Аутофагия в патогенезе туберкулеза
Аннотация
Аутофагия - важный иммунный механизм, определяющий устойчивость организма к внутриклеточным патогенам и, в частности, к микобактерии туберкулеза. При этом аутофагия участвует в непосредственной элиминации патогена, контроле иммунных реакций организма и поддержании внутриклеточного гомеостаза, что важно для персистенции микобактерий. Ингибирование аутофагии на ранних этапах инфицирования вирулентными штаммами микобактерий является одной из причин несостоятельности иммунного ответа, и механизмы, лежащие в основе этого процесса, рассматриваются как перспективная область для поиска патогенетически ориентированных подходов профилактики и терапии туберкулеза.
Об авторах
А. В. Чечушков
ФГБНУ «НИИ экспериментальной и клинической медицины»
Россия
Россия
научный сотрудник,
630117 г. Новосибирск, ул. Тимакова, д. 2
Н. К. Зенков
ФГБНУ «НИИ экспериментальной и клинической медицины»
Россия
Россия
П. М. Кожин
ФГБНУ «НИИ экспериментальной и клинической медицины»
Россия
Россия
Т. А. Колпакова
Новосибирский НИИ туберкулеза МЗ РФ; ГБОУ ВПО «Новосибирский государственный медицинский университет» МЗ РФ
Россия
Россия
Е. Б. Меньщикова
ФГБНУ «НИИ экспериментальной и клинической медицины»
Россия
Россия
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Рецензия
Для цитирования:
Чечушков А.В., Зенков Н.К., Кожин П.М., Колпакова Т.А., Меньщикова Е.Б. Аутофагия в патогенезе туберкулеза. Туберкулез и болезни легких. 2016;94(3):8-19.
For citation:
Chechushkov A.V., Zenkov N.K., Kozhin P.M., Kolpakova T.A., Men'schikova E.B. AUTOPHAGY IN THE PATHOGENESIS OF TUBERCULOSIS. Tuberculosis and Lung Diseases. 2016;94(3):8-19. (In Russ.)
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