A Clinical Case of Generalized Tuberculosis with Lung and Skin Lesions
https://doi.org/10.58838/2075-1230-2025103-1-90-93
Abstract
The article describes a clinical case of generalized tuberculosis with lung and skin lesion in an immunocompetent patient. It was diagnosed based on detection of M. tuberculosis in sputum and wound discharge by microscopy, molecular genetic tests and culture. Genes typical of rifampicin resistance were also found in M. tuberculosis DNA. The following anti-tuberculosis drugs had been used for treatment which was success: Bedaquiline 400 mg, Cycloserine 750 mg, Linezolid 600 mg, Clofazimine 100 mg, and Levofloxacin 1000 mg. In the 9th month of treatment, the patient demonstrated a favorable treatment outcome: conversion was confirmed by sputum and would discharge microscopy. The wounds on the skin of the body and extremities healed.
About the Authors
L. T. Nikolayan
National Pulmonology Center, the Ministry of Health of Armenia
Armenia
Armenia
Lyubov T. Nikolayan - Candidate of Medical Sciences, Associate Professor, Expert of Post-Graduate Education Programs, Senior Clinician
10 Arzniyskoye Highway, Abovyan, Armenia 2200 Phone: +374 (0222) 2-00-11
N. A. Avetisyan
Yerevan State Medical University Named after Mkhitar Heratsi
Armenia
Armenia
Naira A. Avetisyan - Teacher
2 Koryuna St., Yerevan, Armenia, 0025 Phone: +374 (10) 58-25-32
L. M. Egiazaryan
National Pulmonology Center, the Ministry of Health of Armenia
Armenia
Armenia
Lusine M. Egiazaryan - Candidate of Medical Sciences, Deputy Director for Research, Advisor to the Ministry of Health of Armenia on Tuberculosis and Pulmonology
10 Arzniyskoye Highway, Abovyan, Armenia 2200 Phone: +374 (0222) 2-00-11
References
1. Zaslavskij D.V., Egorova Y.S., Chuprov I.N., Olovyanishnikov I.O., Gurkovskaya Y.Y., Sydikov A.A., Chuzhov A.L., Ovchinnikova Y.E., Dovgalyuk I.F., Starshinova A.A. Disseminated cutaneous tuberculosis. Vestnik Dermatologii I Venerologii, 2018, vol. 94, no. 2, pp. 69-77. (In Russ.)
2. Achraf Machan, Tarik Hanafi, Naoufal Hjira, Mohammed Boui. Tuberculous gummas: Epidemiological, clinical, bacteriological, immunological, and therapeutic features. Int. J. Mycobacteriol., 2018, vol. 7, no. 3, pp. 203-211 https://doi.org/10.4103/ijmy.ijmy_83_18
3. Li-Jia Deng, Qian Ye, Si-Yu Luo, Qin-Xiao Wang, Sheng Fang. Case report: clinical and pathological findings of tuberculous gumma: a case report and literature review. Am. J. Trop. Med. Hyg., 2024, vol. 110, no. 4, pp. 805-808. https://doi.org/10.4269/ajtmh.23-0510
4. Mohta S., Kumar A., Singh N., Wig N. A case of tuberculous gumma: there is more to it than meets the eye. BMJ – Case Rep., 2017, no. 19, pp. bcr2017221701. https://doi.org/10.1136/bcr-2017-221701
5. Priyatam Khadka, Soniya Koirala, Januka Thapaliya. Cutaneous tuberculosis: clinicopathologic arrays and diagnostic challenges. Journal List Dermatol. Res. Pract., 2018, no. 9, pp. 7201973.
6. Shaofang Wu, Wu Wang, Huan Chen, Wen Xiong, Xin Song, Xinmin Yu. Perianal ulcerative skin tuberculosis. Journal List Medicine (Baltimore), 2018, vol. 97, no. 2, pp. е10836.
7. Vanessa Ngan, Staff Writer (2003). Updated by Hon A/Prof Amanda Oakley (2015). Derm Net Update (2023). Available: Cutaneous tuberculosis https://dermnetnz.org/topics/cutaneous-tuberculosis Accessed September 10, 2024
Review
For citations:
Nikolayan L.T., Avetisyan N.A., Egiazaryan L.M. A Clinical Case of Generalized Tuberculosis with Lung and Skin Lesions. Tuberculosis and Lung Diseases. 2025;103(1):90-93. (In Russ.) https://doi.org/10.58838/2075-1230-2025103-1-90-93
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