Possibilities of specific immunological tests in patients with TB/HIV coinfection
https://doi.org/10.21292/2075-1230-2021-99-10-46-51
Abstract
The objective of the study: to study the possibilities of skin tests with tuberculosis recombinant allergen (TRA) in the diagnosis of tuberculosis in HIV-positive patients in the region with a high prevalence of tuberculosis.
Subjects and Methods. Medical files of 85 patients were retrospectively analyzed, all the patients suffered from TB/HIV coinfection and underwent the skin test with TRA.
Results. The skin test with TRA was found to be significantly valuable for the diagnosis of tuberculosis in patients with TB/HIV coinfection. The correlation between the intensity of response to the TRA test and CD4+ count was detected (p = 0.011). The lowest values were observed for CD4+ counts below 100 cells/μL. The direct correlation between the intensity of response to TRA and the stage of HIV infection was proved. No effect of the form of tuberculosis, the phase of the tuberculosis disease, or drug sensitivity on the intensity of response to TRA was found. Among tuberculosis patients with bacterial excretion (n = 48), 68.8% of patients responded positively to the TRA test, and in those with no bacterial excretion, the positive reaction was observed in 81.1%.
About the Authors
L. N. Motanova
Pacific State Medical University
Russian Federation
Russian Federation
Lyudmila N. Motanova, Doctor of Medical Sciences, Professor of Therapy and Instrumental Diagnostics Institute
2, Pyatnadtsataya St., Vladivostok, 690000
M. S. Grabovskaya
Naval Clinical Hospital no. 1477
Russian Federation
Russian Federation
Maria S. Grabovskaya, Head of Tuberculosis Department
4, Ivanovskaya St., Vladivostok, 690005
I. V. Folts
Primorsky Regional TB Dispensary
Russian Federation
Russian Federation
Irina V. Folts, Head of Polyclinic Department no. 3
37/ 39, Flotskaya St., Vladivostok, 690013
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Review
For citations:
Motanova L.N., Grabovskaya M.S., Folts I.V. Possibilities of specific immunological tests in patients with TB/HIV coinfection. Tuberculosis and Lung Diseases. 2021;99(10):46-51. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-10-46-51
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