IDENTIFICATION OF POLYMORPHOUS VARIANTS OF GENES REGULATING CELLULAR CYCLE IN CASE OF LUNG CANCER
Abstract
The study investigated the distribution of polymorphous variants of genes regulating cellular cycle – p53 G215C, Bax G248A and Bcl-2 C938A in lung cancer patients and healthy donors with the purpose of obtaining new fundamental knowledge on the role of above polymorphisms in the lung cancer development. The statistically significant di|erences were found out in the distribution of polymorphous variants of genes regulating cellular cycle in the compared groups; relative risks of cancer development were calculated for those carrying of polymorphous variants of genes of p53 G215C, Bax G248A and Bcl-2 C938A.
Keywords
About the Authors
A. I. Dmitrieva
Siberian State Medical University;
Tomsk Regional Oncology Dispensary
Russian Federation
Tomsk
Russian Federation
Tomsk
V. A. Serebryakova
Siberian State Medical University;
Tomsk Regional Oncology Dispensary
Russian Federation
Tomsk
Russian Federation
Tomsk
I. A. Kuznetsova
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
S. S. Rakitin
Siberian State Medical University;
Tomsk Regional Oncology Dispensary
Russian Federation
Tomsk
Russian Federation
Tomsk
L. A. Kudyakov
Tomsk Regional Oncology Dispensary
Russian Federation
Tomsk
Russian Federation
Tomsk
V. V. Novitskiy
Siberian State Medical University;
Research Institute of Tomsk State University
Russian Federation
Tomsk
Russian Federation
Tomsk
References
1. Gervas P.A., Cherdyintseva N.V., Belyavskaya V.A. et al. Polymorphism of cancer suppression gene of p53: age factors in the risk of lung cancer development. Sibirsky Onkologichesky Journal, 2007, no. 2, pp. 49-54. (In Russ.)
2. 2, Dmitrieva A.I. Rol’ polimorfnykh genov fermentov biotransformatsii ksenobiotikov i gena p53 v patogeneze onkologicheskikh zabolevaniy. Diss, dokt. med. nauk. [Role of polymorphous genes of xenobiotic biotransformation enzymes and gene p53 in pathogenesis of cancer. Doct. Diss.]. Tomsk, 2009.
3. Kuznetsova I.A., Dmitrieva A.I., Rakitin S.S., Novitskiy V.V. Polymorphism of genes regulating cellular circle of p53 and p21waf1/cip1 in lung cancer. Sibirsky Meditsinksy Journal, 2012, no. 3, pp. 47-50. (In Russ.)
4. Pospelova T.I., Voevoda M.I., Voropaeva E.N. et al. The value of constitutional polymorphism of p53 gene in those suffering from non-Hodgkin malicious lymphomas. Bulleten’ Sibirskoy Meditsiny, 2008, vol. 7, no. 3, pp. 56-62. (In Russ.)
5. 5, Bachmann H.S., Heukamp L.C., Schitz K.J. et al. Regulatory BCL2 promoter polymorphism (-938C > A) is associated with adverse outcome in patients with prostate carcinoma. Int. J. Cancer., 2011, vol. 129, no. 10, pp. 2390-2399.
6. Bonnet S., Archer S.L., Allalunis-Turner J. et al. A mitochondria-k(+) channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell., 2007, vol. 11, no. 1, pp. 37-51.
7. Bourdon J.C. p53 and its isoforms in cancer. Br. J. Cancer. 2006, vol. 97, no. 3, pp. 277-282.
8. Fingas C.D., Katsounas A., Kahraman A. et al. Prognostic assessment of single-nucleotide polymorphisms (GNB3 825C > T, BCL2 -938C > A, MCL1 -386C > G) in extrahepatic cholangiocarcinoma. Cancer Invest., 2010, vol. 28, no. 5, pp. 472-478.
9. Joerger A.C., Fersht A.R. Structure-function-rescue: the diverse nature of common p53 cancer mutants. Oncogene, 2007, vol. 26, no. 15, pp. 2226-2242.
