Immunological and Genetic Features of the Human Body Associated with Respiratory Mycobacteriosis (Literature Review)
https://doi.org/10.58838/2075-1230-2025-103-1-94-101
Abstract
This review presents publications on the immunopathogenesis of nontuberculous mycobacteria (NTMB). The publications were selected according to the PRISMA design from international and Russian databases (PubMed, elibrary) using the keywords “non-tuberculous mycobacteriosis”, “immunology”, “genetics”, “diagnostics” in accordance with the MeSH classifier. A total of 50 literature sources were found and analyzed. We identidied main directions in the study of mycobacterial infection pathogenesis, risk factors among immunocompetent individuals, and genetic features of predisposition to mycobacteriosis.
About the Authors
A. D. Egorova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Anna D. Egorova - Junior Researcher of Center for Respiratory Diseases Diagnosis and Rehabilitation
2 Yauzskaya Alleya, Moscow, 107564 Phone: +7 (499) 785-90-05
N. L. Karpina
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Nataliya L. Karpina - Doctor of Medical Sciences, Deputy Director for Research, Head of Center for Respiratory Diseases Diagnosis and Rehabilitation
2 Yauzskaya Alleya, Moscow, 107564 Phone: +7 (499) 785-90-05
V. V. Yeremeev
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Vladimir V. Yeremeev - Doctor of Medical Sciences, Head of Immunology Department
2 Yauzskaya Alleya, Moscow, 107564 Phone: +7 (499) 785-90-05
References
1. Borisova O.V., Mordyk A.V. Epidemiology, clinical manifestations, diagnosis and treatment of mycobacteriosis (literature review). Meditsinsky Alyans, 2019, no. 2, pp. 35-45. (In Russ.)
2. Larionova E.E., Andrievskaya I.Yu., Andreevskaya S.N., Smirnova T.G., Chernousova L.N. Microbiological diagnosis of coincident mycobacterial infection in cystic fibrosis. Uralskiy Meditsinskiy Journal, 2018, no. 8, pp. 163. (In Russ.) https://doi.org/10.25694/URMJ.2018.05.54
3. EACS Guidelines, Version 11.00. (In Russ.) October 2021. Available: http://hivlife.info/files/HAART/GUIDELINES/EACS_Guidelines_v11.0_RUS.pdf Accessed December 01, 2024.
4. Ushkov A.D., Azarov A.A., Archakova L.I. Disseminated lung damage with non-tuberculous mycobacteriosis (Lady Windermere syndrome). Meditsinsky Alyans, 2020, vol. 8, no. 1, pp. 75-79. (In Russ.) https://doi.org/10.36422/23076348-2020-8-1-75-79
5. Abidin N.Z., Gardner A.I., Robinson H.L., Haq I.J., Thomas M.F., Brodlie M. Trends in nontuberculous mycobacteria infection in children and young people with cystic fibrosis // J Cyst Fibros. – 2021. – Vol. 20, № 5. – Р. 737-741. https://doi.org/10.1016/j.jcf.2020.09.007
6. Abubakar I., Gupta R.K., Rangaka M.X., Lipman M. Update in Tuberculosis and Nontuberculous Mycobacteria 2017 // Am J Respir Crit Care Med. – 2018. – Vol. 197, № 10. – Р. 1248-1253. https://doi.org/10.1164/rccm.201801-0106UP
7. Adjemian J., Daniel-Wayman S., Ricotta E., Prevots D.R. Epidemiology of Nontuberculous Mycobacteriosis. – Semin Respir Crit Care Med. – 2018. – Vol. 39, № 3. – Р. 325-335. https://doi.org/10.1055/s-0038-1651491
8. Aoki A., Sakagami T., Yoshizawa K., Shima K., Toyama M., Tanabe Y., Moro H., Aoki N., Watanabe S., Koya T., Hasegawa T., Morimoto K., Kurashima A., Hoshino Y., Trapnell B.C., Kikuchi T. Clinical Significance of Interferon-γ Neutralizing Autoantibodies Against Disseminated Nontuberculous Mycobacterial Disease // Clin Infect Dis. – 2018. – Vol. 66, № 8. – Р. 1239-1245. https://doi.org/10.1093/cid/cix996
