection in risk groups in adult population Saratov Region. Meditsinsky Soviet, 2023, vol. 17, no. 4, pp. 92-100. (In Russ.) https://doi.org/10.21518/ms2023-054
3. Edict no. 308 by Moscow Health Department dated April 17, 2015 On Use of Skin Test with Tuberculous Recombinant Allergen in Standard Dilution in Public Medical Units of the City of Moscow when Examining Risk Groups for Tuberculosis. (In Russ.) Available: https://garant.ru Accessed September 15, 2024
4. Aghanwa H.S., Gregory E. Erhabor, Demographic/socioeconomic factors in mental disorders associated with tuberculosis in southwest Nigeria. Journal of Psychosomatic Research, 1998, vol. 45, no. 4, pp. 353-360. https://doi.org/10.1016/S0022-3999(98)00006-3
5. Dorken E., Grzybowski S., Edward A.A. Significance of the tuberculin test in the elderly. Chest, 1987, vol. 92, no. 2, pp. 237-240. https://doi.org/10.1378/chest.92.2.2
6. Hayward S.E., Deal A., Rustage K. et al. The relationship between mental health and risk of active tuberculosis: a systematic review-2021. MJ Open, 2022, vol. 12, no. 1, pp. e048945. https://doi.org/10.1136/bmjopen-2021-048945
7. Herbert T.B., Cohen S. Depression and immunity: a meta-analytic review. Psychological Bulletin, 1993, vol. 113, no. 3, pp. 472-486. https://doi.org/10.1037/0033-2909.113.3.472
8. Johnston R.N., Ritchie R.T., Murray I.H. Declining tuberculin sensitivity with advancing age. Br. Med J., 1963, vol. 2, no. 5359, pp. 720–724. https://doi.org/10.1136/bmj.2.5359.720
9. Kuo S.C., Chen Y.T., Li S.Y., Lee Y.T., Yang A.C., Chen T.L. et al. Incidence and outcome of newly-diagnosed tuberculosis in schizophrenics: a 12-year, nationwide, retrospective longitudinal study. BMC Infect Dis., 2013, no. 13, pp. 351. https://doi.org/10.1186/1471-2334-13-351
10. Meng-Rui Lee, Ya-Ping Huang, Yu-Ting Kuo, Chen-Hao Luo, Yun-Ju Shih, Chin-Chung Shu et al. Diabetes Mellitus and Latent Tuberculosis Infection: A Systemic Review and Metaanalysis. Clinical Infection Diseases, 2017, vol. 64, no. 6, pp. 719-727. https://doi.org/10.1093/cid/ciw836
11. Sikjær M.G., Løkke A., Hilberg O. The influence of psychiatric disorders on the course of lung cancer, chronic obstructive pulmonary disease and tuberculosis. Respir Med., 2018, no. 135, pp. 35-41. https://doi.org/10.1016/j.rmed.2017.12.012
12. Steiner J., Jacobs R., Panteli B. et al. Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity. Eur. Arch. Psychiatry Clin. Neurosci., 2010, no. 260, pp. 509-518. https://doi.org/10.1007/s00406-010-0098-x
13. Theron G., Peter J., Zijenah L., Chanda D., Mangu C., Clowes P. et al. Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study. BMC Infect Dis., 2015, no. 15, pp. 253. https://doi.org/10.1186/s12879-015-0964-2
Review
For citations:
Khalafova E.T., Bogorodskaya E.M. Prevalence of Latent Tuberculosis Infection among Residents of Social Housing. Tuberculosis and Lung Diseases. 2024;102(5):6-11. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-5-6-11
Views:
425
Email this article 