In vitro Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement
https://doi.org/10.58838/2075-1230-2024-102-6-66-72
Abstract
The objective: to assess elution characteristics of certain antiviral drugs immersed in bone cement samples and placed in a liquid medium to determine the fundamental possibility of using such systems.
Subjects and Methods. For the in vitro study, dispersed ART formulation mixed with bone cement were used. To study kinetics of drug elution, a spectrophotometry was used.
Results. It was found out that raltegravir, emtricitabine and lamivudine possessed satisfactory thermostability and elution parameters thus allowing their use in a mixture with bone cement. The results demonstrated the fundamental possibility of developing systems with controlled release of these drugs immersed in bone cement and placed into a liquid medium.
About the Authors
E. O. Peretsmanas
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Evgeniy O. Peretsmanas - Doctor of Medical Sciences, Head of Research Department of Osteoarticular Pathology
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
A. A. Artyukhov
Mendeleev University of Chemical Technology; A.N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences
Russian Federation
Russian Federation
Aleksandr A. Artyukhov - Doctor of Chemical Sciences, Professor of Biomaterials Department, Head of Laboratory of Biopolymer Cryochemistry, A.N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences
9 Miusskaya Sq., Moscow 125047
Phone: +7 (499) 978-85-20
I. A. Gerasimov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Ilya A. Gerasimov - Traumatologist and Orthopedist of Extrapulmonary Tuberculosis Department
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
V. S. Zubikov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Vladimir S. Zubikov - archer of Research Department of Osteoarticular Pathology
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
T. E. Tyulkova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Tatyana E. Tyulkova - Doctor of Medical Sciences, Chief Researcher
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
Ya. A. Rukin
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Yaroslav A. Rukin - Doctor of Medical Sciences, Leading Researcher of Research Department of Osteoarticular Pathology
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
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Review
For citations:
Peretsmanas E.O., Artyukhov A.A., Gerasimov I.A., Zubikov V.S., Tyulkova T.E., Rukin Ya.A. In vitro Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement. Tuberculosis and Lung Diseases. 2024;102(6):66-72. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-6-66-72
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