Factors Associated with Tuberculosis Relapses Development
https://doi.org/10.21292/2075-1230-2022-100-10-30-36
Abstract
The objective: to identify socio-demographic, clinical and laboratory factors associated with tuberculosis recurrence.
Subjects and Methods. Clinical and laboratory data of 208 TB patients treated at the National Scientific Center for Phthisiopulmonology of the Ministry of Health of the Republic of Kazakhstan were analyzed.
IL-2 to the AlaDH was assessed using test platforms Lionex GmbH (Germany) according to the manufacturer's instructions. SPSS 23.0 software was used for statistical processing of obtained data. To assess the significance of differences in groups, the Pearson Chi-Square test was used. To determine the factors associated with of the tuberculosis relapse, а multiple binary logistic regression analysis was carried out.
Results. Multivariate logistic regression analysis confirmed that male gender (OR = 2.086, 95% CI 1.001-4.350, p = 0.050), drug resistance (OR = 4.910, 95% CI 1.923-12.534, p = 0.001), fibrosis cavernous tuberculosis (OR = 6.362, 95% CI 2.178-18.585, p = 0.001) and low level of sensitized T cells that synthesize IL-2 in response to exposure to the AlaDH antigen in IGRA in vitro (OR = 2.155, 95% CI 1.060-4.379, p = 0.034) were significantly associated with tuberculosis recurrence.
About the Authors
A. A. Abilbayeva
Kazakh National Medical University Named after S. D. Asfendiyarov
Russian Federation
Russian Federation
Araylym A. Abilbayeva, Assistant of General Immunology Department
94, Tole Bi St., Almaty, 050000
Phone: +7 705 736-28-32
A. S. Tarabayeva
Kazakh National Medical University Named after S. D. Asfendiyarov
Russian Federation
Russian Federation
Anel S. Tarabayeva, Doctor of Medical Sciences, Professor of General Immunology Department
94, Tole Bi St., Almaty, 050000
Phone: 10.2174-95
I. M. Okhas
Kazakh National Medical University Named after S. D. Asfendiyarov
Russian Federation
Russian Federation
Inkar M. Ohas, Assistant of General Immunology Department
94, Tole Bi St., Almaty, 050000
Phone: +7 777 229-06-64
D. K. Kuashova
Kazakh National Medical University Named after S. D. Asfendiyarov
Russian Federation
Russian Federation
Dinara K. Kuashova, Lecturer of General Immunology Department
94, Tole Bi St., Almaty, 050000
Phone: +7 775 871-60-88
I. M. Khaertynova
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Ilsiyar M. Khaertynova, Professional Education, Doctor of Medical Sciences, Head of Infectious Diseases Department
83, Pobedy Ave., Kazan, 420102
Phone: (843) 267-81-17
E. A. Shuralev
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education; Kazan Federal University; Kazan State Academy of Veterinary Medicine Named after N. E. Bauman
Russian Federation
Russian Federation
Eduard A. Shuralev, Candidate of Veterinary Sciences, Associate Professor of Applied Environment Protection Department
18, Kremlevskaya St., Kazan, 420008
Phone: +7 843 233-73-57
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For citations:
Abilbayeva A.A., Tarabayeva A.S., Okhas I.M., Kuashova D.K., Khaertynova I.M., Shuralev E.A. Factors Associated with Tuberculosis Relapses Development. Tuberculosis and Lung Diseases. 2022;100(10):30-36. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-10-30-36
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