Preview

Tuberculosis and Lung Diseases

Advanced search

A Modern View of Cough Pathophysiology

https://doi.org/10.58838/2075-1230-2024-102-6-118-126

Abstract

Cough ensures cleansing of the upper respiratory tract from foreign particles, mucus, and microorganisms, so a health care professional specializing in any field needs to know the physiology of this unconditional reflex for a better understanding of its nature. 43 publications are presented in the review. It analyzes types, frequency, prevalence of chronic cough, afferent and efferent links of the cough reflex, central regulation, and involvement of inflammatory mediators.

About the Authors

A. V. Budnevskiy
Voronezh State Medical Academy Named after N.N. Burdenko, Russian Ministry of Health
Russian Federation

Andrey V. Budnevskiy - Doctor of Medical Sciences, Professor, Honored Innovator of Russia, Head of Faculty Therapy Department

10 Studencheskaya St., Voronezh 394036

Phone: + 7 (473) 263-81-30



S. N. Avdeev
I.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of Health
Russian Federation

Sergey N. Avdeev - Doctor of Medical Sciences, Academician of RAS, Professor, Head of Pulmonology Department, Institute of Clinical Medicine named after N.V. Sklifosovsky

8 Bd. 2, Trubetskaya St., Moscow, 119991

Phone: + 7 (495) 708-35-76



E. S. Ovsyannikov
Voronezh State Medical Academy Named after N.N. Burdenko, Russian Ministry of Health
Russian Federation

Evgeny S. Ovsyannikov - Doctor of Medical Sciences, Professor of Faculty Therapy Department

10 Studencheskaya St., Voronezh 394036

Phone: + 7 (473) 263-81-30



S. N. Feygelman
Voronezh State Medical Academy Named after N.N. Burdenko, Russian Ministry of Health
Russian Federation

Sophya N. Feygelman - Assistant of Faculty Therapy Department

10 Studencheskaya St., Voronezh 394036

Phone: + 7 (473) 263-81-30



References

1. Budnevskiy A.V., Avdeev S.N., Ovsyannikov E.S., Feygelman S.N., Choporov O.N., Maksimov A.V., Pertsev A.V. Spectral analysis of cough sounds of patients with COVID-19. Pulmonologiya, 2022, vol. 32, no. 6, pp. 834-841. (In Russ.) https://doi.org/10.18093/0869-0189-2022-32-6-834-841

2. Budnevskiy A.V., Ovsyannikov E.S., Feygelman S.N. The study of the efficacy of Levopront for the treatment of non-productive cough. Prakticheskaya Pulmonologiya, 2021, no. 2, pp. 65-74. (In Russ.) https://doi.org/10.24412/2409-6636-2021-12693

3. Bulgakova V.A., Ignatova A.S. Cough: from understanding the pathophysiology to the choice of therapy. Pediatriya. Journal im. G.N. Speranskogo, 2017, vol. 1, no. 96, pp. 142-150. (In Russ.)

4. Ovsyannikov E.S., Avdeev S.N., Budnevskiy A.V., Drobysheva E.S. Cough diagnosis: present and future. Tuberculosis and Lung Diseases, 2021, vol. 99, no. 11, pp. 56-65. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-11-56-64

5. Ovsyannikov E.S., Feygelman S.N., Alekseeva N.G. On the issue of cough treatment in COVID-19 patients. Terapiya, 2022, vol. 8, no. S4(56), pp. 99-102. (In Russ.) https://doi.org/10.18565/therapy.2022.4suppl.100-103

6. Abdulqawi R., Dockry R., Holt K., Layton G., McCarthy B.G., Ford A.P., Smith J.A. P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study. Lancet, 2015, vol. 9974, no. 385, pp. 1198-1205. https://doi.org/10.1016/S0140-6736(14)61255-1

7. Bessac B.F., Jordt S.E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda), 2008, no. 23, pp. 360-370. https://doi.org/10.1152/physiol.00026.2008

8. Bonvini S.J., Birrell M.A., Smith J.A., Belvisi M.G. Targeting TRP channels for chronic cough: from bench to bedside. Naunyn Schmiedebergs Arch. Pharmacol., 2015, no. 388, pp. 401-420.

