Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray)
https://doi.org/10.21292/2075-1230-2022-100-11-48-55
Abstract
The objective: evidence-based study of the factors influencing tuberculosis mortality in the Kamchatskiy Kray as a territory withlow population density.
Subjects and Methods. A retrospective cohort study of the unfavorable course of tuberculosis in 512 patients with tuberculosis (new cases and relapses) was carried out. A univariate and multivariate analysis of risk factors for a lethal outcome of tuberculosis was performed.
Results. In a univariate analysis, the incidence of death from tuberculosis among increased in older patients (p < 0.0001), among the unemployed, pensioners and disabled (p = 0.02), homeless (p = 0.01), persons who failed to undergo fluorography for 2 years or more (p = 0.004), patients with a positive result of sputum smear test at registration (p = 0.003), and those suffering from alcoholism (p = 0.03), and decreased in patients who were actively detected (p < 0.0001 ). There was no influence on the probability of death from tuberculosis in the registration group by such parameters as new cases/relapses (p = 0.2), male/female (p = 0.09), urban/rural area of residence (p = 0.7), belonging to the indigenous population (p = 0.6), resistance to rifampicin (p = 1), cardiovascular diseases (p = 0.5), and smoking (p = 0.3). In multivariate analysis, an independent factor that reduced the risk of death was the active detection of tuberculosis patients (aOR = 0.2, p = 0.02).
Conclusion. To reduce the risk of death from tuberculosis in an area with low population density (Kamchatskiy Kray), the priority should be given to improvement of active detection of tuberculosis cases; the proportion of tuberculosis patients detected during preventive screening should be used as an parameter of this improvement.
About the Authors
A. V. Gromov
Kamchatka Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Andrey V. Gromov, Head Physician
SPIN-code: 5818-8859
9, Ordzhonikidze St., Petropavlovsk-Kamchatskiy, Kamchatskiy Kray, 683024
Phone: +7 (4152) 23-34-18
S. A. Sterlikov
Russian Research Institute of Health; National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Sergey A. Sterlikov, Doctor of Medical Sciences, Chief Researcher
SPIN-code: 8672-4853
11, Dobrolyubova St., Moscow, 127254
Phone: +7 (495) 507-82-21
Yu. V. Mikhaylova
Russian Research Institute of Health
Russian Federation
Russian Federation
Yulia V. Mikhaylova, Doctor of Medical Sciences, Professor, Chief Researcher, Project Manager
SPIN-code: 2207-0492
11, Dobrolyubova St., Moscow, 127254
Phone: +7 (495) 507-82-21
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Review
For citations:
Gromov A.V., Sterlikov S.A., Mikhaylova Yu.V. Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray). Tuberculosis and Lung Diseases. 2022;100(11):48-55. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-11-48-55
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