DRUG RESISTANCE OF STRAINS OF M. TUBERCULOSIS, ISOLATED FROM PULMONARY TUBERCULOSIS PATIENTS IN VLADIMIR REGION IN 2013
Abstract
The study presents the analysis of drug susceptibility of tuberculosis mycobacteria isolated from pulmonary tuberculosis patients by the moment of their registration in 2013 on the territory of Vladimir region. Totally 574 pulmonary tuberculosis patients were registered. Of them 432 were new cases, 78 relapses and other cases (in particular treatment failures and defaults) made 64 persons. All the groups demonstrated the increase of multiple drug resistance: in 101 (28.5%) cases of all infectious patients who had drug susceptibility tests done. Among new cases and relapses – 69 (25.9%) and 24 (46.2%) isolates of tuberculosis mycobacteria respectively.
About the Authors
E. S. Dyuzhik
Center for Specialized of Phthisiopulmonary Care
Russian Federation
Vladimir
Russian Federation
Vladimir
N. V. Kaunetis
Center for Specialized of Phthisiopulmonary Care
Russian Federation
Vladimir
Russian Federation
Vladimir
T. G. Smirnova
Central Tuberculosis Research Institute
Russian Federation
Moscow
Russian Federation
Moscow
E. E. Larionova
Central Tuberculosis Research Institute
Russian Federation
Moscow
Russian Federation
Moscow
G. V. Volchenkov
Center for Specialized of Phthisiopulmonary Care
Russian Federation
Vladimir
Russian Federation
Vladimir
References
1. Gabbasova L.A., Kasaeva T.Ch., Kormacheva E.A. et al. Tuberculosis in the Russian Federation in 2011. Analytic review of statistic rates used in the Russian Federation and in the world. Moscow, Triada Publ., 2013, 280 p.
2. Edict no. 109 by RF MoH as of 21.03.2003 On Improvement of TB Control Measures in the Russian Federation. Moscow, 2003, 347 p.
3. Tuberkulez v Rossiyskoy Federatsii, 2013 g. Analitichesky obzor statisticheskhy pokazateley, ispolzuemykh v Rossiyskoy Federatsii. [Tuberculosis incidence in the Russian Federation, 2013. Analytic review of tuberculosis statistic rates used in the Russian Federation]. Moscow, 2013. pp. 1-14.
4. Fedorova L.S., Yuzbashev V.G., Popov S.A. et al. Sistema infektsionnogo kontrolya v protivotuberkuleznykh uchrezhdeniyakh. [Infection control system in tuberculosis units]. Moscow, Triada Publ., 2013, 137 p.
5. Gandhi N.R., Nunn P., Dheda K. Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis. Lancet, 2010, no. 375, pp. 1830-1843.
6. Diel R., Vandeputte J., Vries G. et al. Costs of tuberculosis disease in the European Union: a systematic analysis and cost calculation. Eur. Respir.J., 2014, pp. 554-565.
7. Kent P.T., Kubica G.P. Public Health Mycobacteriology: A Guide for the Level III Laboratory. US Department of Health and Human Services, Centers for Disease Control, USA. 1985.
8. Migliori G.B., Sotgiu G., Neel R. et al. Drug resistance beyond extensively drug-resistant tuberculosis: individual patient data meta-analysis. Eur. Respir. J., 2013, vol. 42, no. 1, pp. 169-179.
9. Migliori G.B., Sotgiu G., D’Ambrosio L. TB and MDR/XDR-TB in European Union and European Economic Area countries: managed or mismanaged? Eur. Respir. J., 2012, vol. 39, pp. 619-625.
10. Salman H. Siddiqi Guidelines for Second-line Drug Susceptibility Testing in МGIT Based on Published Studies. Critical Concentrations and Procedures. 2014, pp. 28,
11. World Health Organization. Global tuberculosis report 2012. Geneva, World Health Organization. 2012.
12. World Health Organization. Towards universal access to diagnosis and treatment of multidrug-resistant and extensively drug-resistant tuberculosis by 2015. WHO report 2011. Geneva, WHO, 2011.
13. World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis. Geneva, WHO, 2008.
14. World Health Organization. Policy guidance on drug –susceptibility testing (DST) of second-line antituberculosis drugs. Geneva, WHO, 2008.
15. WHO Global tuberculosis report. World Health Organization. Geneva, Switzerland, 2013, pp. 5-259.
16. WHO Global tuberculosis report. World Health Organization. Geneva, Switzerland, 2014, pp. 73.
17. Zumla A., Kim P., Maeurer M. Zero deaths from tuberculosis: progress, reality, and hope. Lancet Infect. Dis., 2013, vol. 13, pp. 285-287.
Review
For citations:
Dyuzhik E.S., Kaunetis N.V., Smirnova T.G., Larionova E.E., Volchenkov G.V. DRUG RESISTANCE OF STRAINS OF M. TUBERCULOSIS, ISOLATED FROM PULMONARY TUBERCULOSIS PATIENTS IN VLADIMIR REGION IN 2013. Tuberculosis and Lung Diseases. 2015;(10):36-41. (In Russ.)
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