THE MORPHOLOGICAL PATTERN OF BRONCHIAL WALL AT THE PLACE OF RESECTION IN PULMONARY TUBERCULOSIS PATIENTS AFTER PERIBRONCHIAL LYMPHOTROPIC OR INHALATION THERAPY
https://doi.org/10.21292/2075-1230-2018-96-12-49-54
Abstract
Surgical specimens collected from 13 cases of destructive pulmonary tuberculosis were retrospectively analyzed; for at least 3 months in the pre-operative period, all of them received peribronchial lymphotropic therapy or inhalations with anti-tuberculosis drugs due to inflammatory changes in the bronchi. All patients underwent lung resection on the level of the main or lobar bronchus. During inhalations with anti-tuberculosis drugs, the pathomorphological tests showed profound dystrophy of ciliated epithelium of bronchial mucosal membrane and significant thickening of basement membrane. While in the group treated with peribronchial lymphotropic therapy such changes were minimal or absent at all (p < 0.001). It was concluded that peribronchial lymphotropic therapy was a modern highly effective treatment method within comprehensive preparation for surgery in destructive pulmonary tuberculosis patients with multiple or extensive drug resistance and endobronchitis as a complication.
About the Authors
K. A. Аvdienko
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Thoracic Surgeon
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-76-93
V. A. Krasnov
Novosibirsk Tuberculosis Research Institute
Novosibirsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Director.
Phone/Fax: +7 (383) 203-78-25
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-76-93
D. V. Krasnov
Novosibirsk Tuberculosis Research Institute
Novosibirsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of Tuberculosis Pulmonary Surgery Department
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-76-93
N. G. Grischenko
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical Sciences, Thoracic Surgeon
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-76-93
M. V. Reykhrud
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Thoracic Surgeon
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-76-93
V. G. Kononenko
Novosibirsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor of Phthisiopulmonology Department, Morbid Anatomist.
52, Krasny Ave., Novosibirsk, 630091
Phone: +7 (383) 343-65-12.
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Review
For citations:
Аvdienko K.A., Krasnov V.A., Krasnov D.V., Grischenko N.G., Reykhrud M.V., Kononenko V.G. THE MORPHOLOGICAL PATTERN OF BRONCHIAL WALL AT THE PLACE OF RESECTION IN PULMONARY TUBERCULOSIS PATIENTS AFTER PERIBRONCHIAL LYMPHOTROPIC OR INHALATION THERAPY. Tuberculosis and Lung Diseases. 2018;96(12):49-54. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-12-49-54
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