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SIMULATION OF EPIDEMIC TRANSMISSION OF МYCOBACTERIUM TUBERCULOSIS IN THE SAKHA REPUBLIC (YUKUTIA )

https://doi.org/10.21292/2075-1230-2017-95-7-40-47

Abstract

Goal: reconstruction of epidemic transmission of Beijing genotype of Mycobacterium tuberculosis on the territory with limited migration based on the comparative study of 153 isolates isolated from patients of different generations in theSakhaRepublic (Yakutia).

Materials and methods. The structure of Mycobacterium tuberculosis population was described and analyzed through MIRU-VNTR-genotyping, subtyping of the parts of RD105/RD207 genome, pattern classification as per clonal pattern of Merker M. et al (2015), and phylogenetic simulation.

Results. It was found out that highly transmissive subtypes of Beijing genotype having a high potential of developing drug resistance was confidently more prevalent (χ2 = 8.3, p < 0.01) among younger people (born after 1990) compared to the older generation (born before 1959). It was also found out that during previous five decades a certain shift occurred in the structure of M. tuberculosis population.

Conclusion. The obtained data confirm the hypothesis that epidemic sybtypes ofBeijing genotype were brought to the territory of theSakhaRepublic (Yakutia) fairly recently (approximately fifty years ago) compared to the other regions ofRussia.

About the Authors

S. N. Zhdаnovа
Research Center of Family Health and Reproduction Problems
Russian Federation

Svetlana N. Zhdanova - Candidate of Medical Sciences, Senior Researcher. 

3, Karla Marksa St., Irkutsk, 664003. Phone: +7 (3952) 33-34-25.





O. B. Ogаrkov
Research Center of Family Health and Reproduction Problems
Russian Federation

Oleg B. Ogarkov - Doctor of Medical Sciences, Head of Epidemiology and Microbiology Department. 

3, Karla Marksa St., Irkutsk, 664003. Phone: +7 (3952) 33-34-25.




M. K. Vinokurovа
Scientific Practical Phthisiology Center
Russian Federation

Maria K. Vinokurova - Doctor of Medical Sciences, Deputy Director

93, P. Alekseev St., Yakutsk, Sakha Republic (Yakutia), 677000. Phone: +7 (411) 239-03-30. 



G. I. Аlekseevа
Scientific Practical Phthisiology Center
Russian Federation

Galina I. Alekseeva - Doctor of Medical Sciences, Head of Bacteriological Laboratory

93, P. Alekseev St., Yakutsk, Sakha Republic (Yakutia), 677000. Phone: +7 (411) 239-03-30. 



A. F. Krаvchenko
Scientific Practical Phthisiology Center
Russian Federation

Aleksandr F. Kravchenko - Doctor of Medical Sciences, Chief Doctor

93, P. Alekseev St., Yakutsk, Sakha Republic (Yakutia), 677000. Phone: +7 (411) 239-03-30. 



E. D. Sаvilov
Research Center of Family Health and Reproduction Problems; Irkutsk State Medical Academy for Postgraduate Training
Russian Federation

Evgeny D. Savilov, Doctor of Medical Sciences, Professor, Senior Researcher, Head of Epidemiology and Microbiology Department. 

Apt. 4, 100, Yubileyny R.D., Irkutsk, 664049 Phone: +7 (3952) 33-34-25. 



References

1. Zhdanova S.N., Аlekseeva G.I., Ogarkov O.B., Kravchenko А.F., Zorkaltseva E. Yu., Vinokurova M.K., Savilov E.D. Comparative analysis of Mycobacterium tuberculosis genotypes in the Sakha Republic (Yukutia) and Irkutsk Region. Yakutsky Meditsinsky Journal, 2013, no. 1, pp. 68-71. (In Russ.)

2. Zhdanova S.N., Ogarkov O.B., Stepanenko L.А., Lats А.А., Sinkov V.V., Untanova L.S., Аlekseeva G.I., Savilov E.D. Use of RD105 deletion analysis for detection of Beijing genotype of Mycobacterium tuberculosis. Byulleten' Vostochno-Sibirskogo Nauchnogo Tsentra Sibirskogo Otdeleniya Rossiyskoy Akademii Meditsinskikh Nauk, 2011, no. 2, pp. 194-197. (In Russ.)

3. Sivtseva S.I. Population of Yukutia after the war: living conditions. Vestnik of SVFU, 2013, vol. 10, pp. 69-74. (In Russ.)

4. Sinkov V.V., Savilov E.D., Ogarkov O.B. Reconstruction of epidemic history of Beijing genotype of Mycobacterium tuberculosis in Russia and countries of the former Soviet Union basing on spoligotyping results, Mol. Genet. Microbiol. Virusol., 2011, no. 3, pp. 25-29. (In Russ.)

