The Novel Coronavirus Infection of COVID-19 in HIV Positive Patients and Predictors of an Unfavorable Outcome in In-Patient Settings
https://doi.org/10.58838/2075-1230-2024-102-6-98-107
Abstract
The objective: to identify specific features of the COVID-19 course in HIV positive patients and risk factors for unfavourable outcomes in such patients.
Subjects and Methods. Patients with COVID-19 regardless of their HIV status admitted to hospital were enrolled in a retrospective observational study.
Results. HIV positive patients experienced a more severe course of COVID-19 including more extensive lung tissue damage and severe respiratory failure. Shortness of breath was more common of patients with HIV infection. Laboratory tests revealed adecreased antiviral immune response, signs of anemia and liver damage, and a tendency to develop blood clots. When developing a prognostic logistic regression model in patients with COVID-19 and HIV infection, it was revealed that the risk of an unfavorable outcome was associated with such factors as a decrease in the relative number of lymphocytes and level of total protein in peripheral blood at the moment of admission to hospital.
Conclusions. Given the elevated risk of a severe course and unfavorable outcome of COVID-19 in case of concurrent HIV infection, it is necessary to monitor symptoms of respiratory failure in these patients, and if they appear, make a decision about hospitalization at an earlier stage of the disease.
About the Authors
N. D. Urushadze
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Natalia D. Urushadze - Junior Researcher of Infectious Pathology Research Department
Phone: +7 (905) 704-71-30
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
N. Yu. Pshenichnaya
Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
Natalya Yu. Pshenichnaya - Doctor of Medical Sciences, Professor, Deputy Director for Clinical and Analytical Activities
Phone: +7 (495) 304-22-01, ext. 1205
3A Novogireevskaya St., Moscow 111123
L. E. Parolina
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Lyubov E. Parolina - Doctor of Medical Sciences, Professor, Head of Education Center
Phone: +7 (495) 631-15-15, ext. 5009
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
I. A. Lizinfeld
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Irina A. Lizinfeld - Candidate of Medical Sciences, Researcher of Infectious Pathology Research Department
Phone: +7 (495) 631-15-15, ext. 5011
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
I. A. Vasilyeva
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Irina A. Vasilyeva - Doctor of Medical Sciences, Professor, Director, Head of Phthisiology Department, Pirogov Russian National Research Medical University, Russian Ministry of Health
Phone: +7 (495) 631-15-15, ext. 1003
Build. 2, 4 Dostoevskiy St., Moscow, 127473
Phone: +7 (495) 681-11-66
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Review
For citations:
Urushadze N.D., Pshenichnaya N.Yu., Parolina L.E., Lizinfeld I.A., Vasilyeva I.A. The Novel Coronavirus Infection of COVID-19 in HIV Positive Patients and Predictors of an Unfavorable Outcome in In-Patient Settings. Tuberculosis and Lung Diseases. 2024;102(6):98-107. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-6-98-107
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