Metabolomic studies in pulmonology
https://doi.org/10.21292/2075-1230-2015-0-2-4-11
Abstract
The review shows the results of metabolomic studies in pulmonology. The key idea of metabolomics is to detect specific biomarkers in a biological sample for the diagnosis of diseases of the bronchi and lung. Main methods for the separation and identification of volatile organic substances as biomarkers (gas chromatography, mass spectrometry, and nuclear magnetic resonance spectrometry) used in metabolomics are given. A solid-phase microextraction method used to pre-prepare a sample is also covered. The results of laboratory tests for biomarkers for lung cancer, acute respiratory distress syndrome, chronic obstructive pulmonary disease, cystic fibrosis, chronic infections, and pulmonary tuberculosis are presented. In addition, emphasis is placed on the possibilities of metabolomics used in experimental medicine, including to the study of asthma. The information is of interest to both theorists and practitioners.
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Review
For citations:
Furina R.R. Metabolomic studies in pulmonology. Tuberculosis and Lung Diseases. 2015;(2):4-11. (In Russ.) https://doi.org/10.21292/2075-1230-2015-0-2-4-11
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