Метаболомические исследования в пульмонологии
https://doi.org/10.21292/2075-1230-2015-0-2-4-11
Аннотация
В обзоре отражены результаты применения метаболомических исследований в пульмонологии. Ключевая идея метаболомики заключается в обнаружении специфических биомаркеров в биологическом образце для диагностики заболеваний бронхов и легких. Приведены основные методы разделения и идентификации летучих органических веществ как биомаркеров (газовая хроматография, масс-спектрометрия, спектроскопия ядерного магнитного резонанса), применяемые в метаболомике. Также освещен метод твердофазной микроэкстракции, применяемой в качестве предварительной подготовки образца. Представлены результаты лабораторных исследований по поиску биомаркеров рака легких, острого респираторного дистресс-синдрома, хронической обструктивной болезни легких, муковисцедоза, хронических инфекций, туберкулеза легких. Кроме того, уделено внимание применению возможностей метаболомики в экспериментальной медицине, в том числе изучению бронхиальной астмы. Информация интересна как для теоретиков, так и для практикующих врачей.
Об авторе
Р. Р. Фурина
ГБУ РМЭ «Республиканская клиническая больница»
Россия
Россия
врач-эндоскопист эндоскопического отделения,
424030, г. Йошкар-Ола, ул. Осипенко, д. 33
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Рецензия
Для цитирования:
Фурина Р.Р. Метаболомические исследования в пульмонологии. Туберкулез и болезни легких. 2015;(2):4-11. https://doi.org/10.21292/2075-1230-2015-0-2-4-11
For citation:
Furina R.R. Metabolomic studies in pulmonology. Tuberculosis and Lung Diseases. 2015;(2):4-11. (In Russ.) https://doi.org/10.21292/2075-1230-2015-0-2-4-11
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