Experimental Evaluation of the Effect of Coenzyme Q10 on Toxicity of a Combination of Antituberculosis Drugs
S. G. Yazeryan,
G. N. Mozhokina,
V. A. Polozkova,
M. I. Treschalin,
E. R. Pereverzeva,
A. G. Samoylova https://doi.org/10.58838/2075-1230-2025-103-2-70-78
Abstract
The objective: to study toxicity modifying effects of Coenzyme Q10 in toxic reactions caused by a combination of antituberculosis drugs in the rat experiment.
Subjects and Methods. 30 non-linear female rats weighing 230-250 g, divided into 3 groups were used in the experiment. Control Group (CG) received 1% starch gel. Experimental Group 1 (EG1) received a combination of 5 antituberculosis drugs: Mxf + Bdq + Lzd + Cs + Z, Experimental Group 2 (EG2) received the same antituberculosis drugs, and additionally Coenzyme Q10 as the drug product of Qudesan, 30 min before the combination of antituberculosis drugs. Doses of antituberculosis drugs and Coenzyme Q10 were equivalent to human therapeutic doses used in the clinic. The manifestation of toxic reactions in rats was evaluated by body weight changes, clinical and biochemical blood parameters, changes in ECG and behavioral reactions in the open field test, and morphological changes in organs and tissues.
Results. Coenzyme Q10 showed the ability to modify cardio-, hepato-, hematoto- and nephrotoxicity induced by antituberculosis drugs at functional and morphologic levels. It was impossible to assess the neuroprotective effect of Coenzyme Q10 in the dose used due to weakly expressed changes in behavioral reactions in rats after the combination of antituberculosis drugs compared to Control Group.
About the Authors
S. G. Yazeryan
G.F. Gause Research Institute for Development of New Antibiotics
Russian Federation
Russian Federation
Sophia G. Yazeryan - Post-Graduate Student
11 Bolshaya Pirogovskaya St., Moscow, 119021
G. N. Mozhokina
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health; G.F. Gause Research Institute for Development of New Antibiotics
Russian Federation
Russian Federation
Galina N. Mozhokina - Doctor of Medical Sciences, Leading Researcher of Laboratory of Immunopathology and Immunodiagnostics of Tuberculosis Infection; Leading Researcher of Pharmacology and Chemotherapy Laboratory
4 Build. 2 Dostoevsky St., Moscow, 127473
Phone: +7 (495) 631-15-15
11 Bolshaya Pirogovskaya St., Moscow, 119021
V. A. Polozkova
G.F. Gause Research Institute for Development of New Antibiotics
Russian Federation
Russian Federation
Vasilisa A. Polozkova - Candidate of Biological Sciences, Researcher
11 Bolshaya Pirogovskaya St., Moscow, 119021
M. I. Treschalin
G.F. Gause Research Institute for Development of New Antibiotics
Russian Federation
Russian Federation
Mikhail I. Treschalin - Candidate of Biological Sciences, Researcher
11 Bolshaya Pirogovskaya St., Moscow, 119021
E. R. Pereverzeva
G.F. Gause Research Institute for Development of New Antibiotics
Russian Federation
Russian Federation
Eleonora R. Pereverzeva - Doctor of Biological Sciences, Chief Researcher
11 Bolshaya Pirogovskaya St., Moscow, 119021
A. G. Samoylova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Anastasiya G. Samoylova - Doctor of Medical Sciences, Deputy Director for Research
4 Build. 2 Dostoevsky St., Moscow, 127473
Phone: +7 (495) 631-15-15
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Review
For citations:
Yazeryan S.G., Mozhokina G.N., Polozkova V.A., Treschalin M.I., Pereverzeva E.R., Samoylova A.G. Experimental Evaluation of the Effect of Coenzyme Q10 on Toxicity of a Combination of Antituberculosis Drugs. Tuberculosis and Lung Diseases. 2025;103(1):70-79. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-2-70-78
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