Diagnosis of Tuberculosis in Children with Chronic Non-Specific Lung Diseases

The objective: to determine the most significant parameters in the diagnosis of tuberculosis in children with chronic non-specific lung diseases in order to form groups facing a high risk of developing tuberculosis.

Subject and Methods: 236 children were enrolled in the study, who were divided into three groups: TB+CNSLD group – 65 children with primary tuberculosis and concomitant chronic non-specific respiratory disease, TB group - 93 children with active respiratory tuberculosis and a group of 78 children and adolescents with chronic non-specific respiratory diseases without tuberculosis but infected with MTB.

Results. Chronic non-specific lung diseases increase the risk of earlier development of tuberculosis in children. For the first time, effectiveness of IGRA tests and TRA tests for detecting tuberculosis in children infected with tuberculous mycobacteria with both allergic and infectious-inflammatory non-specific lung diseases has been proven.

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