Community-acquired pneumonia in HIV patients
https://doi.org/10.21292/2075-1230-2021-99-4-22-28
Abstract
The objective: to study the frequency and nature of community-acquired pneumonia (CAP) in HIV patients.
Subjects and methods: The continuous longitudinal retrospective study of all cases of respiratory diseases among HIV patients (n = 185), who received in-patient treatment in the therapy department.
Results. CAP was diagnosed in 38.4% (n = 71) of patients and it was the most frequent respiratory disease among HIV patients. The median CD4 count in CAP made 197.5 cells/μL, 9.1% of patients received antiretroviral therapy before hospital admission. 74.7% of CAP patients (n = 53) had lesions disseminated to several lobes. Laboratory parameters revealed in severe CAP (leukocytosis > 12 × 109/L, leukopenia < 4.0 × 109/L and thrombocytopenia < 100 × 1012/L) were associated with the degree of immunodeficiency and did not depend on the infiltration dissemination (p > 0.05). Bacteremia in CAP was detected in 20.8% of patients and it was associated with the failure of standard empiric antibiotic therapy (p < 0.05). 9.9% of CAP patients (n = 7) were diagnosed with polymicrobial infection. Lethal outcomes of CAP were recorded in 5.6% of cases (n = 4), all with severe immunosuppression (the median of CD4 count was 5 cells/μL), 2 cases had bilateral subtotal CAP and 2 suffered from polymicrobial infection.
About the Authors
I. B. Viktorova
Novokuznetsk State Institute for Doctors' Professional Development – Branch of Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Irina B. Viktorova – Candidate of Medical Sciences, Associate Professor of Phthisiopulmonology Department
5, Stroiteley Ave., Novokuznetsk, 654005.
V. N. Zimina
Peoples’ Friendship University of Russia;
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Vera N. Zimina – Peoples’ Friendship University of Russia, Doctor of Medical Sciences, Professor of the Infectious Diseases Department with Training Courses in Epidemiology and Phthisiology of the Medical Institute
6, Miklukho-Maklaya St., Moscow, 117198
I. V. Dadyka
Novokuznetsk Branch of Kemerovo Regional Clinical Cardiology Dispensary Named after Academician L. S. Barbarash
Russian Federation
Russian Federation
Inna V. Dadyka – Candidate of Medical Sciences, Head of Therapy Department
35, Kuznetsova St., Novokuznetsk, 654005
I. V. Аndreeva
Novokuznetsk Branch of Kemerovo Regional Clinical Cardiology Dispensary Named after Academician L. S. Barbarash
Russian Federation
Russian Federation
Irina V. Andreeva – General Practitioner
35, Kuznetsova St., Novokuznetsk, 654005
I. A. Golovina
Novokuznetsk Branch of Kemerovo Regional Clinical Cardiology Dispensary Named after Academician L. S. Barbarash
Russian Federation
Russian Federation
Irina A. Golovina – General Practitioner
35, Kuznetsova St., Novokuznetsk, 654005
E. P. Chuzhikova
Novokuznetsk Branch of Kemerovo Regional Clinical Cardiology Dispensary Named after Academician L. S. Barbarash
Russian Federation
Russian Federation
Elena P. Chuzhikova – General Practitioner
35, Kuznetsova St., Novokuznetsk, 654005
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Review
For citations:
Viktorova I.B., Zimina V.N., Dadyka I.V., Аndreeva I.V., Golovina I.A., Chuzhikova E.P. Community-acquired pneumonia in HIV patients. Tuberculosis and Lung Diseases. 2021;99(4):22-28. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-4-22-28
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