Potential of Pharmacogenetic Testing in Tuberculosis Treatment
https://doi.org/10.58838/2075-1230-2025-103-6-104-116
Abstract
Pharmacogenetic testing is the most promising tool in personalized medicine aimed at enhancing effectiveness and safety of treatment, especially in complicated cases with comorbidities. The review analyzes 122 publications devoted to theoretical and applied aspects of pharmacogenetic testing in the treatment of tuberculosis patients. It considers the role of genetic polymorphisms in the response to treatment, and presents data on proteins involved in pharmacokinetics and pharmacodynamics of main anti-tuberculosis drugs and the genes encoding these proteins. The review analyzes the list of the most significant markers associated with the risk of adverse reactions during treatment of drug-sensitive and drug-resistant tuberculosis, and it characterizes prospects for their use in clinical practice. The list of references contains 56 key publications cited in the text.
About the Authors
D. A. Ivanova
Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health; Russian Medical Academy of On-going Professional Education, Russian Ministry of Health
Russian Federation
Russian Federation
Diana A. Ivanova - Doctor of Medical Sciences, Academic Secretary, Phthisiologist, General Practitioner of City Clinical Diagnostic Center, Professor of Phthisiology Department
10 Build. 1, Stromynka St., Moscow 107014
Phone: +7 (499) 269-14-10
N. Yu. Nikolenko
Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health
Russian Federation
Russian Federation
Nikolay Yu. Nikolenko - Candidate of Pharmacological Sciences, Researcher of Research Clinical Department
10 Build. 1, Stromynka St., Moscow 107014
Phone: +7 (499) 269-14-10
K. Yu. Galkina
Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health
Russian Federation
Russian Federation
Kseniya Yu. Galkina - Candidate of Biological Sciences, Leading Researcher of Department of Laboratory Diagnostics of Tuberculosis and Pathomorphology
10 Build. 1, Stromynka St., Moscow 107014
Phone: +7 (499) 269-14-10
E. I. Yurovskaya
Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health
Russian Federation
Russian Federation
Ekaterina I. Yurovskaya - Phthisiologist of Pulmonary Tuberculosis Department no. 6 of Clinic no. 2
10 Build. 1, Stromynka St., Moscow 107014
Phone: +7 (499) 269-14-10
Yu. Yu. Mitrofanova
Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health
Russian Federation
Russian Federation
Yulia Yu. Mitrofanova - Researcher of Research Clinical Department
10 Build. 1, Stromynka St., Moscow 107014
Phone: +7 (499) 269-14-10
D. A. Kudlay
I.M. Sechenov First Moscow State Medical University
(Sechenov University), Russian Ministry of Health; Lomonosov Moscow State University; Immunology Research Institute by the Russian Federal Medical Biological Agency
Russian Federation
Russian Federation
Dmitry A. Kudlay - Correspondent Member of RAS, Doctor of Medical Sciences, Professor of Pharmacology Department of Pharmacy Institute, Leading Researcher of Laboratory of Personalized Medicine and Molecular Immunology no. 71, Immunology Research Institute by the Russian Federal Medical Biological Agency, Professor of Department of Pharmacognosy and Industrial Pharmacy, Fundamental Medicine Faculty, Lomonosov Moscow State University
8 Bd. 2, Trubetskaya St., Moscow, 119991
Phone: +7 (499) 248-05-53
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For citations:
Ivanova D.A., Nikolenko N.Yu., Galkina K.Yu., Yurovskaya E.I., Mitrofanova Yu.Yu., Kudlay D.A. Potential of Pharmacogenetic Testing in Tuberculosis Treatment. Tuberculosis and Lung Diseases. 2025;103(6):104-116. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-6-104-116
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