CHARACTERISTICS OF MYCOBACTERIUM TUBERCULOSIS POPULATION IN KARELIYA REPUBLIC
https://doi.org/10.21292/2075-1230-2016-94-8-48-53
Abstract
Goal of the study: genotyping of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in Kareliya Republic from June 2013 to January 2014.
Results. Spoligotyping of 78 M. tuberculosis strains showed that they belonged to families of Beijing (n = 43), T (n = 11), URAL (n = 10), LAM (n = 8), Haarlem and Х. Eight out of 24 spoligotypes: SIT1 (Beijing); SIT40, SIT52, SIT53 (T); SIT35 и SIT262 (H3/URAL); SIT42 (LAM); SIT50 (Haarlem) were represented by two and more strains. The association between primary multiple resistance and Beijing genotype ofthe mycobacterium was defined, and 43.8% of M. tuberculosis strains of this genotype belonged to В0/W148 cluster which was of the epidemiological and clinical significance. T group was represented by drug susceptible strains only.
About the Authors
A. A. Vyazovaya
Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
Senior researcher of Molecular Microbiology laboratory,
14, Mira St., St. Petersburg, 197101
N. S. Solovieva
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Head of Bacteriological laboratory,
32, Politehknicheskaya St., St. Petersburg, 194064
T. V. Sunchalina
Republican TB Dispensary
Russian Federation
Russian Federation
Biologist,
40, lva tolstogo St., Petrozavodsk, 185000
I. V. Mokrousov
Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
Leading researcher of Molecular Microbiology laboratory,
14, Mira St., St. Petersburg, 197101
V. Yu. Zhuravlev
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Head of laboratory Diagnostics Department;
2-4, ligovsky Ave., St. Petersburg, 191014
O. V. Narvskaya
Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology;
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Head of Molecular Microbiology laboratory,
14, Mira St., St. Petersburg, 197101
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Review
For citations:
Vyazovaya A.A., Solovieva N.S., Sunchalina T.V., Mokrousov I.V., Zhuravlev V.Yu., Narvskaya O.V. CHARACTERISTICS OF MYCOBACTERIUM TUBERCULOSIS POPULATION IN KARELIYA REPUBLIC. Tuberculosis and Lung Diseases. 2016;94(8):48-53. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-8-48-53
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