9. Axson E.L., Bual N., Bloom C.I., Quint J.K. Risk factors and secondary care utilisation in a primary care population with non-tuberculous mycobacterial disease in the UK // Eur J Clin Microbiol Infect Dis. – 2019. – Vol. 38, № 1. – Р. 117-124. https://doi.org/10.1007/s10096-018-3402-8
10. Bai X., Bai A., Honda J.R., Eichstaedt C., Musheyev A., Feng Z., Huitt G., Harbeck R., Kosmider B., Sandhaus R.A., Chan E.D. Alpha-1-Antitrypsin Enhances Primary Human Macrophage Immunity Against Non-tuberculous Mycobacteria // Front Immunol. – 2019. – № 10. – Р. 1417. https:// doi.org/10.3389/fimmu.2019.01417
11. Bruno Ali, Lopez-Luis B.A., Sifuentes-Osornio J., Pérez-Gutiérrez M.T., Chávez-Mazari B., Bobadilla-Del-Valle M., Ponce-de-León A. Nontuberculous mycobacterial infection in a tertiary care center in Mexico, 2001-2017 // Braz J Infect Dis. – 2020. – Vol. 24, № 3. – Р. 213-220. https://doi.org/10.1016/j.bjid.2020.04.012
12. Carneiro MD.S., Nunes L.S., David SM.M., Dias C.F., Barth A.L., Unis G. Nontuberculous mycobacterial lung disease in a high tuberculosis incidence setting in Brazil // J Bras Pneumol. – 2018. – Vol. 44, № 2. – Р. 106-111. https://doi.org/10.1590/s1806-37562017000000213
13. Cornelissen H.M., Glanzmann B., Van Coller A., Engelbrecht C., Abraham D.R., Reddy K., Möller M., Kinnear C., Glashoff R.H., Esser M. Mendelian susceptibility to mycobacterial disease in tuberculosis-hyperendemic South Africa // S Afr Med J. – 2021. – Vol. 111, № 10. – Р. 998-1005. https:// doi.org/10.7196/SAMJ.2021.v111i10.15341
14. Cowman S.A., Jacob J., Hansell D.M., Kelleher P., Wilson R., Cookson W.O.C., Moffatt M.F., Loebinger M.R. Whole-Blood Gene Expression in Pulmonary Nontuberculous Mycobacterial Infection // Am J Respir Cell Mol Biol. – 2018. – Vol. 58, № 4. – Р. 510-518. https://doi.org/10.1165/rcmb.2017-0230OC
15. Cowman S., van Ingen J., Griffith D.E., Loebinger M.R. Non-tuberculous mycobacterial pulmonary disease // Eur Respir J. – 2019. – Vol. 54, № 1. – Р. 1900250. https://doi.org/10.1183/13993003.00250-2019
16. Daley C.L., Iaccarino J.M., Lange C., Cambau E., Wallace R.J., Andrejak C., Böttger E.C., Brozek J., Griffith D.E., Guglielmetti L., Huitt G.A., Knight S.L., Leitman P., Marras T.K., Olivier K.N., Santin M., Stout J.E., Tortoli E., van Ingen J., Wagner D., Winthrop K.L. Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline // Clin Infect Dis. – 2020. – Vol. 71, № 4. – Р. 905-913. https://doi.org/10.1093/cid/ciaa1125
17. Feng Z., Bai X., Wang T., Garcia C., Bai A., Li L., Honda J.R., Nie X., Chan E.D. Differential Responses by Human Macrophages to Infection With Mycobacterium tuberculosis and Non-tuberculous Mycobacteria // Front Microbiol. – 2020. – № 11. – Р. 116. https://doi.org/10.3389/fmicb.2020.00116
18. Ge G., Jiang H., Xiong J., Zhang W., Shi Y., Tao C., Wang H. Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection // Front Immunol. – 2021. – № 12. – Р. 752657. https://doi.org/10.3389/fimmu.2021.752657
19. Ghanavi J., Farnia P., Farnia P., Velayati A.A. The role of interferon-gamma and interferon-gamma receptor in tuberculosis and nontuberculous mycobacterial infections // Int J Mycobacteriol. – 2021. – Vol. 10, № 4. – Р. 349-357. https://doi.org/10.4103/ijmy.ijmy_186_21
