Generalized Mycobacteriosis in HIV Patients
https://doi.org/10.58838/2075-1230-2024-102-5-50-57
Abstract
The objective: to evaluate clinical, laboratory and instrumental signs of generalized mycobacteriosis (MB) in HIV patients.
Subjects and Methods. Generalized MB was diagnosed in 83 patients with HIV, patients. 57.8% (48 people) were men, while 42.2% (35 people) were women. The average age of patients was 39.2 years (from 19 to 63 years).
Results. The M. avium complex was the main etiological agent of generalized MB in HIV patients (97.6%). The most frequent clinical manifestations included fever (80/83 (96.1%)); abdominal discomfort and pain, diarrhea (53/83 (63.8%)), and decreased body weight (56/83 (67%)). The median CD4+ count in the group was 50 cells/μL. In 52% (43/83) of cases, generalized MB developed concurrently with other opportunistic or secondary infections (CMVI, pneumocystis pneumonia, and candidiasis). In 70% of cases (55/78), NTMs were isolated from two or more biological specimens. The positive result of blood culture for NTM had the greatest clinical significance (in 32/60 (53%) of the examined patients).
About the Authors
E. I. Veselova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Elena I. Veselova, Candidate of Medical Sciences, Senior Researcher of Infectious Pathology Research Department
Build. 2, 4 Dostoevskiy St., Moscow, 127994 Phone: + 7 (495) 631-15-15
E. N. Kuznetsova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Elena N. Kuznetsova, Phthisiologist
Build. 2, 4 Dostoevskiy St., Moscow, 127994 Phone: + 7 (495) 631-15-15
A. B. Peregudova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Alla B. Peregudova, Candidate of Medical Sciences, Head of Infectious Department for HIV Treatment
Build. 2, 4 Dostoevskiy St., Moscow, 127994 Phone: + 7 (495) 631-15-15
V. V. Tinkova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Valentina V. Tinkova, Candidate of Medical Sciences, Deputy Head Physician for Medical Activities
Build. 2, 4 Dostoevskiy St., Moscow, 127994 Phone: + 7 (495) 631-15-15
A. A. Kazyulina
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Anastasia A. Kazyulina, Researcher, Acting Head of Scientific Laboratory of Microbiology, Virology and Molecular Genetic Testing
Build. 2, 4 Dostoevskiy St., Moscow, 127994 Phone: + 7 (495) 631-15-15
I. A. Vasilyeva
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Irina A. Vasilyeva, Doctor of Medical Sciences, Professor, Director
Build. 2, 4 Dostoevskiy St., Moscow, 127994 Phone: + 7 (495) 631-15-15
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Review
For citations:
Veselova E.I., Kuznetsova E.N., Peregudova A.B., Tinkova V.V., Kazyulina A.A., Vasilyeva I.A. Generalized Mycobacteriosis in HIV Patients. Tuberculosis and Lung Diseases. 2024;102(5):50-57. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-5-50-57
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