Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): a Difficult Journey to Diagnosis
Yu. I. Galikhanova,
A. E. Shklyaev,
O. V. Muravtseva,
O. I. Starodubtseva,
A. S. Malygina,
A. S. Pantyukhina https://doi.org/10.58838/2075-1230-2026-104-1-72-78
Abstract
The article describes a rare autoimmune disease – eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) and presents a clinical case . The diagnosis was determined according to the established diagnostic criteria (bronchial asthma, blood eosinophilia - 61.2%, sciatic nerve neuropathy, pulmonary infiltrates, catarrhal polysinusitis, extravascular eosinophilia – eosinophils in sputum and bronchoalveolar lavaged) only 5 months after the onset of the disease. Prior to this, the patient had been hospitalized several times with suspected COVID-19.
About the Authors
Yu. I. Galikhanova
Izhevsk State Medical Academy, Russian Ministry of Health; First Republican Clinical Hospital, Ministry of Health of Udmurtiya Republic
Russian Federation
Russian Federation
Yulia I. Galikhanova, Post-Graduate Student of Faculty Therapy Department with the Training Course in Endocrinology and Hematology, Pulmonologist
57 Votkinskoye Highway, Izhevsk, Udmurtiya Republic,
426039;
Phone: +7 (3412) 42-54-88
A. E. Shklyaev
Izhevsk State Medical Academy, Russian Ministry of Health
Russian Federation
Russian Federation
Aleksey E. Shklyaev, Doctor of Medical Sciences, Rector,
Professor of Faculty Therapy Department with the Training Course in Endocrinology and Hematology
57 Votkinskoye Highway, Izhevsk, Udmurtiya Republic,
426039;
Phone: +7 (3412) 42-54-88
O. V. Muravtseva
First Republican Clinical Hospital, Ministry of Health of Udmurtiya Republic
Russian Federation
Russian Federation
Olga V. Muravtseva, Candidate of Medical Sciences, Deputy Head Physician for Medical Activities, Chief Expert General Practitioner of Ministry of Health of Udmurtiya Republic
57 Votkinskoye Highway, Izhevsk, Udmurtiya Republic,
426039;
Phone: +7 (3412) 46-32-70
O. I. Starodubtseva
First Republican Clinical Hospital, Ministry of Health of Udmurtiya Republic
Russian Federation
Russian Federation
Oksana I. Starodubtseva, Candidate of Medical Sciences, Head of Pulmonology Department, Chief Expert Pulmonologist of Ministry of Health of Udmurtiya Republic
57 Votkinskoye Highway, Izhevsk, Udmurtiya Republic,
426039;
Phone: +7 (3412) 46-32-70
A. S. Malygina
First Republican Clinical Hospital, Ministry of Health of Udmurtiya Republic
Russian Federation
Russian Federation
Alina S. Malygina, Pulmonologist
57 Votkinskoye Highway, Izhevsk, Udmurtiya Republic,
426039;
Phone: +7 (3412) 46-32-70
A. S. Pantyukhina
Izhevsk State Medical Academy, Russian Ministry of Health
Russian Federation
Russian Federation
Angelina S. Pantyukhina, Candidate of Medical Sciences,
Assistant of Faculty Therapy Department with the Training Course in Endocrinology and Hematology
57 Votkinskoye Highway, Izhevsk, Udmurtiya Republic,
426039;
Phone: +7 (3412) 42-54-88
References
1. Adasheva T.V., Nesterenko O.I., Zadionchenko V.S., Kharkova M.S., Samorukova E.I. Clinical case Churg-Strauss syndrome: difficulties in the diagnosis, therapeutic tactics. The Russian Archives of Internal Medicine, 2016, vol. 5, no. 31, pp. 63-69. (In Russ.) http://doi.org/10.20514/2226-6704-2016-6-5-63-69
2. Brodskaya O.N. Eosinophilic granulomatosis with polyangiitis in the practice of a pulmonologist. Astma i Allergiya, 2018, no. 2, pp. 3-7. (In Russ.)
3. Voytsehovskiy V.V., Pogrebnaya M.V., Goborov N.D., Fomina O.P., Goryacheva S.A. Peculiarities of diagnosis and treatment of Churg-Strauss syndrome. Bulletin Physiology and Pathology of Respiration, 2017, no. 64, pp. 79-87. (In Russ.)
4. Zakharova E.V. ANCA-associated and cryoglobulinemic vasculitis: diagnostics and treatment. Nephrology and Dialysis, 2005, vol. 7, no. 1, pp. 6-25. (In Russ.)
5. Zhanuzakov M.A., Zhakypova Zh.O., Seledtsov V.P., Mukatova A.M., Bopaeva M.K., Musimkhan M.K. Difficulties in diagnosing eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Vestnik Almatinskogo Gosudarstvennogo Instituta Usovershenstvovaniya Vrachey, 2014, no. 3, pp. 77-81. (In Russ.)
6. Moiseev S.V., Novikov P.I., Zagvozdkina E.S. Practical guidelines for diagnosis and treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Clin. Pharmacol. Ther., 2016, vol. 25, no. 3, pp. 73-78. (In Russ.)
7. Norkina A.S., Zotova L.A., Nikulenkova N.E. Clinical case of late diagnostics of Churg-Strauss disease. International Research Journal, 2019, vol. 3, no. 81, pp. 65-67. (In Russ.) http://doi.org/10.23670/IRJ.2019.81.3.010
8. Watts R.A., Mahr A., Mohammad A.J., Gatenby P., Basu N., Flores-Suârez L.F. Classification, epidemiology and clinical subgrouping of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Nephrology, Dialysis, Transplantation, 2015, vol. 30, no. 1, pp. 14-22. https://doi.org/10.1093/ndt/gfv022
9. Watts R.A., Lane S.E., Scott D.G., Koldingsnes W., Nossent H., Gonzalez-Gay M.A., Garcia-Porrua C., Ben-tham G.A. Epidemiology of vasculitis in Europe. Annals of Rheumatic Diseases, 2001, vol. 60, no. 12, pp. 1156-1157. https://doi.org/10.1136/ard.60.12.1156a
Review
For citations:
Galikhanova Yu.I., Shklyaev A.E., Muravtseva O.V., Starodubtseva O.I., Malygina A.S., Pantyukhina A.S. Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): a Difficult Journey to Diagnosis. Tuberculosis and Lung Diseases. 2026;104(1):72-78. (In Russ.) https://doi.org/10.58838/2075-1230-2026-104-1-72-78
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