EFFICIENCY OF DIASKINTEST DURING MASS PROPHYLACTIC EXAMINATIONS IN CHILDREN: PHARMACOECONOMIC ANALYSIS

Abstract

The efficiency of mass screenings for tuberculosis in children and adolescents was determined as a proportion of persons who were found to have tuberculosis. The diagnostic effectiveness of the skin test with recombinant tuberculosis allergen (Diaskintest) was 0.1%; that of traditional diagnosis using purified tuberculosis allergen in standard dilution for intradermal use (2 TU PPD-L) was 0.003%. With the use of a combined regimen (firstly, mass diagnosis with Mantoux test with 2 TU, then additional examination of identified risk groups with the Diaskintest), the efficiency was 0.006%.

The authors made a cost-effectiveness analysis of the skin tests with recombinant tuberculosis allergen (Diaskintest) and purified tuberculosis allergen in standard dilution (2 TU PPD-L) used to diagnose tuberculosis infection in children and adolescents. Pharmacoeconomically, the analysis showed the advantages of the Diaskintest. The cost-effectiveness coefficient of a Diaskintest model was 178,400 rubles; that of the combined regimen and traditional tuberculin diagnosis was 2,573,166 and 4,870,666 rubles, respectively. The lowest cost were required to identify a patent with tuberculosis in the primary diagnosis with Diaskintest.