AUTOPHAGY IN THE PATHOGENESIS OF TUBERCULOSIS
Abstract
Autophagy is an important immune mechanism defining the host resistance to intracellular pathogens and tuberculous mycobacteria in particular. Autophagy is involved into direct elimination of the pathogenic agent, control of immune reactions of the host and maintenance of intracellular homeostasis which is important for mycobacterial persistence. Inhibition of autophagy at the early stages of infection by virulent mycobacterial strains is one of the reasons of poor immune response, and mechanisms defining this response are considered to be promising field to search for approaches centered at the pathogen for the tuberculosis prevention and treatment.
About the Authors
A. V. Chechushkov
Research Institute of Experimental and Clinical Medicine
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
N. K. Zenkov
ФГБНУ «НИИ экспериментальной и клинической медицины»
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
P. M. Kozhin
ФГБНУ «НИИ экспериментальной и клинической медицины»
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
T. A. Kolpakova
Novosibirsk Tuberculosis Research Institute;
Novosibirsk State Medical University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
E. B. Men'schikova
ФГБНУ «НИИ экспериментальной и клинической медицины»
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
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Chechushkov A.V., Zenkov N.K., Kozhin P.M., Kolpakova T.A., Men'schikova E.B. AUTOPHAGY IN THE PATHOGENESIS OF TUBERCULOSIS. Tuberculosis and Lung Diseases. 2016;94(3):8-19. (In Russ.)
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