GENETIC DIVERSITY OF DRUG RESISTANT STRAINS OF MYCOBACTERIUM TUBERCULOSIS IN OMSK REGION
https://doi.org/10.21292/2075-1230-2017-95-7-33-39
Abstract
The article presents the investigation results of the specific epidemic situation on tuberculous infection in Omsk Region in 2006-2015 and molecular genetic features of M. tuberculosis strains with multiple drug resistance circulating in this region. Bacteriological, molecular genetic methods, VNTR-typing were used as well as descriptive techniques of the epidemiological process. Tuberculosis prevalence made 269.2 per 100,000 population. There is an increase in those with bacillary excretion among new cases of respiratory tuberculosis from 39.8% to 53.4%. Drug resistance was detected in 48.0% of new cases. Among drug resistance patterns, MDR made 57%, and extensive drug resistance (XDR) increased from 2.5 to 7.0%. In 2015 prevalence of XDR tuberculosis made 8.9 per 100,000 population in Omsk Region. When performing VNTR-typing of 77 samples of M. tuberculosis DNA with MDR, 27 genetic types were identified. The population of MDR strain of M. tuberculosis is heterogeneous and presented by strains of various genetic families -Beijing, LAM, S,Haarlem,Uganda. The investigation showed that isolates ofBeijing family prevailed (76.6%).
About the Authors
O. A. Pаsechnik
Omsk State Medical University
Russian Federation
Russian Federation
Oksana A. Pasechnik - Candidate of Medical Sciences, Senior Teacher at Epidemiology Department.
9, Mira St., Omsk, 644050 Phone: +7 (3812) 65-06-54.
M. A. Dymovа
Novosibirsk Tuberculosis Research Institute;
Chemical Biology and Fundamental Medicine Institute, Siberian Department of Russian Academy of Sciences
Russian Federation
Russian Federation
Maya A. Dymova - Chemical Biology and Fundamental Medicine Institute, Siberian Department of Russian Academy of Sciences, Candidate of Biological Sciences, Junior Researcher of Pharmacogenomics Laboratory
8, Akad. Lavrentieva Ave., Novosibirsk, 630090 Phone: +7 (3833) 63-51-71.
V. L. Stаsenko
Omsk State Medical University
Russian Federation
Russian Federation
Vladimir L. Stasenko - Doctor of Medical Sciences, Professor, Head of Epidemiology Department.
9, Mira St., Omsk, 644050 Phone: +7 (3812) 65-06-54.
M. P. Tаtаrintsevа
Clinical TB Dispensary
Russian Federation
Russian Federation
Marina P. Tatarintseva - Chief Doctor.
2, Tselinnaya St., Omsk, 644058
I. P. Kolesnikovа
Clinical TB Dispensary
Russian Federation
Russian Federation
Lyubov P. Kolesnikova - Head of Bacteriological Laboratory.
2, Tselinnaya St., Omsk, 644058
E. S. Lyapinа
Clinical TB Dispensary
Russian Federation
Russian Federation
Elena S. Lyapina - Bacteriologist
2, Tselinnaya St., Omsk, 644058
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Review
For citations:
Pаsechnik O.A., Dymovа M.A., Stаsenko V.L., Tаtаrintsevа M.P., Kolesnikovа I.P., Lyapinа E.S. GENETIC DIVERSITY OF DRUG RESISTANT STRAINS OF MYCOBACTERIUM TUBERCULOSIS IN OMSK REGION. Tuberculosis and Lung Diseases. 2017;95(7):33-39. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-7-33-39
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