Cytokine Status and Types of Immune Response in Patients with Chronic Obstructive Pulmonary Disease
https://doi.org/10.58838/2075-1230-2026-104-2-68-75
Abstract
The objective: to evaluate cytokine status and types of immune response in patients with chronic obstructive pulmonary disease.
Subjects and Methods. A total of 172 COPD patients with varying degrees of bronchial obstruction (II–IV according to GOLD) in the exacerbation phase were examined. The levels of proinflammatory (IL-1, IL-6, IL-17, IL-21, TNF-α, IFN-γ) and anti-inflammatory (IL-4, IL-10, TGF-β1) cytokines were tested. Correlation and cluster analyses were performed to identify types of immune response (Th1, Th1/Th17, Th17).
Results. It was found out that as bronchial obstruction increased in COPD patients, the production of IL-6, TGF-β1 and IL-10 increased. At different stages, there were different types of immune response; among 172 patients, Th1 was found in 22.1%, Th1/Th17 in 33.7%, and Th17 in 44.2%. Th17 was more common in extremely severe bronchial obstruction (GOLD IV) and was associated with pronounced hyperproduction of IL-17, IL-21, IL-6, and TGF-β1.
Conclusion. The cytokine profile in COPD reflects the formation of Th1, Th1/Th17 and Th17 types of immune response, which determines characteristics of the course of the disease and may possibly serve as a prognostic marker.
About the Authors
G. T. Tashmetova
Center for Professional Development of Medical Personnel
Uzbekistan
Uzbekistan
Gulchekhra T. Tashmetova - Assistant of Pulmonology Department with Training Course in Clinical Allergology
51 Parkentskaya St., Tashkent, 100007
Phone: + 998 712681744
I. V. Liverko
Republican Special Research Medical Center of Phthisiatry and Pulmonology
Uzbekistan
Uzbekistan
Irina V. Liverko - Deputy Director for Research and Innovations
1 Mazhlisiy St., Tashkent, 100086
Phone: +998712780470
Kh. M. Tashmetov
Center for Professional Development of Medical Personnel
Uzbekistan
Uzbekistan
Khurshidbek M. Tashmetov - Associate Professor of Pulmonology Department with Training Course in Clinical Allergology
51 Parkentskaya St., Tashkent, 100007
Phone: + 998 712681744
References
1. Avdeev S.N., Leschenko I.V., Aisanov Z.R., Arkhipov V.V., Belevsky A.S., Ovcharenko S.I. New clinical guidelines for COPD – a paradigm shift. Terapevticheskiy Arkhiv, 2024, vol. 96, no. 3, pp. 292-297. (In Russ.)
2. Berikkhanov Z.G., Nikolaev A.M., Seregina V.Yu. Treatment of chronic obstructive pulmonary disease and emphysema. Pirogov Russian Journal of Surgery, 2023, no. 9, pp. 79-85. (In Russ.)
3. Chen Z., Li W., Tang Y. et al. The neutrophil-lymphocyte ratio predicts all-cause and cardiovascular mortality among United States adults with COPD: results from NHANES 1999–2018. Sec. Pulmonary Medicine, 2024, vol. 11, pp. 1443749 https://doi.org/10.3389/fmed.2024.1443749
4. Fang L., Zhu J., Fu D. et al. Predictive value of neutrophil-lymphocyte ratio for all-cause mortality in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. BMC Pulm Med., 2025, no. 25, pp. 206. https://doi.org/10.1186/s12890-025-03677-y
5. Kraik K., Tota M., Laska J. et al. The role of transforming growth factor-β (TGF-β) in asthma and chronic obstructive pulmonary disease (COPD). Cells, 2024, vol. 13, no. 15, pp. 1271. https://doi.org/10.3390/cells13151271
6. Xu J., Zeng Q., Li S., Su Q., Fan H. Inflammation mechanism and research progress of COPD. Frontiers in Immunology, 2024, no. 15, pp. 1404615. https://doi.org/10.3389/fimmu.2024.1404615
7. Song Y.D., Bai X.M., Ma J. The association of systemic immune-inflammation index with lung function, risk of COPD and COPD severity: A population-based study. PLoS One, 2024, vol. 19, no. 6, pp. e0303286. https://doi.org/10.1371/journal.pone.0303286
Review
For citations:
Tashmetova G.T., Liverko I.V., Tashmetov Kh.M. Cytokine Status and Types of Immune Response in Patients with Chronic Obstructive Pulmonary Disease. Tuberculosis and Lung Diseases. 2026;104(2):68–75. (In Russ.) https://doi.org/10.58838/2075-1230-2026-104-2-68-75
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