Spectrum of Drug Resistance of Mycobacterium tuberculosis in the Operated Patients Based on Testing of Resected Specimens of Lung Tissue
S. Z. Suleimanov,
M. V. Sinitsyn,
I. V. Golubenkov,
L. E. Parolina, 
O. V. Lovacheva,
I. A. Vasilyeva
O. V. Lovacheva,
I. A. Vasilyeva https://doi.org/10.58838/2075-1230-2025-103-4-32-37
Abstract
The objective: to compare the spectrum of drug resistance of Mycobacterium tuberculosis obtained from respiratory and surgical specimens of pulmonary tuberculosis patients.
Subjects and Methods. A non-randomized, continuous, single-center retrospective study was performed and included 102 patients who underwent surgery at National Medical Research Center of Phthisiopulmonology and Infectious Diseases for drug-resistant pulmonary tuberculosis from 2018 to 2022. Spectrum of drug resistance of Mycobacterium tuberculosis (MTB) isolated from the respiratory and surgical specimens was retrospectively analyzed.
Results. When comparing the type and spectrum of drug resistance (DR) of MTB isolated from respiratory samples and surgical specimens, inconsistent results were observed in 47 (46%) of 102 patients, of which 21/102 (20.6%) were diagnosed with primary drug resistance, of them 14 (13.7%) patients had MDR and 7 (6.8%) patients had pre-XDR. The consistency of DR spectrum was more often observed in fibrous cavernous tuberculosis versus tuberculomas – in 13 (76.4%) of 17 patients and in 31 (37.8%) of 82, respectively, p = 0.024 (TTF); OR = 5.34; 95% CI: 1.49-19.1.
About the Authors
S. Z. Suleimanov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Sarmat Z. Suleimanov, Post-Graduate Student
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
M. V. Sinitsyn
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health;
Pirogov Russian National Research Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Mikhail V. Sinitsyn, Doctor of Medical Sciences, Deputy Head Physician for Surgery, Professor of Phthisiology Department, Pirogov Russian National Research Medical University
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
I. V. Golubenkov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Ilya V. Golubenkov, Anesthesiologist and Emergency Physician, Head of Emergency Care Department
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
L. E. Parolina
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health;
Pirogov Russian National Research Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Lyubov E. Parolina, Doctor of Medical Sciences, Professor, Head of Education Center, Professor of Phthisiology Department, Pirogov Russian National Research Medical University, Russian Ministry of Health
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
O. V. Lovacheva
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Olga V. Lovacheva, Doctor of Medical Sciences, Professor, Chief Researcher of Department of Differential Diagnostics and Treatment of Tuberculosis and Concurrent Infections
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
I. A. Vasilyeva
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health;
Pirogov Russian National Research Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Irina A. Vasilyeva, Doctor of Medical Sciences, Professor, Director, Head of Phthisiology Department, Pirogov Russian National Research Medical University, Russian Ministry of Health
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
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Review
For citations:
Suleimanov S.Z., Sinitsyn M.V., Golubenkov I.V., Parolina L.E., Lovacheva O.V., Vasilyeva I.A. Spectrum of Drug Resistance of Mycobacterium tuberculosis in the Operated Patients Based on Testing of Resected Specimens of Lung Tissue. Tuberculosis and Lung Diseases. 2025;103(4):32-37. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-4-32-37
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