Signs of Electrophysiological Myocardial Remodeling in Respiratory Tuberculosis Patients according to Daily ECG Monitoring Data
https://doi.org/10.58838/2075-1230-2025-103-1-14-22
Abstract
The objective: to optimize diagnostics of cardiovascular disorders in respiratory tuberculosis patients during anti-tuberculosis therapy.
Subjects and Methods. A total of 93 patients with pulmonary tuberculosis without concomitant cardiovascular diseases (CVD) were examined. Daily electrocardiogram monitoring was performed for at least 24 hours using 3 leads. The parameters of the myocardial repolarization were analyzed. The results of the study were processed using MS EXCEL 2016 for Windows and STATISTICA 10 by nonparametric methods.
Results. Various signs of electrophysiological remodeling (ER) combining with each other were identified. Most often, these changes were expressed in hyperadaptation of QT to heart rate and decrease in dQT and Tp-e values. Increased QTcFmin, dQT, Tp-e were rare. Elevated values of the iCEB index were more often detected in patients with a higher average daily QT duration. No statistically significant differences in ER indices were found between the groups of patients with limited and widespread tuberculosis. Patients with respiratory tuberculosis should have their QT dynamics analyzed and signs of ER should not be limited to QT interval testing alone. QT changes do not depend on the degree of pulmonary tuberculosis dissemination.
Supporting agencies: he study had no sponsorship support (the authors used own resources). The article was prepared during the implementation of Research no. 122041200022-2.
About the Authors
A. I. Nagaev
Central Tuberculosis Research Institute
Russian Federation
Andrey I. Nagaev - Cardiologist of Center for Respiratory Diseases Diagnosis and Rehabilitation
Russian Federation
Andrey I. Nagaev - Cardiologist of Center for Respiratory Diseases Diagnosis and Rehabilitation
2 Yauzskaya Alleya, Moscow, 107564 Phone: +7 (499) 785-90-05
E. A. Shergina
Central Tuberculosis Research Institute
Russian Federation
Elena A. Shergina - Candidate of Medical Sciences, Head of Functional Diagnostic Department of Center for Diagnosis and Rehabilitation of Respiratory Diseases
Russian Federation
Elena A. Shergina - Candidate of Medical Sciences, Head of Functional Diagnostic Department of Center for Diagnosis and Rehabilitation of Respiratory Diseases
2 Yauzskaya Alleya, Moscow, 107564 Phone: +7 (499) 785-90-05
N. L. Karpina
Central Tuberculosis Research Institute
Russian Federation
Nataliya L. Karpina - Doctor of Medical Sciences, Deputy Director for Research
Russian Federation
Nataliya L. Karpina - Doctor of Medical Sciences, Deputy Director for Research
2 Yauzskaya Alleya, Moscow, 107564 Phone: +7 (499) 785-90-05
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Review
For citations:
Nagaev A.I., Shergina E.A., Karpina N.L. Signs of Electrophysiological Myocardial Remodeling in Respiratory Tuberculosis Patients according to Daily ECG Monitoring Data. Tuberculosis and Lung Diseases. 2025;103(1):14-22. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-1-14-22
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