TREATMENT EFFICIENCY OF DRUG SUSCEPTIBLE PULMONARY TUBERCULOSIS
https://doi.org/10.21292/2075-1230-2016-94-8-23-29
Abstract
The article describes the study of comparative efficiency of fenazid (isonicotinoilhydrazine-О,N’) ferrous dihydrate sulphate (II) and isoniazid in drug susceptible pulmonary tuberculosis patients.
The high treatment efficiency namely significant improvement and improvement was observed in the patients of Group 1 – 84.1% which could be compared to the standard treatment regimen (85-7%) in Group 2. The total number of adverse reactions in the main group was confidently lower – 18.6% against 33.9%, p < 0.05. Hepatotoxic reactions with 2-3 fold increase of alaninetransferase level was registered significantly less (9.3%) in Group 1 compared to the Group treated with isoniazid.
About the Authors
M. V. Pavlova
St. Petersburg research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of Pulmonary tuberculosis treatment Department,
2-4, ligovsky Ave., St. Petersburg, 191036
I. V. Chernokhaeva
St. Petersburg research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Resident Physician of Pulmonary tuberculosis treatment Department,
2-4, ligovsky Ave., St. Petersburg, 191036
A. A. Starshinova
St. Petersburg research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of Phthisiology Department,
2-4, ligovsky Ave., St. Petersburg, 191036
N. V. Sapozhnikova
St. Petersburg research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Candidate of Medical Sciences, Senior researcher of Pulmonary tuberculosis treatment Department,
2-4, ligovsky Ave., St. Petersburg, 191036
E. N. Belyaeva
St. Petersburg research Institute of Phthisiopulmonology;
Municipal TB Hospital
Russian Federation
Russian Federation
Head of tB treatment Department for Drug resistant Patients, TB Doctor, Junior researcher of Pulmonary tB treatment Department,
2-4, ligovsky Ave., St. Petersburg, 191036
A. L. Chuzhov
St. Petersburg research Institute of Phthisiopulmonology;
Pushkin TB Dispensary
Russian Federation
Russian Federation
TB Doctor of St. Petersburg research institute of Phthisiopulmonology, russian Ministry of Health, Deputy Head Doctor on Medicine,
14, Pavlovskoye rd, Pushkin, 196602
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Review
For citations:
Pavlova M.V., Chernokhaeva I.V., Starshinova A.A., Sapozhnikova N.V., Belyaeva E.N., Chuzhov A.L. TREATMENT EFFICIENCY OF DRUG SUSCEPTIBLE PULMONARY TUBERCULOSIS. Tuberculosis and Lung Diseases. 2016;94(8):23-29. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-8-23-29
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