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Efficacy and safety of short course chemotherapy regimens in older children and adolescents with multiple and extensive drug resistant respiratory tuberculosis

https://doi.org/10.21292/2075-1230-2021-99-10-35-39

Abstract

The objective of the study: to evaluate the efficacy and safety of short course chemotherapy regimens for multiple/extensive drug resistant tuberculosis of the respiratory system (MDR/XDR) in older children and adolescents.

Subjects and Methods. A cohort prospective controlled study (2017 to 2019) included 23 patients from 13 to 17 years old with various clinical forms of respiratory tuberculosis with multiple/extensive drug resistance.

Results. In 22 out of 23 cases, the following chemotherapy regimen was used: 6 months - the intensive phase / 6 months - the continuation phase, in one patient – 3 months of the intensive phase / 9 months of the continuation phase. In 15 out of 23 cases, the chemotherapy regimens in the intensive phase, taking into account the MBT drug sensitivity test, consisted of 5 drugs, in 8 cases – of 4 drugs. During the continuation phase, all patients received 3 drugs. Of the 23 patients, 8 patients used bedaquiline in short course chemotherapy regimens: 2 – 1 course, 6 – 2 courses.

Conclusion. The possibility of reducing the main course of chemotherapy for MDR/XDR TB in children and adolescents to 12 months instead of 18-24 months has been proved.

About the Authors

L. V. Panova
Central Tuberculosis Research Institute
Russian Federation

Ludmila V. Panova, Doctor of Medical Sciences, Leading Researcher of Children and Adolescents Department

2, Yauzskaya Alleya, Moscow, 107564, phone: +7 (499) 785-90-05



E. S. Ovsyankina
Central Tuberculosis Research Institute
Russian Federation

Elena S. Ovsyankina, Doctor of Medical Sciences, Professor, Head of Children and Adolescents Department

2, Yauzskaya Alleya, Moscow, 107564, phone: +7 (499) 785-90-05



E. A. Krushinskaya
Central Tuberculosis Research Institute
Russian Federation

Ekaterina A. Krushinskaya, Junior Researcher of Children and Adolescents Department

2, Yauzskaya Alleya, Moscow, 107564, phone: +7 (499) 785-90-05



A. Yu. Khiteva
Central Tuberculosis Research Institute
Russian Federation

Antonina Yu. Khiteva, Candidate of Medical Sciences, Researcher of Children and Adolescents Department

2, Yauzskaya Alleya, Moscow, 107564, phone: +7 (499) 785-90-05



O. A. Piskunova
Central Tuberculosis Research Institute
Russian Federation

Olga A. Piskunova, Physician of Children and Adolescents Department

2, Yauzskaya Alleya, Moscow, 107564, phone: +7 (499) 785-90-05



References

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Review

For citations:


Panova L.V., Ovsyankina E.S., Krushinskaya E.A., Khiteva A.Yu., Piskunova O.A. Efficacy and safety of short course chemotherapy regimens in older children and adolescents with multiple and extensive drug resistant respiratory tuberculosis. Tuberculosis and Lung Diseases. 2021;99(10):35-39. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-10-35-39

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)