Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles
https://doi.org/10.21292/2075-1230-2015-0-4-54-57
Abstract
Mutagenous and mitosis modifying impact of silver nanoparticles has been studied on outbred mice. Nanoparticles were of round shape with dimensions of 5-50 nm, size of generated organic shell of 2-5 nm, the quantity in 1 mcm3 makes 120-270. Metaphasic analysis of mice bone marrow cells was used as a testing technique. The frequency of chromosome aberrations and mitotic index of preparations were accounted. During single intraperitoneal administration of the agent in the dose of 250 mcg/kg the silver nanoparticles demonstrated mitosis stimulating activity. No mutagenous effect of silver nanoparticles by daily administration for 4 days of 25 mcg/kg and single administration in the dose of 250 mcg/kg has been registered, but there is statistically insignificant tendency of aberrant metaphases increase. Consequently silver nanoparticles in the investigated doses demonstrated no mutagenous activity and can be considered safe for mammalian cells.
About the Authors
B. S. Kirbik
Toxicology Laboratory of Yarsintez Research Institute, Yaroslavl State Medical Academy
Russian Federation
Yaroslavl
Russian Federation
Yaroslavl
S. V. Tikhomirova
Toxicology Laboratory of Yarsintez Research Institute, Yaroslavl State Medical Academy
Russian Federation
Yaroslavl
Russian Federation
Yaroslavl
I. A. Bitkin
Toxicology Laboratory of Yarsintez Research Institute, Yaroslavl State Medical Academy
Russian Federation
Yaroslavl
Russian Federation
Yaroslavl
D. S. Pesnya
P.G. Demidov Yaroslavl State University
Russian Federation
Yaroslavl
Russian Federation
Yaroslavl
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Review
For citations:
Kirbik B.S., Tikhomirova S.V., Bitkin I.A., Pesnya D.S. Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles. Tuberculosis and Lung Diseases. 2015;(4):54-57. (In Russ.) https://doi.org/10.21292/2075-1230-2015-0-4-54-57
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