SIMULATION OF EPIDEMIC TRANSMISSION OF МYCOBACTERIUM TUBERCULOSIS IN THE SAKHA REPUBLIC (YUKUTIA )
https://doi.org/10.21292/2075-1230-2017-95-7-40-47
Abstract
Goal: reconstruction of epidemic transmission of Beijing genotype of Mycobacterium tuberculosis on the territory with limited migration based on the comparative study of 153 isolates isolated from patients of different generations in theSakhaRepublic (Yakutia).
Materials and methods. The structure of Mycobacterium tuberculosis population was described and analyzed through MIRU-VNTR-genotyping, subtyping of the parts of RD105/RD207 genome, pattern classification as per clonal pattern of Merker M. et al (2015), and phylogenetic simulation.
Results. It was found out that highly transmissive subtypes of Beijing genotype having a high potential of developing drug resistance was confidently more prevalent (χ2 = 8.3, p < 0.01) among younger people (born after 1990) compared to the older generation (born before 1959). It was also found out that during previous five decades a certain shift occurred in the structure of M. tuberculosis population.
Conclusion. The obtained data confirm the hypothesis that epidemic sybtypes ofBeijing genotype were brought to the territory of theSakhaRepublic (Yakutia) fairly recently (approximately fifty years ago) compared to the other regions ofRussia.
About the Authors
S. N. Zhdаnovа
Research Center of Family Health and Reproduction Problems
Russian Federation
Russian Federation
Svetlana N. Zhdanova - Candidate of Medical Sciences, Senior Researcher.
3, Karla Marksa St., Irkutsk, 664003. Phone: +7 (3952) 33-34-25.
O. B. Ogаrkov
Research Center of Family Health and Reproduction Problems
Russian Federation
Russian Federation
Oleg B. Ogarkov - Doctor of Medical Sciences, Head of Epidemiology and Microbiology Department.
3, Karla Marksa St., Irkutsk, 664003. Phone: +7 (3952) 33-34-25.
M. K. Vinokurovа
Scientific Practical Phthisiology Center
Russian Federation
Russian Federation
Maria K. Vinokurova - Doctor of Medical Sciences, Deputy Director.
93, P. Alekseev St., Yakutsk, Sakha Republic (Yakutia), 677000. Phone: +7 (411) 239-03-30.
G. I. Аlekseevа
Scientific Practical Phthisiology Center
Russian Federation
Russian Federation
Galina I. Alekseeva - Doctor of Medical Sciences, Head of Bacteriological Laboratory.
93, P. Alekseev St., Yakutsk, Sakha Republic (Yakutia), 677000. Phone: +7 (411) 239-03-30.
A. F. Krаvchenko
Scientific Practical Phthisiology Center
Russian Federation
Russian Federation
Aleksandr F. Kravchenko - Doctor of Medical Sciences, Chief Doctor.
93, P. Alekseev St., Yakutsk, Sakha Republic (Yakutia), 677000. Phone: +7 (411) 239-03-30.
E. D. Sаvilov
Research Center of Family Health and Reproduction Problems;
Irkutsk State Medical Academy for Postgraduate Training
Russian Federation
Russian Federation
Evgeny D. Savilov, Doctor of Medical Sciences, Professor, Senior Researcher, Head of Epidemiology and Microbiology Department.
Apt. 4, 100, Yubileyny R.D., Irkutsk, 664049 Phone: +7 (3952) 33-34-25.
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For citations:
Zhdаnovа S.N., Ogаrkov O.B., Vinokurovа M.K., Аlekseevа G.I., Krаvchenko A.F., Sаvilov E.D. SIMULATION OF EPIDEMIC TRANSMISSION OF МYCOBACTERIUM TUBERCULOSIS IN THE SAKHA REPUBLIC (YUKUTIA ). Tuberculosis and Lung Diseases. 2017;95(7):40-47. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-7-40-47
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