Tuberculosis treatment outcomes in children
https://doi.org/10.21292/2075-1230-2021-99-10-7-13
Abstract
The objective of the study: to assess tuberculosis treatment outcomes in children of 0-14 years old following up changes over the time Subjects and Methods: A retrospective cohort analysis of tuberculosis outcomes in 15,794 children of 0-14 years old was performed, those children were registered for treatment from 2011 to 2018.
Results. The percentage of children switched to MDR regimens increased from 1.3% to 12.0%. The rate of successful treatment of new TB cases in children varied from 93.2% to 96.6% in different years. In children registered for treatment in 2016-2018, 95.7% of new cases with negative or undocumented sputum smear microscopy, 87.8% with positive sputum smear microscopy, and only 83.3% of children with TB relapse were successfully treated. From 2015 to 2018, the percentage of children with treatment failures increased from 0.6% to 1.5%.
Conclusion. Compared to other countries, Russia has a high rate of successful treatment in children with tuberculosis which may be due to their active detection. Nevertheless, there are certain defects in drug susceptibility testing of index cases. Treatment outcomes for children registered in 2020 are expected to be less favorable because of later detection due to the COVID-19 pandemic. The spread of HIV infection among children as well poses a threat of increased mortality in children ill with tuberculosis. To reduce the level of unfavorable outcomes, it is necessary to consider the treatment of children at the age of 0-14 years old ill with tuberculosis in federal centers.
About the Authors
V. A. Аksenova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Valentina A. Аksenova, Doctor of Medical Sciences, Professor, Head of Children and Adolescents Tuberculosis Department
Build. 2, 4, Dostoevskiy St., Moscow, 127473
SPIN-код: 2776-5450
L. I. Rusakova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Larisa I. Rusakova, Doctor of Medical Sciences, Head of Research and Organizational Department
2, Yauzskaya Alleya, Moscow, 107564, phone: +7 (499) 785-91-78
SPIN-код: 7804-6468
S. A. Sterlikov
Central Research Institute for Health Organization and Informatics
Russian Federation
Russian Federation
Sergey A. Sterlikov, Doctor of Medical Sciences, Deputy Head for Program Monitoring of Federal Monitoring Center for Prevention of Tuberculosis Transmission in the Russian Federation
11, Dobrolyubova St., Moscow, 127254
SPIN-код: 8672-4853
References
1. Аksenova V.А., Baryshnikova L.А., Klevno N.I., Kudlay D.А. Screening of children and adolescents for tuberculosis infection in Russia - past, present, future. Tuberculosis and Lung Diseases, 2019, vol. 97, no. 9, pp. 59-67. (In Russ.)
2. Аksenova V.А., Levi D.T., Аleksandrova N.V., Kudlay D.А., Baryshnikova L.А., Klevno N.I. Tuberculosis in children: contemporary methods of prevention and early detection. Doktor.ru, 2017, no. 15 (144), pp. 9-15. (In Russ.)
3. Аksenova V.А., Sterlikov S.А., Belilovsky E.M., Kazykina T.N., Rusakova L.I. Tuberculosis epidemiology in children. Sovremennye Problemy Zdravookhraneniya i Meditsinskoy Statistiki, 2019, no. 1, pp. 8-43. (In Russ.) doi: 10.24411/2312-2935-2019-10002.
4. Kudlay D.А. Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection. Tuberculosis and Lung Diseases, 2020, vol. 98, no. 8, pp. 63-74. (In Russ.) http://doi.org/10.21292/2075-1230-2020-98-863-74.
5. Kudlay D.А., Starshinova А.А., Dovgalyuk I.F. Tuberculous recombinant allergen: 10-year experience of using this test in children and adolescents in the Russian Federation (data of meta analysis). Pediatriya im. G.N. Speranskogo 2020, vol. 99, no. 3, pp. 121-129. (In Russ.)
6. Nechaeva O.B. Tuberculosis among children in Russia. Tuberculosis and Lung Diseases, 2020, no. 11 (98), pp. 12-20. (In Russ.) doi: 10.21292/2075-1230-2020-98-11-12-20.
7. Otraslevye i ekonomicheskie pokazateli protivotuberkuleznoy raboty v 2018-2019 gg. Analiticheskiy obzor osnovnykh pokazateley i statisticheskiye materialy. [Sectorial and economic rates for TB control in 2018-2019. Analysis of main rates and statistic materials]. Moscow, RIO TSNIIOIZ Publ., 2020, 92 p. ISBN: +7 (4012)-94116-030-3.
8. Adejumo O.A., Daniel O.J., Adebayo B.I., Adejumo E.N., Jaiyesimi E.O., Akang G., Awe A. Treatment outcomes of childhood TB in Lagos, Nigeria. J. Trop. Pediatr., 2016, vol. 62, no. 2, pp. 131-138.
9. Definitions and reporting framework for tuberculosis – 2013 revision. WHO/HTM/TB/2013.2. Avaliable at: http://apps.who.int/iris/bitstream/10665/79199/1/9789241505345_eng.pdf (accessed 28 June 2019).
10. Hamid M., Brooks M.B., Madhani F., Ali H., Naseer M.J. Risk factors for unsuccessful tuberculosis treatment outcomes in children. PLoS One, 2019, vol. 14, no. 9, pp. e0222776. doi: 10.1371/journal.pone.0222776.
11. Ohene S.A., Fordah S., Boni P.D. Childhood tuberculosis and treatment outcomes in Accra: a retrospective analysis. BMC Infect. Dis., 2019, vol. 19, pp. 749. doi: 10.1186/s12879-019-4392-6.
12. Sterlikov S., Rusakova L., Ergeshov A., Mikhaylova Y. Demographic characteristics of drug-resistant tuberculosis in the Russian Federation. Eur. Respir. J., 2020, vol. 66, sullp. 64, pp. 473. doi: 10.1183/13993003.congress-2020.473. Available: https://erj.ersjournals.com/content/56/suppl_64/473.
13. Tilahun G., Gebre-Selassie S. Treatment outcomes of childhood tuberculosis in Addis Ababa: a five-year retrospective analysis. BVC Public Health, 2016, vol. 16, pp. 612. doi: 10.1186/s12889-016-3193-8.
14. Tuberculosis surveillance and monitoring in Europe 2020 (2018 data). WHO, 2020, 190 p. doi: 10.2900/0737073; TQ-AO-20-001-EN-C.
Review
For citations:
Аksenova V.A., Rusakova L.I., Sterlikov S.A. Tuberculosis treatment outcomes in children. Tuberculosis and Lung Diseases. 2021;99(10):7-13. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-10-7-13
Views:
1079
Email this article 