20. Gopalaswamy R., Shanmugam S., Mondal R., Subbian S. Of tuberculosis and non-tuberculous mycobacterial infections - a comparative analysis of epidemiology, diagnosis and treatment // J Biomed Sci. – 2020. – Vol. 27, № 1. – Р. 74. https://doi.org/10.1186/s12929-020-00667-6
21. Han S.A., Jhun B.W., Kim S.Y., Moon S.M., Yang B., Kwon O.J., Daley C.L., Shin S.J., Koh W.J. miRNA Expression Profiles and Potential as Biomarkers in Nontuberculous Mycobacterial Pulmonary Disease // Sci Rep. – 2020. – Vol. 10, № 1. – Р. 3178. https://doi.org/10.1038/s41598-020-60132-0
22. Holt M.R., Kasperbauer S.H., Koelsch T.L., Daley C.L. Similar characteristics of nontuberculous mycobacterial pulmonary disease in men and women // Eur Respir J. – 2019. – Vol. 54, № 1. – Р. 1900252. https://doi.org/10.1183/13993003.00252-2019
23. Holt M.R., Miles J.J., Inder W.J., Thomson R.M. Exploring immunomodulation by endocrine changes in Lady Windermere syndrome // Clin Exp Immunol. – 2019. – Vol. 196, № 1. – Р. 28-38. https://doi.org/10.1111/cei.13265
24. Hu W., Spaink H.P. The Role of TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target // Biology (Basel). – 2022. – Vol. 11, № 2. – Р. 246. https://doi.org/10.3390/biology11020246
25. Jones M.M., Winthrop K.L., Nelson S.D., Duvall S.L., Patterson O.V., Nechodom K.E., Findley K.E., Radonovich L.J.Jr., Samore M.H., Fennelly K.P. Epidemiology of nontuberculous mycobacterial infections in the U.S. Veterans Health Administration // PLoS One. – 2018. – Vol. 13, № 6. – Р. e0197976. https://doi.org/10.1371/journal.pone.0197976
26. Kobayashi T., Kuronuma K., Saito A., Ikeda K., Ariki S., Saitou A., Otsuka M., Chiba H., Takahashi S., Takahashi M., Takahashi H. Insufficient serum L-ficolin is associated with disease presence and extent of pulmonary Mycobacterium avium complex disease // Respir Res. – 2019. – Vol. 20, № 1. – Р. 224. https://doi.org/10.1186/s12931-019-1185-9
27. Koh W.J. Nontuberculous Mycobacteria-Overview // Microbiol Spectr. – 2017. – Vol. 5, № 1. https://doi.org/10.1128/microbiolspec
28. Kumfer A.M., Edriss H. Lady Windermere syndrome // The Southwest Respiratory and Critical Care Chronicles. – 2017. – Vol. 5, № 20. – Р. 22-32. https://doi.org/10.12746/swrccc.v5i20.402
29. Lai H.C., Chang C.J., Lin C.S., Wu T.R., Hsu Y.J., Wu T.S., Lu J.J., Martel J., Ojcius D.M., Ku C.L., Young J.D., Lu C.C. // NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection. – J Immunol. – 2018. – Vol. 201, № 5. – Р. 1478-1490. https://doi.org/10.4049/jimmunol.1800123
30. Le Voyer T., Neehus A.L., Yang R., Ogishi M., Rosain J., Alroqi F., Alshalan M., Blumental S., Al Ali F., Khan T., Ata M., Rozen L., Demulder A., Bastard P., Gruber C., Roynard M., Seeleuthener Y., Rapaport F., Bigio B., Chrabieh M., Sng D., Berteloot L., Boddaert N., Rozenberg F., Al-Muhsen S., Bertoli-Avella A., Abel L., Bogunovic D., Marr N., Mansouri D., Al Mutairi F., Béziat V., Weil D., Mahdaviani S.A., Ferster A., Zhang S.Y., Reversade B., Boisson-Dupuis S., Casanova J.L., Bustamante J. Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease // Proc Natl Acad Sci U S A. – 2021. – Vol. 118, № 15. – Р. e2102804118. https:// doi.org/10.1073/pnas.2102804118