9. Canning B.J., Chang A.B., Bolser D.C., Smith J.A., Mazzone S.B., McGarvey L. Anatomy and neuro- physiology of cough: CHEST Guideline and EXpert Panel report. Chest, 2014, no. 146, pp. 1633-1648. https://doi.org/10.1378/chest.14-1481

10. Canning B.J. Afferent nerves regulating the cough reflex: Mechanisms and Mediators of Cough in Disease. Otolaryngol. Clin. North Am., 2010, vol. 1, no. 43, pp. 15-25, vii. https://doi.org/10.1016/j.otc.2009.11.012

11. Canning B.J. Central regulation of the cough reflex: therapeutic implications. Pulm. Pharmacol. Ther., 2009, no. 22, pp. 75-81. https://doi.org/10.1016/j.pupt.2009.01.003

12. Choudry N.B., Fuller R.W. Sensitivity of the cough reflex in patients with chronic cough. Eur. Respir. J., 1992, no. 5, pp. 296-300.

13. Chung K.F., Canning B., McGarvey L. Eight International London Cough Symposium 2014: Cough hypersensitivity syndrome as the basis for chronic cough. Pulm. Pharmacol. Ther., 2015, no. 35, pp. 76-80. https://doi.org/10.1016/j.pupt.2015.08.009

14. Chung K.F., Pavord I.D. Prevalence, pathogenesis, and causes of chronic cough. Lancet, 2008, vol. 9621, no. 371, pp. 1364-1374. https://doi.org/10.1016/S0140-6736(08)60595-4

15. Chung K.F. Approach to chronic cough: the neuropathic basis for cough hypersensitivity syndrome. J. Thorac. Dis., 2014, no. 6, pp. 699-707. https://doi.org/10.3978/j.issn.2072-1439.2014.08.41

16. Chung K.F. Cough: potential pharmacological developments. EXpert. Opin. Investig. Drugs, 2002, no. 11, pp. 955-963. https://doi.org/10.1517/13543784.11.7.955

17. Dicpinigaitis P.V., Canning B.J., Garner R., Paterson B. Effect of memantine on cough reflex sensitivity: translational studies in guinea pigs and humans. J. Pharmacol. Exp. Ther., 2015, vol. 3, no. 352, pp. 448-454. https://doi.org/10.1124/jpet.114.221218

18. Dicpinigaitis P.V., Dobkin J.B., Rauf K., Aldrich T.K. Inhibition of capsaicin-induced cough by the gamma-aminobutyric acid agonist baclofen. J. Clin. Pharmacol., 1998, no. 38, pp. 364-367. https://doi.org/10.1002/j.1552-4604.1998.tb04436.x

19. Dicpinigaitis P.V. Use of baclofen to suppress cough induced by angiotensin-converting enzyme inhibitors. Ann. Pharmacother., 1996, no. 30, pp. 1242-1245. https://doi.org/10.1177/106002809603001106

20. Driessen A.K., McGovern A.E., Narula M., Yang S.K., Keller J.A., Farrell M.J., Mazzone S.B. Central mechanisms of airway sensation and cough hypersensitivity. Pulm. Pharmacol. Ther., 2017, no. 47, pp. 9-15. https://doi.org/10.1016/j.pupt.2017.01.010

21. Ebihara S., Ebihara T., Kanezaki M., Gui P., Yamasaki M., Arai H., Kohzuki M. Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers. Cough, 2011, no. 7, pp. 3. https://doi.org/10.1186/1745-9974-7-3

22. Eccles R. Central mechanisms IV: conscious control of cough and the placebo effect. Handb. EXp. Pharmacol., 2009, no. 187, pp. 241-262. https://doi.org/10.1007/978-3-540-79842-2_12

23. Escamilla R., Roche N. Cough hypersensitivity syndrome: towards a new approach to chronic cough. European Respiratory Journal, 2014, no. 44, pp. 1103-1106. https://doi.org/10.1183/09031936.00150614

24. Gibson P., Wang G., McGarvey L., Vertigan A.E., Altman K.W., Birring S.S., CHEST Expert Cough Panel. Treatment of unexplained chronic cough: Chest guideline and expert panel report. Chest, 2016, no. 149, pp. 27-44. https://doi.org/10.1378/chest.15-1496

25. Haque R.A., Usmani O.S., Barnes P.J. Chronic idiopathic cough: a discrete clinical entity? Chest, 2005, no. 127, pp. 1710-1713. https://doi.org/10.1378/chest.127.5.1710

26. Hilton E., Marsden P., Thurston A., Kennedy S., Decalmer S., Smith J.A. Clinical features of the urge-to-cough in patients with chronic cough. Respiratory Medicine, 2015, no. 109, pp. 701-707. https://doi.org/10.1016/j.rmed.2015.03.011

27. Kardos P., Dinh Q.T., Fuchs K.H., Gillissen A., Klimek L., Koehler M., Sitter H., Worth H. German Respiratory Society guidelines for diagnosis and treatment of adults suffering from acute, subacute and chronic cough. Respir. Med., 2020, no. 170, pp. 105939. https://doi.org/10.1016/j.rmed.2020.105939

