Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients
https://doi.org/10.21292/2075-1230-2019-97-7-11-17
Abstract
The objective of the study: to investigate the spectrum of drug resistance and genotypes of Mycobacterium tuberculosis isolated from lung surgical specimens of tuberculosis patients.
Subjects and methods. Bacteriological testing of surgical specimens of 287 patients operated due to tuberculosis was performed. Molecular genetic tests detected Mycobacterium tuberculosis with multiple drug resistance in 66.7% of patients. Test results of 42 samples were compared with culture results and a high level of coincidence was observed for isoniazid (90.9%), rifampicin (89.3%) and fluoroquinolones (81.2%). It was found out that the majority of samples (80.8%) belonged to Beijing family.
About the Authors
K. V. Belousovа
Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Ksenia V. Belousova - Candidate of Biological Sciences, Senior Researcher.
50, XXII Parts"ezda St., Yekaterinburg, 620039, Phone: +7 (343) 333-44-66
T. V. Umpelevа
Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Tatiana V. Umpeleva - Candidate of Biological Sciences, Senior Researcher.
50, XXII Parts"ezda St., Yekaterinburg, 620039, Phone: +7 (343) 333-44-66
N. I. Eremeevа
Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Natalya I. Eremeeva - Candidate of Biological Sciences, Senior Researcher, Head of Department for Microbiology and PCR Diagnostics.
50, XXII Parts"ezda St., Yekaterinburg, 620039, Phone: +7 (343) 333-44-66
L. A. Golubevа
Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Lyudmila A. Golubeva - Junior Researcher, Bacteriologist.
50, XXII Parts"ezda St., Yekaterinburg, 620039, Phone: +7 (343) 333-44-66
T. Yu. Botevа
Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Tatiana Yu. Boteva - Bacteriologist.
50, XXII Parts"ezda St., Yekaterinburg, 620039, Phone: +7 (343) 333-44-66
D. V. Vаkhrushevа
Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Diana V. Vakhrusheva - Candidate of Biological Sciences, Head of Laboratory for Diagnostic and Experimental Testing Techniques.
50, XXII Parts"ezda St., Yekaterinburg, 620039, Phone: +7 (343) 333-44-66
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Review
For citations:
Belousovа K.V., Umpelevа T.V., Eremeevа N.I., Golubevа L.A., Botevа T.Yu., Vаkhrushevа D.V. Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients. Tuberculosis and Lung Diseases. 2019;97(7):11-17. (In Russ.) https://doi.org/10.21292/2075-1230-2019-97-7-11-17
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