31. Lim S.Y., Lee Y.J., Park J.S., Cho Y.J., Yoon H.I., Lee C.T., Lee J.H. Association of lowfat mass with nontuberculous mycobacterial infection in patients with bronchiectasis // Medicine (Baltimore). – 2021. – Vol. 100, № 14. – Р. e25193. https://doi.org/10.1097/MD.0000000000025193
32. Liu V.X., Winthrop K.L., Lu Y., Sharifi H., Nasiri H.U., Ruoss S.J. Association between Inhaled Corticosteroid Use and Pulmonary Nontuberculous Mycobacterial Infection // Ann Am Thorac Soc. – 2018. – Vol. 15, № 10. – Р. 1169-1176. https://doi.org/10.1513/AnnalsATS.201804-245OC
33. Longworth S.A., Daly J.S. AST Infectious Diseases Community of Practice. Management of infections due to nontuberculous mycobacteria in solid organ transplant recipients-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice // Clin Transplant. – 2019. – Vol. 33, № 9. – Р. e13588. https://doi.org/10.1111/ctr.13588
34. Matsuyama M., Martins A.J., Shallom S., Kamenyeva O., Kashyap A., Sampaio E.P., Kabat J., Olivier K.N., Zelazny A.M., Tsang J.S., Holland S.M. Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria // Am J Respir Cell Mol Biol. – 2018. – Vol. 58, № 2. – Р. 241-252. https://doi.org/10.1165/rcmb.2017-0218OC
35. Namkoong H., Omae Y., Asakura T., Ishii M., Suzuki S., Morimoto K., Kawai Y., Emoto K., Oler A.J., Szymanski E.P., Yoshida M., Matsuda S., Yagi K., Hase I., Nishimura T., Sasaki Y., Asami T., Shiomi T., Matsubara H., Shimada H., Hamamoto J., Jhun B.W., Kim S.Y., Huh H.J., Won H.H., Ato M., Kosaki K., Betsuyaku T., Fukunaga K., Kurashima A., Tettelin H., Yanai H., Mahasirimongkol S., Olivier K.N., Hoshino Y., Koh W.J., Holland S.M., Tokunaga K., Hasegawa N. Nontuberculous Mycobacteriosis and Bronchiectasis – Japan Research Consortium (NTM-JRC). Genome-wide association study in patients with pulmonary Mycobacterium avium complex disease // Eur Respir J. – 2021. – Vol. 58, № 2. – Р. 1902269. https://doi.org/10.1183/13993003.02269-2019
36. Oh J., Park H.D., Kim S.Y., Koh W.J., Lee S.Y. Assessment of Vitamin Status in Patients with Nontuberculous Mycobacterial Pulmonary Disease: Potential Role of Vitamin A as a Risk Factor // Nutrients. – 2019. – Vol. 11, № 2. – Р. 343. https://doi.org/10.3390/nu11020343
37. Okoi C., Anderson S.T.B., Antonio M., Mulwa S.N., Gehre F., Adetifa I.M.O. Non-tuberculous Mycobacteria isolated from Pulmonary samples in sub-Saharan Africa - A Systematic Review and Meta Analyses // Sci Rep. – 2017. – Vol. 7, № 1. – Р. 12002. https://doi.org/10.1038/s41598-017-12175-z
38. Park S.C., Kang M.J., Han C.H., Lee S.M., Kim C.J., Lee J.M., Kang Y.A. Prevalence, incidence, and mortality of nontuberculous mycobacterial infection in Korea: a nationwide population-based study // BMC Pulm Med. – 2019. – Vol. 19, № 1. – Р. 140. https://doi.org/10.1186/s12890-019-0901-z
39. Pattabiraman G., Panchal R., Medvedev A.E. The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2 // J Biol Chem. – 2017. – Vol. 292, № 25. – Р. 10685-10695. https://doi.org/10.1074/jbc.M117.784470
40. Phoompoung P., Ankasekwinai N., Pithukpakorn M., Foongladda S., Umrod P., Suktitipat B., Mahasirimongkol S., Kiertiburanakul S., Suputtamongkol Y. Factors associated with acquired Anti IFN- γ autoantibody in patients with nontuberculous mycobacterial infection // PLoS One. – 2017. – Vol. 12, № 4. – Р. e0176342. https://doi.org/10.1371/journal.pone.0176342