10. Kaderi M.A., Norberg M., Murray F. et al. The Bcl-2 promoter (-938C > A) polymorphism does not predict clinical outcome in chronic lymphocytic leukemia. Leukemia, 2008, vol. 22, no. 2, pp. 339-343.
11. Kang S.Y., Han J.H., Lee K.J. et al. Low expression of Bax predicts poor prognosis in patients with locally advanced esophageal cancer treated with definitive chemoradiotherapy. Clin. Cancer. Res., 2007, vol. 13, no. 14, pp. 4146-4153.
12. Kuznetsova I.A., Yankovich K.I., Rakitin S.S., Dmitrieva A.I. Polymorphism of cell cycle regulating genes Bcl-2 (-938C > A), Bax (-248G > A) and p27 (-326T > G) and the risk of lung cancer. International Journal of Biomedicine, 2012, vol. 2, no. 3, pp. 197-200.
13. Lin H.Y., Huang C.H., Yu T.J. et al. p53 codon 72 polymorphism as a progression
14. index for bladder cancer. Oncol. Rep., 2012, vol. 27, no. 4, pp. 1193-1199.
15. Liu Z., Sun R., Lϋ W. et al. The -938C/A genotype of Bcl-2 gene is associated with esophageal cancer. Medical Oncology, 2011, vol. 28, no. 2, pp. 424-248.
16. Philipp-Staheli J., Kim K.H., Liggitt D. et al. Distinct roles for p53, p27Kip 1, and p21Cip 1 during tumor development. Oncogene, 2004, vol. 23, no. 4, pp. 905-913.
17. Rogler A., Rogenhofer M., Borchardt A. et al. P53 codon 72 (Arg72Pro) polymorphism and prostate cancer risk: association between disease onset and proline genotype. Pathobiology, 2011, vol. 78, no. 4, pp. 193-200.
18. Schmidt M.K., Tommiska J., Broeks A. et al. Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP 309, and p53 expression on survival of breast cancer patients. Breast Cancer Research, 2009, vol. 11, no. 6, pp. 89-101.
19. Shirai O., Ohmiya N., Taguchi A. et al. P53, p21, and p73 gene polymorphisms in gastric carcinoma. Hepatogastroenterology, 2010, vol. 57, no. 104, pp. 1595-1601.
20. Soussi T. p53 alterations in human cancer: more questions than answers. Oncogene, 2007, vol. 26, no. 15, pp. 2145-2156.
21. Soussi T., Wiman K.G. Shaping genetic alterations in human cancer the p53 mutation paradigm. Cancer Cell., 2007, vol. 12, no. 4, pp. 303-312.
22. Vousden, K.H. p53 in health and disease Vousden K.H., Lane D.P. Nat. Rev. Mol. Biol., 2007, vol. 8, no. 4, pp. 275-283.
23. Yu D., Guo Y., Tan W. et al. Functional Bax polymorphism associated with lung cancer susceptibility. Zhonghua Zhong Liu Za Zhi, 2010, vol. 32, no. 5, pp. 324-327.
24. Zenz T., Benner A., Duhrsen U. et al. BCL2 -938C > A polymorphisms and disease progression in chronic lymphocytic leukemia. Leuk. Lymphoma, 2009, vol. 50, no. 11, pp. 1837-1842.
25. Zhang N., Li X., Tao K. et al. Bcl-2 (-938C > A) polymorphism is associated with breast cancer susceptibility. BMC Med. Genet., 2011, vol. 12, pp. 48-51.
Review
For citations:
Dmitrieva A.I., Serebryakova V.A., Kuznetsova I.A., Rakitin S.S., Kudyakov L.A., Novitskiy V.V. IDENTIFICATION OF POLYMORPHOUS VARIANTS OF GENES REGULATING CELLULAR CYCLE IN CASE OF LUNG CANCER. Tuberculosis and Lung Diseases. 2015;(10):50-53. (In Russ.)
Views:
487
Email this article 