Flavonoids as Promising Drugs for Concomitant Therapy during Long-Term Therapy of Drug-Resistant Tuberculosis
https://doi.org/10.58838/2075-1230-2025-103-4-100-108
Abstract
The review analyzed 56 publications in order to investigate the possibility of using flavonoids as concomitant therapy in the long-term treatment of multidrug-resistant tuberculosis (MDR TB) and to determine the relevance of such studies. Publications were selected from main databases including RSCI, PubMed, and Google Scholar. The use of bioflavonoids in tuberculosis chemotherapy can enhance its effectiveness and prevent toxic effects of anti-tuberculosis drugs. The growing rate of MDR TB among new tuberculosis cases confirms the relevance in this study.
Supporting agencies: The study was carried out as a part of the State Assignment of the Russian Ministry of Health (Reg. No. 1024030100147-3).
About the Authors
G. N. Maslyakova
V.I. Razumovsky Saratov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Galina N. Maslyakova, Doctor of Medical Sciences, Professor, Head of Pathological Anatomy Department
112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03
N. V. Polukonova
V.I. Razumovsky Saratov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Natalya V. Polukonova, Doctor of Biological Sciences, Professor, Professor of Department of General Biology, Pharmacognosy and Botany
112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03
T. I. Morozova
V.I. Razumovsky Saratov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Tatyana I. Morozova, Doctor of Medical Sciences, Professor, Head of Phthisiology Department
112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03
D. A. Kudlay
I.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of Health;
Lomonosov Moscow State University;
Immunology Research Institute by the Russian Federal Medical Biological Agency
Russian Federation
Russian Federation
Dmitry A. Kudlay, Correspondent Member of RAS, Doctor of Medical Sciences, Professor of Pharmacology Department of Pharmacy Institute, Leading Researcher of Laboratory of Personalized Medicine and Molecular Immunology no. 71, Immunology Research Institute by the Russian Federal Medical Biological Agency, Professor of Department of Pharmacognosy and Industrial Pharmacy, Faculty of Fundamental Medicine, Lomonosov
8 Bd. 2, Trubetskaya St., Moscow, 119991 Phone: +7 (499) 248-05-53
A. B. Bucharskaya
V.I. Razumovsky Saratov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Alla B. Bucharskaya, Doctor of Biological Sciences, Head of the Center for Collective Use of Experimental Oncology
112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03
A. V. Polukonova
V.I. Razumovsky Saratov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Anna V. Polukonova, Junior Researcher of Cellular Technologies Laboratory, Center for Collective Use of Experimental Oncology
112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03
N. A. Navolokin
V.I. Razumovsky Saratov State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Nikita A. Navolokin, Candidate of Medical Sciences, Associate Professor of Pathologic Anatomy Department
112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03
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Review
For citations:
Maslyakova G.N., Polukonova N.V., Morozova T.I., Kudlay D.A., Bucharskaya A.B., Polukonova A.V., Navolokin N.A. Flavonoids as Promising Drugs for Concomitant Therapy during Long-Term Therapy of Drug-Resistant Tuberculosis. Tuberculosis and Lung Diseases. 2025;103(4):100-108. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-4-100-108
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