41. Prasla Z., Sutliff R.L., Sadikot R.T. Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections // Am J Respir Cell Mol Biol. – 2020. – Vol. 63, № 2. – Р. 144-151. Р. 10.1165/rcmb.2019-0241TR
42. Ratnatunga C.N., Lutzky V.P., Kupz A., Doolan D.L., Reid D.W., Field M., Bell S.C., Thomson R.M., Miles J.J. The Rise of Non-Tuberculosis Mycobacterial Lung Disease // Front Immunol. – 2020. – № 11. – Р. 303. https://doi.org/10.3389/fimmu.2020.00303
43. Sharma S.K., Upadhyay V. Epidemiology, diagnosis & treatment of non-tuberculous mycobacterial diseases // Indian J Med Res. – 2020. – Vol. 152, № 3. – Р. 185-226. https://doi.org/10.4103/ijmr.IJMR_902_20
44. Shteinberg M., Stein N., Adir Y., Ken-Dror S., Shitrit D., Bendayan D., Fuks L., Saliba W. Prevalence, risk factors and prognosis of nontuberculous mycobacterial infection among people with bronchiectasis: a population survey // Eur Respir J. – 2018. – Vol. 51, № 5. –Р. 1702469. https:// doi.org/10.1183/13993003.02469-2017
45. Shu C.C., Wu M.F., Pan S.W., Wu T.S., Lai H.C., Lin M.C. Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease // J Formos Med Assoc. – 2020. – Vol. 119, Suppl 1. – Р. S13-S22. https://doi.org/10.1016/j.jfma.2020.05.001
46. Taur P.D., Gowri V., Pandrowala A.A., Iyengar V.V., Chougule A., Golwala Z., Chandak S., Agarwal R., Keni P., Dighe N., Bodhanwala M., Prabhu S., George B., Fouzia N.A., Edison E.S., Arunachalam A.K., Madkaikar M.R., Dalvi A.D., Yadav R.M., Bargir U.A., Kambli P.M., Rawat A., Das J., Joshi V., Pilania R.K., Jindal A.K., Bhat S., Bhattad S., Unni J., Radhakrishnan N., Raj R., Uppuluri R., Patel S., Lashkari H.P., Aggarwal A., Kalra M., Udwadia Z., Bafna V.S., Kanade T., Puel A., Bustamante J., Casanova J.L., Desai M.M. Clinical and Molecular Findings in Mendelian Susceptibility to Mycobacterial Diseases: Experience From India // Front Immunol. – 2021. – Vol. 25, № 12. – Р. 631298. https://doi.org/10.3389/fimmu.2021.631298
47. Thornton C.S., Mellett M., Jarand J., Barss L., Field S.K., Fisher D.A. The respiratory microbiome and nontuberculous mycobacteria: an emerging concern in human health // Eur Respir Rev. – 2021. – Vol. 30, № 160. – Р. 200299. https://doi.org/10.1183/16000617.0299-2020
48. Wang X., Chen S., Ren H., Chen J., Li J., Wang Y., Hua Y., Wang X., Huang N. HMGN2 regulates non-tuberculous mycobacteria survival via modulation of M1 macrophage polarization // J Cell Mol Med. – 2019. – Vol. 23, № 12. – Р. 7985-7998. https://doi.org/10.1111/jcmm.14599
49. Wright K., de Silva K., Plain K.M., Purdie A.C., Blair T.A., Duggin I.G., Britton W.J., Oehlers S.H. Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis // PLoS Pathog. – 2021. – Vol. 17, № 4. – Р. e1009186. https://doi.org/10.1371/journal.ppat.1009186
50. Xie Y., Xie J., Meijer A.H., Schaaf M.J.M. Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages // Front Immunol. – 2021. – № 12. – Р. 618569. https://doi.org/10.3389/fimmu.2021.618569
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For citations:
Egorova A.D., Karpina N.L., Yeremeev V.V. Immunological and Genetic Features of the Human Body Associated with Respiratory Mycobacteriosis (Literature Review). Tuberculosis and Lung Diseases. 2025;103(1):94-101. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-1-94-101
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