28. Kardos P. Chronic idiopathic cough. Dtsch. Med. Wochenschr., 2017, no. 142, pp. 197-200. https://doi.org/10.1055/s-0042-121765

29. Kauffmann F., Varraso R. The epidemiology of cough. Pulm. Pharmacol. Ther., 2011, no. 24, pp. 289-294. https://doi.org/10.1016/j.pupt.2010.10.012

30. Lee K.K., Birring S.S. Cough and sleep. Lung, 2010, no. 188, suppl. 1, pp. 91-94. https://doi.org/10.1007/s00408-009-9176-0

31. Lee K.K., Davenport P.W., Smith J.A., Irwin R.S., McGarvey L., Mazzone S.B., Birring S.S., CHEST Expert Cough Panel. Global Physiology and Pathophysiology of Cough. Part 1. Cough Phenomenology – CHEST Guideline and Expert Panel Report. Chest, 2021, vol. 1, no. 159, pp. 282-293. https://doi.org/10.1016/j.chest.2020.08.2086

32. Lee S.P., Lee S.M., Lee B.J., Kang S.Y. Effectiveness and safety of codeine and levodropropizine in patients with chronic cough. J. Korean Med. Sci., 2022, vol. 36, no. 37, pp. e275. https://doi.org/10.3346/jkms.2022.37.e275

33. Macedo P., Zhang Q., Saito J., Liang Z., Ffolkes L., Nicholson A.G., Chung K.F. Analysis of bronchial biopsies in chronic cough. Respir. Med., 2017, no. 127, pp. 40-44. https://doi.org/10.1016/j.rmed.2017.04.001

34. Mazzone S.B., McLennan L., McGovern A.E., Egan G.F., Farrell M.J. Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging. Am. J. Respir. Crit. Care Med., 2007, vol. 4, no. 176, pp. 327-332. https://doi.org/10.1164/rccm.200612-1856OC

35. Pasternak G.W., Pan Y-X. Mu Opioids and their receptors: evolution of a concept. Pharmacol. Rev., 2013, vol. 4, no. 65, pp. 1257-1317. https://doi.org/10.1124/pr.112.007138

36. Plevkova J., Kollarik M., Poliacek I., Brozmanova M., Surdenikova L., Tatar M., Mori N., Canning B.J. The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol. J. Appl. Physiol., 2013, no. 115, pp. 268-274. https://doi.org/10.1152/japplphysiol.01144.2012

37. Ryan N.M., Gibson P.G., Birring S.S. Arnold's nerve cough reflex: evidence for chronic cough as a sensory vagal neuropathy. J. Thorac. Dis., 2014, no. 6, suppl. 7, pp. 748-752. https://doi.org/10.3978/j.issn.2072-1439.2014.04.22

38. Smith J., Houghton L. The esophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes. Cough, 2013, no. 9, pp. 12. https://doi.org/10.1186/1745-9974-9-12

39. Song W.J., Chang Y.S., Faruqi S., Kim J.Y., Kang M.G., Kim S., Jo E.J., Kim M.H., Plevkova J., Park H.W., Cho S.H., Morice A.H. The global epidemiology of chronic cough in adults: a systematic review and meta-analysis. Eur. Respir. J., 2015, no. 45, pp. 1479-1481. https://doi.org/10.1183/09031936.00218714

40. Song W.J., Morice A.H. Cough hypersensitivity syndrome: a few more steps forward. Allergy Asthma Immunol. Res., 2017, no. 9, pp. 394-402. https://doi.org/10.4168/aair.2017.9.5.394

41. Undem B.J., Carr M.J. Targeting primary afferent nerves for novel antitussive therapy. Chest, 2010, no. 137, pp. 177-184. https://doi.org/10.1378/chest.09-1960

42. Vertigan A.E., Bone S.L., Gibson P.G. Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome. Respirology, 2013, no. 18, pp. 948-956. https://doi.org/10.1111/resp.12103

43. Widdicombe J. Functional morphology and physiology of pulmonary rapidly adapting receptors (RARs). Anat. Rec. A Discov. Mol. Cell Evol. Biol., 2003, no. 270, pp. 2-10. https://doi.org/10.1002/ar.a.10003

44.


Review

For citations:


Budnevskiy A.V., Avdeev S.N., Ovsyannikov E.S., Feygelman S.N. A Modern View of Cough Pathophysiology. Tuberculosis and Lung Diseases. 2024;102(6):118-126. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-6-118-126

Views: 313


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)