5. Sinkov V.V., Savilov E.D., Ogarkov O.B. Epidemiology of tuberculosis in Russia: epidemiological and historical evidences of Beijing genotype of M. tuberculosis transmission in the XXth cent. Tuberculosis and Lung Diseases, 2012, no. 3, pp. 057-062. (In Russ.)

6. Sukneva S.A. Migration in the Sakha Republic (Yakutia). Prostranstvennaya Ekonomika, 2008, no. 1, pp. 62-67. (In Russ.)

7. Dabernat H., Theves C., Bouakaze C., Nikolaeva D., Keyser C., Mokrousov I., Geraut A., Duchesne S., Gerard P., Alexeev A. N., Crubezy E., Ludes B. Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century. PLoS ONE, 2014, vol. 9, no. 2: e89877. doi:10.1371/journal.pone.0089877.

8. Groenheit R., Ghebremichael S., Pennhag A., Jonsson J., Hoffner S., Couvin D., Koivula T., Rastogi N., Kallenius G. Mycobacterium tuberculosis strains potentially involved in the TB epidemic in Sweden a century ago. PLoS ONE, 2012, vol. 77, no. 10:e46848. DOI: 10.1371/journal.pone.0046848.

9. Marais B.J., Gie R.P., Schaaf H.S., Hesseling A.C., Obihara C.C., Starke J.J., Enarson D.A., Donald P.R., Beyers N. The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. Int. J. Tuberc. Lung Dis., 2004, vol. 8, no. 4, pp. 392-402.

10. Merker M., Blin C., Mona S., Duforet-Frebourg N., Lecher S., Willery E., Blum M.G., Rusch-Gerdes S., Mokrousov I., Aleksic E. et al. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage. Nat. Genet., 2015, vol. 47, no. 3, pp. 242-249.

11. MIRU. URL: http://www.miru-vntrplus.org/MIRU/miruinfo.faces;jsessionid=89112F274226E781C7B0B0D9118FDD70

12. Mokrousov I. Insights into the origin, emergence, and current spread of a successful Russian clone of Mycobacterium tuberculosis. Clin. Microbiol. Rev., 2013, vol. 26, no. 2, pp. 342-360.

13. Mokrousov I., Ly H. M., Otten T., Lan N. N., Vyshnevskyi B., Hoffner S., Narvskaya O. Origin and primary dispersal of the Mycobacterium tuberculosis Beijing genotype: clues from human phylogeography. Genome Res., 2005, vol. 15, no. 10, pp. 1357-1364.

14. Morariu V.I., Srinivasan B.V., Raykar V.C., Duraiswami R., Davis L. Automatic online tuning for fast Gaussian summation. Advances in Neural Information Processing Systems, 2008, vol. 21, pp. 1113-1120.

15. Ogarkov O., Mokrousov I., Sinkov V., Zhdanova S., Antipina S., Savilov E. «Lethal» combination of Mycobacterium tuberculosis Beijing genotype and human CD209 -336G allele in Russian male population. Infect. Genet. Evol., 2012, vol. 12, no. 4, pp. 732-736.

16. Okonechnikov K., Golosova O., Fursov M. The UGENE team. Unipro UGENE: a unified bioinformatics toolkit. Bioinformatics, 2012, vol. 28, pp. 1166-1167.

17. SITVIT. URL: http://www.pasteur-guadeloupe.fr:8081/SITVIT_ONLINE/query

18. Smit P.W., Haanpera M., Rantala P., Couvin D., Lyytikainen O., Rastogi N., Ruutu P., Soini H. Genotypic characterization and historical perspective of Mycobacterium tuberculosis among older and younger Finns, 2008-2011. Clin. Microbiol. Infect., 2014, vol. 20, no. 11, pp. 1134-1139.

19. Supply P., Allix C., Lesjean S., Cardoso-Oelemann M., Rusch-Gerdes S., Willery E., Savine E., de Haas P., van Deutekom H., Roring S. et al. Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis. J. Clin. Microbiol., 2006, vol. 44, no. 12, pp. 4498-4510.

20. Zhdanova S., Heysell S., Ogarkov O., Boyarinova G., Alexeeva G., Pholwat S., Zorkaltseva E., Houpt E., Savilov E. Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation. Emerging Infectious Diseases, 2013, vol. 19, no. 10, pp. 1649-1652.


Review

For citations:


Zhdаnovа S.N., Ogаrkov O.B., Vinokurovа M.K., Аlekseevа G.I., Krаvchenko A.F., Sаvilov E.D. SIMULATION OF EPIDEMIC TRANSMISSION OF МYCOBACTERIUM TUBERCULOSIS IN THE SAKHA REPUBLIC (YUKUTIA ). Tuberculosis and Lung Diseases. 2017;95(7):40-47. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-7-40-47

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)