Matrix Metalloproteinases in Pathogenesis of Ventilation Disorders of the Respiratory System in Patients with Chronic Pulmonary Tuberculosis
https://doi.org/10.21292/2075-1230-2022-100-10-22-29
Abstract
The imbalance in matrix metalloproteinase (MMP)/inhibitors system leads to degradation of extracellular matrix of connective tissue and pathological remodeling forming the morphological basis for respiratory dysfunction.
The objective: to study the relationship between parameters of MMP/inhibitors system in blood and parameters of ventilation and gas exchange disorders in patients with chronic pulmonary tuberculosis (PTB).
Subjects and Methods. Patients with the verified diagnosis of tuberculoma (n = 45) and fibrous-cavernous pulmonary tuberculosis (n = 85) were examined. All patients underwent computed tomography of the chest and assessment of respiratory function. Serum concentrations of MMP-1, -3, -8, -9 and their inhibitors TIMP-1 and α2-macroglobulin (MG) were tested by ELISA (R&D Systems, Minneapolis, MN, USA). Statistica 7.0 and an ANCOVA model were used for statistical analysis which considered the diagnosis and smoking status as factors, and the respiratory function parameters were considered as covariates.
Results. In pulmonary tuberculosis patients, the concentrations of MMP-9 and MMP-8 in the blood correlated with extension of lung parenchyma lesions when compared to tuberculomas and fibro-cavernous tuberculosis, MMP-9 and TIMP-1 with changes in lung volumes (R2 = 0.60 and 0.80; p = 0.001), and MMP-8 correlated with functional disorders of gas exchange (R2 = 0.60 and 0.80; p = 0.001). Changes in MMP-1, MMP-3, and α2-MG (R2 = 0.60 and 0.80; p = 0.45) did not correlate with extension of lung parenchymal lesions and decreased lung function.
About the Authors
D. S. Esmedlyaeva
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Dilyara S. Esmedlyaeva, Candidate of Biological Sciences, Senior Researcher
2-4, Ligovsky Ave., St. Petersburg, 191036
Phone: + 7 (812) 297-86-03
N. P. Alekseeva
Pavlov First Saint Petersburg State Medical University; St. Petersburg University
Russian Federation
Russian Federation
Nina P. Alekseeva, Senior Researcher, Department of Pharmacoepidemiology and Biomedical Statistics
6-8, Lva Tolstogo St., St. Petersburg, 197022
L. D. Kiryukhina
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Larisa D. Kiryukhina, Candidate of Medical Sciences, Leading Researcher, Associate Professor, Head of Functional Diagnostics Department
2-4, Ligovsky Ave., St. Petersburg, 191036
Phone: + 7 (812) 297-86-03
M. E. Dyakova
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Marina E. Dyakova, Candidate of Biological Sciences, Senior Researcher
2-4, Ligovsky Ave., St. Petersburg, 191036
Phone: + 7 (812) 297-86-03
References
1. Bogolyubova G.M., Sankovskiy A.A., Scherbak I.G. Ways of inactivation of blood plasma α2-macroglobulin. Laboratornoye Delo, 1988, no. 11, pp. 13-15. (In Russ.)
2. Gavrilov P.V., Baulin I.A., Lukina O.V. Standardized interpretation and control of identified single lung nodule by the Lung Imaging Reporting and Data System (Lung-RADS ™). Meditsinsky Alyans, 2017, no. 3, pp. 17-27. (In Russ.)
3. Zorin N.A., Zorina V.N., Zorina R.M., Levchenko V.G. A2-macroglobulin as a universal regulator. Clin. Lab. Diagnostika, 2004, no. 11, pp. 18-21. (In Russ.)
4. Albaiceta G., Gutierrez-Fernández A., García-Prieto E., Parra X., Astudillo A., Campestre C., Cabrera S., Lopez A., Fueyo A., Taboada F., López-Otin C. Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury. Am. J. Respir. Cell Mol. Biol., 2010, vol. 43, no. 5, pp. 555-563. doi: 10.1165/rcmb.2009-0034Oс.
5. Bassiouni W., Ali M., Schulz R. Multifunctional intracellular matrix metalloproteinases: implications in disease. FEBS J., 2021, vol. 288, no. 24, pp. 7162-7182. doi: 10.1111/febs.15701.
6. Cane J., Mallia-Millanes B., Forrester D., Knox A., Bolton C., Johnson S. Matrix metalloproteinases -8 and -9 in the airways, blood and urine during exacerbations of COPD. COPD, 2016, vol. 13, no. 1, pp. 26-34. doi: 10.3109/15412555.2015.1043522.
7. Chushkin M., Ots O. Impaired pulmonary function after treatment for tuberculosis: the end of the disease? J. Bras. Pneumol., 2017, vol. 43, no. 1, pp. 38-43. doi 10.1590/s1806-37562016000000053.
