THE STATE OF BRONCHIAL CILIATED EPITHELIUM AND MUCOCILIARY TRANSPORT IN CASE OF CHRONIC BRONCHITIS AND CONCURRENT LONG TERM SMOKING
https://doi.org/10.21292/2075-1230-2018-96-12-43-48
Abstract
The objective of the study: to compare the state of mucociliary clearance and bronchial ciliated epithelium in smokers and non-smokers suffering from chronic bronchitis.
Subjects and methods. 80 chronic bronchitis patients with exacerbation were examined; they were divided into 2 groups: Group 1 included 40 active smokers and Group 2 comprised of 40 patients who had never smoked. The comparison group included 10 non-smokers with no respiratory disorders. All chronic bronchitis patients had certain examinations including bronchoscopy with biopsy and consequent ultrastructural tests of biopsy specimens and aerosol scintigraphy of the lungs for mucociliary clearance assessment.
Results. Morphological and functional changes in the mucociliary transport system were detected in case of chronic bronchitis versus those healthy. Those changes were more profound in the smokers compared to non-smokers. Thus, the smokers with chronic bronchitis were diagnosed with a significant reduction of mucociliary clearance corresponding to degree II of mucociliary transport system failure, which was down to 16.60 ± 2.40% (down to 23.91 ± 2,11% in non-smokers, while it was 34.82 ± 2.14% in health) with concurrent diffuse bilateral bronchitis deformans and significant amount of very viscous mucosal or mucopurulent discharge according to the endoscopy data. The ultrastructural testing of biopsy specimens detected the significant damage of bronchial ciliated epithelium in the form of diffuse atrophy, focal metaplasia, which was one of the obvious causes of significant impairment of mucociliary transport.
About the Authors
N. E. Chernekhovskaya
Russian Medical Academy of On-Going Professional Education
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor of Endoscopy Department
5, 2nd Botkinsky Rd., Moscow, 125284
N. Yu. Vyrenkova
Russian Medical Academy of On-Going Professional Education
Russian Federation
Russian Federation
Candidate of Medical Sciences
5, 2nd Botkinsky Rd., Moscow, 125284
I. M. Maltseva
Russian Medical Academy of On-Going Professional Education
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of Endoscopy Department
5, 2nd Botkinsky Rd., Moscow, 125284
A. V. Volova
Russian Medical Academy of On-Going Professional Education
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of Endoscopy Department
5, 2nd Botkinsky Rd., Moscow, 125284
A. V. Povalyaev
Russian Medical Academy of On-Going Professional Education
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of Endoscopy Department
5, 2nd Botkinsky Rd., Moscow, 125284
N. V. Vychuzhanina
Russian Medical Academy of On-Going Professional Education
Russian Federation
Russian Federation
Candidate of Medical Sciences, Assistant of Endoscopy Department
5, 2nd Botkinsky Rd., Moscow, 125284
References
1. Gering E.А., Sukhodolo I.V., Pleshko R.I. Specific features of bronchial mucosal membrane in the smokers with chronic obstructive pulmonary disease. Pulmonoloiya, 2015, vol. 25, no. 3, pp. 357-362. (In Russ.)
2. Kobyakova O.S., Kulikov E.S., Deev I.А. Smoking as a risk factor of chronic non-infectious diseases as per the data obtained through the analysis of activities of the health centers of Tomsk. Profilakticheskaya Meditsina, 2015, vol. 18, no. 1, pp. 21-24. (In Russ.)
3. Krishtafovich А.А., Аriel B.M. Simulation of tobacco smoking and deposition of microparticles of smoke and resins in the respiratory tract. Pulmonoloiya, 2017, vol. 27, no. 5, pp. 643-649. (In Russ.)
4. Lyubavina N.А., Makarova E.V., Menkov N.M. A specific clinical course of chronic obstructive pulmonary disease depending on smoking history and state of the host immunity. Pulmonoloiya, 2013, vol. 23, no. 4, pp. 52-55. (In Russ.)
5. Nikitin V.А., Starodubtsev I.А., Vasilieva L.V. A number of anatomic risk factors providing the impact on COPD progression. Ter. Arkhiv, 2018, no. 1, pp. 27-29. (In Russ.)
6. Postnikova L.B., Dorovskoy I.А., Kostrov V.А. Epidemiological characteristics of tobacco smoking and comparative assessment of the state of respiratory system in male smokers. Pulmonoloiya, 2016, vol. 26, no. 1, pp. 52-58. (In Russ.)
7. Pulmonologiya. Natsionalnoye rukovodstvo. Kratkoye Izdaniye. [Pulmonology. National Guidelines at a glance]. A.G. Chuchalin, eds., Moscow, GEOTAR-Media Publ., 2013, 767 p.
8. Pespiratornaya meditsina. Rukovodstvo. [Respiratory medicine. Guidelines]. Second edition, reviewed and supplemented. A.G. Chuchalin, eds., Moscow, Litterra Publ., 2017, Vv. 1-3.
9. Sakharova G.M., Аntonov N.S., Semagay O.O. The global assessment of tobacco-smoking among young people at the age of 13-15 years old in RF: comparison with the trends in 2004 and 2015. Pulmonoloiya, 2017, vol. 27, no. 2, pp. 179-186. (In Russ.)
10. Struchkov B.V., Borisova O.E., Ivanushkina А.V. On the value of capnometric tests when examining smokers and those with initial signs of chronic obstructive pulmonary disease. Pulmonoloiya, 2015, vol. 25, no. 2, pp. 167-174. (In Russ.)
11. Fokina N.А., Аntonov N.S., Sakharova G.M. Current aspects of respiratory health assessment in young smokers with the use of acoustic analysis. Pulmonoloiya, 2016, vol. 26, no. 1, pp. 59-63. (In Russ.)
12. Chernekhovskaya N.E., Fedchenko G.G., Аndreev V.G., Povalyaev А.V. Rentgenografiya i endoskopiya organov dykhaniya. [X-ray and endoscopy examination of respiratory organs]. Moscow, BINOM Publ., 2017, 253 p.
Review
For citations:
Chernekhovskaya N.E., Vyrenkova N.Yu., Maltseva I.M., Volova A.V., Povalyaev A.V., Vychuzhanina N.V. THE STATE OF BRONCHIAL CILIATED EPITHELIUM AND MUCOCILIARY TRANSPORT IN CASE OF CHRONIC BRONCHITIS AND CONCURRENT LONG TERM SMOKING. Tuberculosis and Lung Diseases. 2018;96(12):43-48. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-12-43-48
Views:
1715
Email this article 