Latent Tuberculosis Infection Among Children and Adults in the Regions with High Prevalence of Tuberculosis
https://doi.org/10.58838/2075-1230-2023-101-1-34-40
Abstract
The objective: to assess the prevalence of latent tuberculosis infection (LTBI) among risk groups in the adult and pediatric population in Siberian and Far Eastern Federal Districts.
Subjects and Methods. Federal and sectoral statistical reporting data (Forms No. 33, 8, 30) for 2018-2021 from Siberian and Far Eastern Federal Districts were retrospectively analyzed. Also, additionally collected data on TRA testing in 2021 in the pediatric and adult population registered as Group VIA of Dispensary Follow-up were analyzed.
Results. The existing forms of statistical reporting do not allow performing reliable assessment of LTBI prevalence and effectiveness of preventive measures in both adults and children. In many regions of Siberian and Far Eastern Federal Districts, there is insufficient coverage with LTBI testing. In 2021, the proportion of children aged 0-17 years with LTBI was 1.9% in Siberian Federal District, and 2.2% in Far Eastern Federal District varying from 0.4 to 31.3% in different regions. In 2021, the proportion of LTBI among contacts, both children and adults, made 17.4-19.9%, on average in the Siberian and Far Eastern Federal Districts varying significantly in different regions from 4.8 to 47.6%.
About the Authors
I. G. Felker
Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health
Russian Federation
Russian Federation
Irina G. Felker, Candidate of Medical Sciences, Senior Researcher of Reporting and Statistics Department
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-78-25
I. V. Pavlenok
Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health
Russian Federation
Russian Federation
Irina V. Pavlenok, Phthisiologist, Chief Pediatric TB Expert of Siberian Federal District
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-78-25
N. V. Stavitskaya
Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health
Russian Federation
Russian Federation
Natalia V. Stavitskaya, Doctor of Medical Sciences, Director
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-78-25
D. A. Kudlay
I.M. Sechenov First Moscow State Medical University (Sechenov University); Immunology Research Institute by the Russian Federal Medical Biological Agency
Russian Federation
Russian Federation
Dmitry A. Kudlay, Correspondent Member of RAS, Doctor of Medical Sciences, Professor of Pharmacology Department of Pharmaceutical Science Institute
8, Bd. 2, Trubetskaya St., Moscow, 119991
References
1. Aksenova V.A., Baryshnikova L.A., Klevno N.I., Kudlay D.A. Screening for tuberculosis infection in children and adolescents in Russia - past, present, future. Tuberculosis and Lung Diseases, 2019, vol. 97, no. 9, pp. 59-67. (In Russ.)
2. Aksenova V.A., Klevno N.I., Baryshnikova L.A., Kudlay D.A., Nikolenko N.Yu., Kurilla A.A. Metodicheskiye rekomendatsii Vyavleniye tuberkuleza i taktika dispansernogo nabludeniya za litsami iz grupp riska s ispolzovaniyem rekombinantnogo tuberkuleznogo allergena - Diaskintest®. [Guidelines on detection of tuberculosis and tactics for dispensary follow-up over risk groups with the use of the recombinant tuberculous allergen– Diaskintest®]. Moscow, Pervy MGMU im. I. M. Sechenova Publ., 2011, 12 p.
3. Aksenova V.A., Levi D.T., Aleksandrova N.V., Kudlay D.A., Baryshnikova L.A., Klevno N.I. Tuberculosis in children: contemporary methods of prevention and early detection. Doktor.Ru, 2017, vol. 15, no. 144, pp. 9-15. (In Russ.)
4. Vasilyeva I.A., Testov V.V., Sterlikov S.A. Tuberculosis situation in the years of the COVID-19 pandemic – 2020-2021. Tuberculosis and Lung Diseases, 2022, vol. 100, no. 3, pp. 6-12. (In Russ.)
5. Glebovich O.V., Zaretskiy E.I., Zaretskiy V.F. Tuberkulez: Uchebnik. [Tuberculosis. Handbook]. Leningrad, 1978, 191 p.
6. Pavlenok I.V., Zorina M.M., Pushkareva E.Yu., Felker I.G., Stavitskaya N.V. Organizatsiya profilakticheskikh protivotuberkuleznykh meropriyatiy: uchebnoye posobiye. [Organization of preventive anti-tuberculosis activities: a handbook]. Novosibirsk, FGBU NNIIT Minzdrava Rossii Publ., 2022, 160 p.
7. Pavlenok I.V., Tursunova N.V., Naryshkina S.L., Smolina E.A. Osnovnye pokazateli protivotuberkuleznoy deyatelnosti v Sibirskom i Dalnevostochnom federalnykh okrugakh (statisticheskiye materialy). [Main rates of anti-tuberculosis activities in Siberian and Far Eastern Federal Districts (statistic materials)]. Novosibirsk, 2021, 104 p. (Epub). Available: https://drive.google.com/file/d/1OqfpNVJymTELebaxgrv4vTsN037R8KAs/view. (Accessed 21.10.2022)
8. Slogotskaya L.V., Bogorodskaya E.M., Senchikhina O.Yu., Nikitina G.V., Kudlay D.A. Formation of risk groups among children facing an advanced risk to develop tuberculosis who should undergo various immunological examinations. Rossiyskiy Pediatricheskiy Journal, 2017, vol. 20, no. 4, pp. 207-213. (In Russ.)
9. Mantoux M. La voie intradermique en tuberculinothe´rapie. Presse Med., 1912, vol. 20. pp. 146-148.
Review
For citations:
Felker I.G., Pavlenok I.V., Stavitskaya N.V., Kudlay D.A. Latent Tuberculosis Infection Among Children and Adults in the Regions with High Prevalence of Tuberculosis. Tuberculosis and Lung Diseases. 2023;101(1):34-40. (In Russ.) https://doi.org/10.58838/2075-1230-2023-101-1-34-40
Views:
1403
Email this article 