Insights into Population Genetics and Phylogeography of Mycobacterium tuberculosis
https://doi.org/10.58838/2075-1230-2024-102-5-91-98
Abstract
The review summarizes the current understanding of population genetics and genetic classification of Mycobacterium tuberculosis. Articles accumulated in Elibrary and PubMed were used as a source of information. Using keywords, more than 100 publications were found and analyzed for the period from 2009 to 2023, 35 of which were included in the review. According to the current concept, M. tuberculosis is represented by nine lineages (superfamilies L1-L9), each of which has different characteristics of evolutionary status, genetic diversity, transmissibility, drug resistance, latency, and vaccine effectiveness.
Keywords
Mycobacterium tuberculosis,
population genetics,
genetic lineages,
sublineages,
subclades,
phylogeography
Supporting agencies: This research was funded by Russian Science Foundation Grant No. 22-25-20209, https://rscf.ru/project/22-25-20209 and the Ministry of Science and Higher Education of Kuzbass.
About the Authors
B. A. Tkhorenko
Kemerovo State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Boris A. Tkhorenko, Engineer and Researcher of Molecular and Cellular Biology Department
22A Voroshilova St., Kemerovo, 650056 Phone: + 7 (3842) 52-10-18
A. V. Meyer
Kemerovo State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Alina V. Meyer, Associate Professor of Molecular and Cellular Biology Department
22A Voroshilova St., Kemerovo, 650056 Phone: + 7 (3842) 52-10-18
T. V. Pyanzova
Kemerovo State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Tatiana V. Pyanzova, Head of Phthisiology Department
22A Voroshilova St., Kemerovo, 650056 Phone: + 7 (3842) 52-10-18
A. V. Lyamin
Samara State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Artem V. Lyamin, Director of Scientific and Educational Professional Center for Genetic and Laboratory Technologies
89 Chapaevskaya St., Samara, 443099 Phone: + 7 (846) 374-91-00
M. B. Lavryashina
Kemerovo State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Mariya B. Lavryashina, Head of Molecular and Cellular Biology Department
22A Voroshilova St., Kemerovo, 650056 Phone: + 7 (3842) 52-10-18
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Tkhorenko B.A., Meyer A.V., Pyanzova T.V., Lyamin A.V., Lavryashina M.B. Insights into Population Genetics and Phylogeography of Mycobacterium tuberculosis. Tuberculosis and Lung Diseases. 2024;102(5):91-98. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-5-91-98
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