Detection of Non-Tuberculous Mycobacteria and Treatment of Mycobacteriosis in Arkhangelsk Oblast in 2010–2020
https://doi.org/10.58838/2075-1230-2024-102-5-12-20
Abstract
The objective: to assess detection rates of non-tuberculous mycobacteria (NTM), incidence of mycobacteriosis, and results of mycobacteriosis treatment in Arkhangelsk Oblast from 2010 to 2020.
Subjects and Methods. All patients in whom mycobacteria were detected by microscopy and/or culture with a negative result for M. tuberculosis were examined for NTM. Patients with NTM who had two positive cultures and/or clinical findings suggestive of the disease received treatment of mycobacteriosis.
Results. In Arkhangelsk Oblast from 2010 to 2020, NTM were detected in 138 people, with an average rate of 1.09 cases per 100,000 population. Mycobacteria belonging to the M. avium complex (M. avium and M. intralcelulare) (MAC) were reported in the majority of cases (56/138; 40%). In 19/138 (14%) patients, the type of NTM could not be determined. The diagnosis of mycobacteriosis was registered in 67/138 (49%) people, with an average rate of 0.53 cases per 100,000 population. In 45/67 (67%) cases, the disease was caused by MAC. In 71/138 (51%) patients with NTM, no mycobacteriosis was diagnosed. Treatment was started in 60/67 (90%) patients with mycobacteriosis, and in 58/60 (97%) the regimen contained clarithromycin. Results were as follows: treatment was completed in 37 (62%) patients, 10 (16%) patients were defaulters, treatment was canceled for medical reasons in 5 (8%) cases, 1 (2%) patient died of mycobacteriosis, 4 (7%) patients died of other causes, 2 (3%) patients were transferred out, and treatment failed in 1 (2%) patient.
About the Authors
P. I. Eliseev
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health ; Northern State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Platon I. Eliseev, Candidate of Medical Sciences, Associate Professor of Phthisiopulmonology Department, Leading Researcher of Laboratory of Microbiology, Virology and Molecular Biological Research Methods
51 Troitsky Ave., Arkhangelsk, 163069 Phone: + 7 (8182) 66-05-64
T. I. Gurieva
Northern State Medical University, Russian Ministry of Health ; Arkhangelsk Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Tatiana I. Gurieva, Assistant of Phthisiopulmonology Department, Phthisiologist
51 Troitsky Ave., Arkhangelsk, 163069 Phone: + 7 (8182) 66-05-64
E. I. Nikishova
Northern State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Elena I. Nikishova, Doctor of Medical Sciences, Professor of Phthisiopulmonology Department
51 Troitsky Ave., Arkhangelsk, 163069 Phone: + 7 (8182) 66-05-64
E. S. Khimova
Northern State Medical University, Russian Ministry of Health ; Arkhangelsk Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Elena S. Khimova, Assistant of Phthisiopulmonology Department, Phthisiologist
51 Troitsky Ave., Arkhangelsk, 163069 Phone: + 7 (8182) 66-05-64
A. O. Maryandyshev
Northern State Medical University, Russian Ministry of Health ; Northern (Arctic) Federal University Named after M.V. Lomonosov
Russian Federation
Russian Federation
Andrey O. Maryandyshev, Correspondent Member of RAS, Doctor of Medical Sciences, Professor, Head of Phthisiopulmonology Department, Leading Researcher of Research Department
51 Troitsky Ave., Arkhangelsk, 163069 Phone: + 7 (8182) 66-05-64
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Review
For citations:
Eliseev P.I., Gurieva T.I., Nikishova E.I., Khimova E.S., Maryandyshev A.O. Detection of Non-Tuberculous Mycobacteria and Treatment of Mycobacteriosis in Arkhangelsk Oblast in 2010–2020. Tuberculosis and Lung Diseases. 2024;102(5):12-20. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-5-12-20
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