Study of elution characteristics of anti-tuberculosis drugs mixed with bone cement
https://doi.org/10.21292/2075-1230-2021-99-4-30-35
Abstract
The objective: to assess the elution characteristics of anti-tuberculosis drugs (isoniazid, cycloserine, rifampicin, amikacin, kanamycin, ethambutol) placed into bone cement samples and put in a liquid medium to determine the possibility of using such systems as a drug reservoir.
Subjects and methods. For in vitro studies, pure substances of the drugs were used. The spectrophotometry was used to study the elution kinetics of the drugs. Absorption spectra of the drugs in the visible and ultraviolet regions were analyzed to reveal the absorption maxima, and the resistance of the chemical structure of the drugs to heating was assessed. Further, the changes of drug release from hardened bone cement samples under static conditions were studied.
Results. It has been found that studied drugs demonstrated satisfactory parameters of thermal stability and elution which makes it possible to use them in a mixture with bone cement.
About the Authors
E. O. Peretsmanas
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Evgeniy O. Peretsmanas – Head of Extrapulmonary Tuberculosis Research Department
Build. 2, 4, Dostoevskiy St., Moscow, 127473
A. A. Аrtyukhov
Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
Aleksandr A. Artyukhov – Professor of Biomaterials Department
9, Miusskaya St., Moscow, 125047
M. I. Shtilman
Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
Mikhail I. Shtilman – Professor of Biomaterials Department
9, Miusskaya St., Moscow, 125047
I. V. Esin
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Igor V. Esin – Senior Researcher of Extrapulmonary Tuberculosis Research Department
Build. 2, 4, Dostoevskiy St., Moscow, 127473
V. S. Zubikov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Vladimir S. Zubikov – Leading Researcher of Extrapulmonary Tuberculosis
Research Department
Build. 2, 4, Dostoevskiy St., Moscow, 127473
I. A. Gerasimov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Ilya A. Gerasimov – Traumatologist and Orthopedist of Extrapulmonary Tuberculosis Unit Department
Build. 2, 4, Dostoevskiy St., Moscow, 127473
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Review
For citations:
Peretsmanas E.O., Аrtyukhov A.A., Shtilman M.I., Esin I.V., Zubikov V.S., Gerasimov I.A. Study of elution characteristics of anti-tuberculosis drugs mixed with bone cement. Tuberculosis and Lung Diseases. 2021;99(4):30-35. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-4-30-35
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