RESULTS OF IMMUNOLOGICAL TESTING OF NEW GENERATION IN CHILDREN UNDER MASSIVE VACCINATION AGAINST TUBERCULOSIS
https://doi.org/10.21292/2075-1230-2017-95-5-46-52
Abstract
Development of new methods of immune diagnostics of tuberculous infection and their introduction into tuberculosis control practice have changed approaches to diagnostics of tuberculosis in Russia. Along with world recognized IGRA-tests the test with tuberculous recombinant allergen (TRA) developed by Russian researchers is also widely used. High diagnostic value of each of the methods is proved by multiple national and international trials however there is no research comparing results of these methods in the diagnostics of tuberculous infection in children, including those with concurrent conditions. During the study data of testing in 654 children in the age from 0 to 14 years old with positive sensitivity to tuberculin as per Mantoux test with 2 TU were analyzed. All patients had modern immunological tests done: TRA and IGRA-tests (QuantifeRON® Gold ELISA (QFT) and T-SPOT.TB). The study confirmed the low value of Mantoux test with 2 TU as a method of early tuberculosis detection in children; it detected underdiagnosis (10-50%) and overdiagnosis (78%) of latent tuberculous infection in the children with different sensitivity level as per data of Mantoux test with 2 TU. Comparing the results of TRA and IGRA tests it is possible to state that they are compatible for 76-81% of cases. The group of children was detected who had allergic and endocrine disorders (obesity), for whom IGRA tests were recommended to exclude chances of false-positive results of TRA tests.
About the Authors
A. A. Starshinova
St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg
Russian Federation
Russian Federation
Doctor of Medical Sciences, Leading Researcher
S. M. Аnaniev
St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg
TB Dispensary no. 5, St. Petersburg
Russian Federation
Russian Federation
Full time Post-Graduate Student, Phthisiologist of TB
Yu. E. Ovchinnikova
St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of Therapy Department for Pulmonary Tuberculosis in Children
N. V. Korneva
TB Dispensary no. 5, St. Petersburg
Russian Federation
Russian Federation
Candidate of Medical Sciences, Phthisiologist
I. F. Dovgalyuk
St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of Children Tuberculosis Unit
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Review
For citations:
Starshinova A.A., Аnaniev S.M., Ovchinnikova Yu.E., Korneva N.V., Dovgalyuk I.F. RESULTS OF IMMUNOLOGICAL TESTING OF NEW GENERATION IN CHILDREN UNDER MASSIVE VACCINATION AGAINST TUBERCULOSIS. Tuberculosis and Lung Diseases. 2017;95(5):46-52. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-5-46-52
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