LEVEL OF URIC ACID IN BLOOD SERUM OF NEW PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE
https://doi.org/10.21292/2075-1230-2017-95-4-31-36
Abstract
The level of uric acid in blood serum was investigated in 134 new patients suffering from multiple drug resistant pulmonary tuberculosis (78 men and 56 women). The tests were performed by admission to hospital and then repeated in 1, 2, 3, 4, 5, 6, 7 and 8 months of treatment. Prior to chemotherapy the increased uric acid level was observed in 28.2% of men and 37.5% of women. During treatment with pyrazinamide uric acid level increased in this category of patients in 1 month after treatment start and further it went down; however it was above normal during the whole course of treatment. Monitoring of uric acid level in the patients with initially normal rates has shown that the primary increase of uric acid was observed during the whole course of chemotherapy (8 months) and more often during the first 2 months of treatment both in men and women.
About the Authors
R. Yu. Аbdullaev
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of Biochemical Laboratory,
2, Yauzskaya Alleya, Moscow, 107564
O. G. Komissarova
Central Tuberculosis Research Institute;
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Deputy Director for Research and Therapy,
2, Yauzskaya Alleya, Moscow, 107564
E. S. Chumakova
Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Head of the Therapy Department,
56, Dostoevsky St., Stavropol, 355019
V. S. Odinet
Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Chief Doctor,
56, Dostoevsky St., Stavropol, 355019
References
1. Federalnye klinicheskiye rekomendatsii po diagnostike i lecheniyu tuberkuleza organov dykhaniya s mnozhestvennoy lekarstennoy ustoichivostyu vozbuditelya. [Federal clinical recommendations for diagnosis and treatment of respiratory tuberculosis with multiple drug resistance]. May 28, 2015, Moscow, 2015, 63 p. http://roftb.ru/netcat_files/doks2015/rec2.pdf
2. Berry C.E., Hare J.M. Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications. J. Physiol., 2004, vol. 555, (pt. 3), pp. 589-606.
3. Chonchol M., Shlipak M.G., Katz R. et al. Relationship of uric acid with progression of kidney disease. Am. J. Kidney Dis., 2007, vol. 50, pp. 239-247.
4. Feig D.I. Serum uric acid and the risk of hypertension and chronic kidney disease. Curr. Opin. Rheumatol., 2014, vol. 26, no. 2, pp. 176-185.
5. George J., Struthers A.D. Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Vasc. Health Risk Manag., 2009, vol. 5, pp. 265-272.
6. Gerdan G., Nurullah A., Ucan E.S. et al. Paradoxical increase in uric acid level with allopurinol use in pyrazinamideinduced hyperuricemia. Singapore Med. J., 2013, vol. 54, no. 6, pp. 125-128.
7. Gibbs B.F., Gonçalves Silva I., Prokhorov A. et al. Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity. Oncotarget, 2015, vol. 6, no. 30, pp. 28678-28692.
8. Inoue T., Ikeda N., Kurasawa T. et al. Hyperuricemia and arthralgia during pyrazinamide treatment. Nihon Naika Gakkai Zasshi, 1999, vol. 37, pp. 115-118.
9. Khosla U. M., Zharikov S., Finch J.L. et al. Hyperuricemia induces endothelial dysfunction. Kidney Int., 2005, vol. 67, pp. 1739-1742.
10. Levey A.S., Stevens L.A., Schmid C.H. et al. A new equation to estimate glomerular filtration rate. Ann. Intern. Med., 2009, vol. 150, no. 9, pp. 604-612.
11. Louthrenoo W., Hongsongkiat S., Kasitanon N., Wangkaew S., Jatuworapruk K. Effect of antituberculous drugs on serum uric acid and urine uric acid excretion. J. Clin. Rheumatol., 2015, vol. 21, no. 7, pp. 346-348.
12. Postlethwaite A.E., Bartel A.G., Kelley W.N. Hyperuricemia due to ethambutol. N. Engl. J. Med., 1972, vol. 286, pp. 761-762.
13. Sharma T.N., Jain N.K., Mathur B.B. et al. Hyperuricemia and arthralgia during pyrazinamide therapy. Indian J. Tuberc., 1981, vol. 28, pp. 92-96.
14. Solangi G.A., Zuberi B.F., Shaikh S., Shaikh W.M. Pyrazinamide induced hyperuricemia in patients taking anti-tuberculous therapy. J. Coll Physicians Surg. Pak., 2004, vol. 14, no. 3, pp. 136-138.
15. Zhang L., Wang F., Wang X., Liu L., Wang H. The association between plasma uric acid and renal function decline in a Chinese population-based cohort. Nephrol. Dial. Transplant., 2012, vol. 27, no. 5, pp. 1836-1839.
Review
For citations:
Аbdullaev R.Yu., Komissarova O.G., Chumakova E.S., Odinet V.S. LEVEL OF URIC ACID IN BLOOD SERUM OF NEW PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE. Tuberculosis and Lung Diseases. 2017;95(4):31-36. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-4-31-36
Views:
2177
Email this article 