SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS
https://doi.org/10.21292/2075-1230-2015-0-8-38-42
Abstract
New untreated infiltrate pulmonary tuberculosis patients commonly demonstrated the same referent level of MMP-8, MMP-3 and multiple increase of MMP-9 level on the background of diverse changes of inhibiting potential (retaining the reference level of TIMP-1 and reduced α2 -МG). Destructive process is related to unbalanced increase of рro-ММР-1 and ММР-9. At the same time the level of рro-ММР-1 correlates to changes in ROF, activity of proteinases of other classes (serine proteinases) and depends on the dissemination of the disease, while the changes in MMP-9 level are influenced by the massiveness of bacillary excretion.
About the Authors
D. S. Esmedlyaeva
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
St. Petersburg
Russian Federation
St. Petersburg
O. T. Titarenko
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
St. Petersburg
Russian Federation
St. Petersburg
M. V. Pavlova
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
St. Petersburg
Russian Federation
St. Petersburg
M. E. Dyakova
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
St. Petersburg
Russian Federation
St. Petersburg
T. L. Perova
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
St. Petersburg
Russian Federation
St. Petersburg
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Review
For citations:
Esmedlyaeva D.S., Titarenko O.T., Pavlova M.V., Dyakova M.E., Perova T.L. SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS. Tuberculosis and Lung Diseases. 2015;(8):38-42. (In Russ.) https://doi.org/10.21292/2075-1230-2015-0-8-38-42
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