The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea
https://doi.org/10.21292/2075-1230-2020-98-4-24-31
Abstract
The objective: to study the effect of sleep-related breathing disorders on the activation of blood coagulation reactions associated with systemic inflammation in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea.
Subjects and methods. An open prospective comparative study analyzed thrombogenic risk factors, markers of inflammation and insulin resistance in 65 patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea, 26 of them received non-invasive ventilation as a part of their therapy (main group).
Results. The blood levels of homocysteine and prothrombin fragments 1+2 are closely associated with the duration of nocturnal hypoxemia, concentrations of C-reactive protein, C-peptide, and endothelial vascular growth factor and can be managed with CPAP therapy.
The authors state that they have no conflict of interests.
About the Authors
I. Ya. Tseymakh
Altai State Medical University
Russian Federation
Irina Ya. Tseymakh Senior Researcher of Pulmonology and Surgery Laboratory
Russian Federation
Irina Ya. Tseymakh Senior Researcher of Pulmonology and Surgery Laboratory
Ya. N. Shoykhet
Altai State Medical University
Russian Federation
Russian Federation
Yakov N. Shoykhet Head of Intermediate Level Surgery and Hospital Surgery Department named after I.I. Neymark with Surgery Training Course.
Phone: +7 (385) 268-50-23
A. E. Tseymakh
Altai State Medical University
Russian Federation
Russian Federation
Aleksandr E. Tseymakh Postgraduate Student of Oncology, Radiation Therapy and X-ray Diagnostics Department with Professional Development Training.
Phone: +7 (385) 268-43-96
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For citations:
Tseymakh I.Ya., Shoykhet Ya.N., Tseymakh A.E. The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea. Tuberculosis and Lung Diseases. 2020;98(4):24-31. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-4-24-31
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