Analysis of Predictors of Unfavorable Outcomes of Tuberculosis Treatment in Indigenous Population of the North
https://doi.org/10.58838/2075-1230-2025-103-6-41-47
Abstract
The objective: to study factors influencing treatment outcomes in new tuberculosis patients from indigenous populations of the North (IPN) living in the Yamalo-Nenets Autonomous Area (YNAA).
Subjects and Methods. A retrospective cohort study of treatment outcomes of new patients registered for treatment with drug-susceptible tuberculosis regimens in the Yamalo-Nenets Autonomous Area in 2010-2022 was conducted. A factor analysis of predictors of unfavorable chemotherapy outcomes in patients from indigenous population was performed.
Results. Among patients from indigenous population, there is a lower proportion of successful treatment (58.79%) than among non-native permanent residents (68.45%; p = 0.001) due to high level of consequent drug resistance detection and a higher proportion of patients transferred for treatment with relevant chemotherapy regimens (p < 0.0001), as well as a higher proportion of chemotherapy failures (p = 0.001), in some patients it was associated with alcohol dependence syndrome (aOR = 2.80; p = 0.045), and late detection of tuberculosis (p = 0.01). To reduce the proportion of treatment failures among indigenous populations, it is advisable to consider their annual fluorographic examination.
About the Authors
D. V. Kochetkov
Yamalo-Nenets Regional TB Dispensary
Russian Federation
Russian Federation
Dmitry V. Kochetkov - Supervising Physician
6 Michurina St., Salekhard, Yamalo-Nenetsk Autonomous Area, 629002
Phone: +7 (34922) 3-20-37
Yu. V. Mikhaylova
Russian Research Institute of Health, Russian Ministry of Health
Russian Federation
Russian Federation
Yulia V. Mikhaylova - Doctor of Medical Sciences, Professor, Head Researcher – Project Manager, Honored Researcher of Russia
11 Dobrolyubova St., Moscow, 127254
Phone: +7(495) 618-31-83
V. G. Kudrina
Russian Medical Academy of On-going Professional
Education, Russian Ministry of Health
Russian Federation
Russian Federation
Valentina G. Kudrina - Doctor of Medical Sciences, Professor, Head of Department of Medical Statistics
and Digital Health Care, Honored Doctor of Russia
2/1 Build. 1, Barrikadnaya St., Moscow, 125993
Phone: +7 (495) 680-05-99
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Review
For citations:
Kochetkov D.V., Mikhaylova Yu.V., Kudrina V.G. Analysis of Predictors of Unfavorable Outcomes of Tuberculosis Treatment in Indigenous Population of the North. Tuberculosis and Lung Diseases. 2025;103(6):41-47. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-6-41-47
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