Clinical factors associated with unfavorable outcomes in HIV-positive tuberculosis patients
https://doi.org/10.21292/2075-1230-2021-99-10-28-34
Abstract
The objective: to identify clinical factors with the highest sensitivity and specificity associated with an unfavorable outcome in the patient with tuberculosis and HIV infection.
Subjects. 363 patients with TB/HIV co-infection. Group 1 – 59 (16.3%) patients with the unfavorable outcome, Group 2 – 304 (83.7%) patients with a favorable outcome.
Methods: analysis of paired contingency tables by Pearson criterion, quantitative signs by Mann – Whitney test, simple and multiple logistic regression.
Results. The following factors promoting unfavorable outcomes in the patient with TB/HIV co-infection with the highest sensitivity and specificity were identified: hemoglobin level (sensitivity – 78.0%; specificity – 73.7%), gastrointestinal candidiasis (72.9% and 84.5%), loose stool (40.7% and 97.4%), no lymphadenopathy (89.8% and 57.2%), and headache (49.2% and 88.5%). The combination of these clinical manifestations provides sensitivity of 78.0% and specificity of 94.4%.
A formula is proposed for calculating the probability of an unfavorable outcome in the patient TB/HIV co-infection.
About the Authors
V. S. Borovitskiy
Medical Unit of Penal Colony no. 43 by Federal Prosecution Service; Kirov State Medical University
Russian Federation
Russian Federation
Vladislav S. Borovitsky, Candidate of Medical Sciences, Phthisiologist
Zapadny Dr., Kirovo-Chepetsk, Kirovskaya Region, 613040, phone: +7 (3361) 4-60-39, ext. 2-29
M. V. Sinitsyn
Moscow Municipal Scientific Practical Center for Tuberculosis Control of Moscow Health Department
Russian Federation
Russian Federation
Mikhail V. Sinitsyn, Doctor of Medical Sciences, Deputy Director for Research, Reporting and Statistics
10, Stromynka St., Moscow, 107014, phone: +7 (495) 268-00-05
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Review
For citations:
Borovitskiy V.S., Sinitsyn M.V. Clinical factors associated with unfavorable outcomes in HIV-positive tuberculosis patients. Tuberculosis and Lung Diseases. 2021;99(10):28-34. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-10-28-34
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