Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process
https://doi.org/10.21292/2075-1230-2020-98-8-7-13
Abstract
The objective of the study is to assess the effect of rs6707530 polymorphism of the FN1 gene and rs1150754 polymorphism of the TNXB gene on the healing of lung tissue destruction in patients with newly detected pulmonary tuberculosis.
Subjects and methods. 82 patients older 18 years with newly diagnosed pulmonary tuberculosis with destruction were enrolled in the study. X-ray data were assessed on the 2nd, 4th and 6th months of the study. Patients were divided into 2 groups depending on the efficacy of chemotherapy intensive phase.
Results. In the group of patients with an effective course of chemotherapy, the frequency of carriers of G allele (p < 0.001) and T/G genotype (p = 0.01) in rs6707530 locus of the FN1 gene was higher. While T/T genotype (p = 0.002) and T allele (p < 0.001) prevailed among the patients with persisting destruction of lung tissue after the intensive phase of chemotherapy.
About the Authors
K. Yu. Samsonov
Omsk State Medical University
Russian Federation
Russian Federation
Kirill Yu. Samsonov, Full-time Postgraduate Student of Department of Phthisiology, Phthisiosurgery and infectious Diseases
12, Lenina St., Omsk, 644099
Phone: +7 (3812) 95-68-24.
A. V. Mordyk
Omsk State Medical University
Russian Federation
Russian Federation
Anna V. Mordyk, Doctor of Medical Sciences, Professor, Head of Phthisiology, Phthisiosurgery and Infectious Diseases Department
12, Lenina St., Omsk, 644099
Phone: +7 (3812) 95-68-24.
A. R. Аroyan
Clinical TB Dispensary
Russian Federation
Russian Federation
Anna R. Аroyan, Head of Pulmonary Tuberculosis Department no. 1
2, Tselinnaya St., Omsk, Omsk Region, 644058
Phone: +7 (3812) 42-22-15
T. L. Batischeva
Clinical TB Dispensary
Russian Federation
Russian Federation
Tatiana L. Batischeva, Candidate of Medical Sciences, Deputy Chief Physician for Medical Activities
2, Tselinnaya St., Omsk, Omsk Region, 644058
Phone: +7 (3812) 42-22-15
O. G. Ivanova
Omsk State Medical University
Russian Federation
Russian Federation
Olga G. Ivanova, Candidate of Medical Sciences, Associate Professor of Phthisiology, Phthisiosurgery and Infectious Diseases Department
12, Lenina St., Omsk, 644099
Phone: +7 (3812) 95-68-24
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Review
For citations:
Samsonov K.Yu., Mordyk A.V., Аroyan A.R., Batischeva T.L., Ivanova O.G. Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process. Tuberculosis and Lung Diseases. 2020;98(8):7-13. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-8-7-13
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