8. Crotty L. Shin S., Hwang J. Inflammatory diseases of the lung induced by conventional cigarette smoke. Chest, 2015, vol. 148, no. 5, pp. 1307-1322. doi: 10.1378/chest.15-0409.
9. Devereux G., Steele S., Jagelman T., Fielding S., Muirhead R., Brady J., Grierson C., Brooker R., Winter J., Fardon T., McCormick J., Huang J.T., Miller D. An observational study of matrix metalloproteinase (MMP)-9 in cystic fibrosis. J. Cyst. Fibros., 2014, vol. 13, pp. 557-563. doi.org/10.1016/j.jcf.2014.01.010.
10. Esmedljaeva D., Lavrova A., Belik V., Postnikov E. Identification of markers of acute inflammatory process in the pulmonary tuberculosis. ICIIBMS- (4th International Conference on Intelligent Informatics and Biomedical Sciences). 2019, pp. 313-314.
11. Higashimoto Y., Iwata Т., Okada M., Satoh H., Fukuda K., Tohda Y. Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. Respir. Medicine, 2009, vol. 103, no. 8, pp. 1231-1238. doi: 10.1016/j.rmed.2009.01.021.
12. Hrabec E., Strek M., Zieba M., Kwiatkowska S. Circulation level of matrix metalloproteinase-9 is correlated with disease severity in tuberculosis patients. Int. J. Tuberc. Lung Dis., 2002, vol. 6, no. 8, pp. 713-719.
13. Koo H., Hong Y., Lim M., Yim J., Kim W. Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity. Int. J. Chron. Obstruct. Pulmon. Dis., 2016, vol. 11, pp. 1129-1137. doi: 10.2147/COPD.S103281.
14. Miller M., Hankinson J., Brusasco V., Burgos F., Casaburi R., Coates A., Enright P., van der Grinten C., Gustafsson P., Jensen R., Macintyre N., McKay T., Pedersen O., Pellegrino R., Viegi G., Wanger J. Standardisation of spirometry. Eur. Respir. J., 2005, vol. 26, pp. 319-338. doi: 10.1183/09031936.05.00034805.
15. Ostridge K., Williams N., Kim V., Harden S., Bourne S., Coombs N., Elkington P., Estepar R., Washko G., Staples K., Wilkinson T. Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. Respir. Res., 2016, vol. 17, no. 1, pp. 92. doi: 10.1186/s12931-016-0402-z.
16. Pellegrino R., Viegi G., Brusasco V., Crapo R.O., Burgos F., Casaburi R., Coates A., van der Grinten C., Gustafsson P., Hankinson J., Jensen R., Johnson D.C., MacIntyre N., McKay R., Miller M.R., Navajas D., Pedersen O.F., Wanger J. Interpretative strategies for lung function tests. Eur. Respir. J., 2005, vol. 26, no. 5, pp. 948-968. doi: 10.1183/09031936.05.00035205.
17. Pifferi M., Bush A., Caramella D., Maggi F., Peroni D., Boner A. Matrix metalloproteinases and airway remodeling and function in primary ciliary dyskinesia. Respir. Med., 2017, vol. 124, pp. 49-56. doi.org/10.1016/j.rmed.2017.02.001.
18. Sabir N., Hussain T., Mangi M., Zhao D., Zhou X. Matrix metalloproteinases: Expression, regulation and role in the immunopathology of tuberculosis. Cell Prolif., 2019, vol. 52, no. 4, pp. 12649. doi: 10.1111/cpr.12649.
19. Todd J. , Vinisko R., Liu Y.,Neely M., Overton R., Flaherty K., Noth I., Newby L., Lasky J., Olman M., Hesslinger C., Leonard T., Palmer S., Belperio J. Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry. Respir. Res., 2019, vol. 20, no. 1, pp. 227. doi: 10.1186/s12931-019-1190-z.
20. Ugarte-Gil C., Elkington P., Gilman R., Coronel J., Tezera L., Bernabe-Ortiz A, Gotuzzo E., Friedland J., Moore D. Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis. PloS One, 2013, vol. 8, no. 4. doi: e61333.10.1371.
21. Wade J., Mortenson R., Irvin C. Physiologic evaluation of bullous emphysema. Chest, 1991, vol. 100, no. 4, pp. 1151-1154. doi: 10.1378/chest.100.4.1151.
Review
For citations:
Esmedlyaeva D.S., Alekseeva N.P., Kiryukhina L.D., Dyakova M.E. Matrix Metalloproteinases in Pathogenesis of Ventilation Disorders of the Respiratory System in Patients with Chronic Pulmonary Tuberculosis. Tuberculosis and Lung Diseases. 2022;100(10):22-29. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-10-22-29
Views:
354
Email this article 