IMMUNOLOGICAL TESTS IN DIFFERENTIAL DIAGNOSTICS OF PULMONARY TUBERCULOSIS
https://doi.org/10.21292/2075-1230-2017-95-4-26-30
Abstract
Time period required for diagnosis in those with suspected pulmonary tuberculosis was analyzed; diagnostic value of immunological tests done in 70 patients (diaskintest and QuantiFERON®TB Gold) was studied and the results were presented. As a result of this comprehensive examination 20 patients were diagnosed with tuberculosis and 50 patients were diagnosed with non-tuberculosis diseases. The analysis has proved high sensitivity of diaskintest – 75%, QuantiFERON®TB Gold – 90% and their specificity is 86 and 84% respectively. The factors associated with positive results of both tests have been detected.
About the Authors
V. A. Krasnov
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical Sciences,
81a, Okhotskaya St., Novosibirsk, 630040
T. I. Petrenko
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical Sciences,
81a, Okhotskaya St., Novosibirsk, 630040
References
1. Balabanova Ya.M., Kryukov N.N., Kuznetsov S.I. et al. Evaluation of variations in the chest X-ray interpretation in diagnostics of tuberculosis and other respiratory diseases. Sibir. Med. Journal, 2005, no. 1, pp. 48-52. (In Russ.)
2. Vasilieva E.V., Pauker M.N., Gritsayj I.Yu. et al. Advantages and limitations of QuantiFERON-TB GOLD IN-TUBE in laboratory diagnostics of pulmonary tuberculosis. Tuberculosis and Lung Diseases, 2013, no. 2, pp. 13-17. (In Russ.)
3. Karpina N., Posazhennikova S., Perfiliev А., Lepekha L., Demikhova O. Diagnostic errors when assessing infiltrate changes in the lungs. Vrach, 2015, no. 7. pp. 59-62. (In Russ.)
4. Kulchavenya E.V., Brizhatyuk E.V., Koveshnikova E.Yu., Sveshnikova N.N. New tendencies in the epidemic situation of extrapulmonary tuberculosis in Siberia and Far East. Tuberculosis and Lung Diseases, 2009, no. 10, pp. 27-31. (In Russ.)
5. Kulchavenya E.V., Krasnov V.А., Skornyakov S.N. et al. Current tendencies of epidemiological situation of extrapulmonary tuberculosis. Tuberculosis and Lung Diseases, 2013, no. 12, pp. 34-38. (In Russ.)
6. Laushkina Zh.А., Filimonov P.N. Overdiagnosis of tuberculosis in those with malignant pulmonary tumors. Tuberculosis and Lung Diseases, 2014, no. 5, pp. 56-59. (In Russ.)
7. Neyshtadt А.S., Ivanovsky V.B., Pauker M.N. Stages and quality of clinical diagnostics of lingering pneumonia in tuberculosis in-patient department. Klin. Meditsina, 2011, no. 1, pp. 31-34. (In Russ.)
8. Nikolaeva G.M. Diagnostika disseminirovannogo tuberkuleza i drugikh granulematoznykh zabolevaniy. Diss. dokt. med. nauk. [Diagnostics of disseminated tuberculosis and other granulematous diseases. Doct. Diss.]. Moscow, 2004. 44 p.
9. Slogotskaya L.V. Effektivnost kozhnogo testa s allergenom tuberkuleznym, soderzhaschim rekombinantniy belok ESAT6 CFP10 v diagnostike, vyavlenii i opredelnii aktivnosti tuberkuleznoy infektsii. Avtoref. diss. dokt. med. nauk. [Efficiency of skin test with tuberculous allergen containing recombinant protein of ESAT6 CFP10 for diagnostics, detection and defining of the tuberculous infection activity. Doct. Diss.]. Moscow, 2011, 45 p.
10. Al-Zamel F.A. Detection and diagnosis of Mycobacterium tuberculosis. Expert. Rev. Anti. Infect. Ther., 2009,no. 7 (9), pp. 1099-108.
11. Guglielmetti L., Conti M., Cazzadori A., Lo Cascio G., Sorrentino A., Concia E. Diagnostic sensitivity of QuantiFERON-TB Gold In-Tube and tuberculin skin test in active tuberculosis: influence of immunocompromission and radiological extent of disease. Infez. Med., 2012, no. 20 (1), pp. 16-24.
12. Gupta D. et al. Sarcoidosis and tuberculosis: the same disease with different manifestations or similar manifestations of different disorders. Curr. Opin. Pulm. Med., 2012, no. 18 (5), pp. 506-516.
13. Tigges S., Roberts D.L., Vydareny K.H., Schulman D.A. Routine chest radiography in a primary care setting. Radiology, 2004, no. 2, pp. 575-578.
Review
For citations:
Krasnov V.A., Petrenko T.I. IMMUNOLOGICAL TESTS IN DIFFERENTIAL DIAGNOSTICS OF PULMONARY TUBERCULOSIS. Tuberculosis and Lung Diseases. 2017;95(4):26-30. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-4-26-30
Views:
960
Email this article 